ZCCHC14 and NFIC

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ZCCHC14	NFIC
Gene Name		zinc finger, CCHC domain containing 14	nuclear factor I/C (CCAAT-binding transcription factor)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component		Nucleus Nucleoplasm Nucleolus
	Molecular Function	Nucleic Acid Binding Zinc Ion Binding Phosphatidylinositol Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity
	Biological Process		Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Replication Transcription From RNA Polymerase II Promoter Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways			RNA Polymerase III Transcription RNA Polymerase III Transcription Termination RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase III Abortive And Retractive Initiation
Drugs
Diseases
GWAS		Major depressive disorder ( 22472876)	Height ( 20881960)
Protein-Protein Interactions		2 interactors: NFIC SMAD3	10 interactors: CREBBP GLRX LLPH NFIB RFX1 TKTL2 TLX1 TPD52L3 ZCCHC14 ZKSCAN7
Entrez ID		23174	4782
HPRD ID		18316	09009
Ensembl ID		ENSG00000140948	ENSG00000141905
Uniprot IDs		Q8WYQ9	B7Z4T6 P08651
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transforming Growth Factor Beta3 Production Evasion Or Tolerance Of Host Defenses By Virus Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly Regulation Of Extracellular Matrix Assembly Primary MiRNA Processing Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway SMAD Protein Complex Assembly Negative Regulation Of Osteoblast Proliferation Transdifferentiation Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of Catenin Import Into Nucleus Positive Regulation Of Alkaline Phosphatase Activity Paraxial Mesoderm Morphogenesis Negative Regulation Of Transcription From RNA Polymerase II Promoter Nodal Signaling Pathway Transcription From RNA Polymerase II Promoter Positive Regulation Of Transforming Growth Factor Beta Production Regulation Of Osteoblast Proliferation Embryonic Foregut Morphogenesis Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Adherens Junction Organization Production Of MiRNAs Involved In Gene Silencing By MiRNA Foregut Morphogenesis Organ Morphogenesis Modulation By Virus Of Host Morphology Or Physiology Paraxial Mesoderm Development Regulation Of Catenin Import Into Nucleus Positive Regulation Of Transcription From RNA Polymerase II Promoter Thyroid Gland Development Osteoblast Development Positive Regulation Of Interleukin-1 Beta Production Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Chondrocyte Differentiation Pericardium Development Positive Regulation Of Phosphatase Activity Positive Regulation Of Positive Chemotaxis Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Interleukin-1 Production Signal Transduction Involved In Regulation Of Gene Expression Activin Receptor Signaling Pathway Lens Fiber Cell Differentiation Positive Regulation Of Epithelial To Mesenchymal Transition Gene Silencing By MiRNA Positive Regulation Of Bone Mineralization Cellular Response To DsRNA Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process	Negative Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Protein Deglutathionylation Lung Ciliated Cell Differentiation Principal Sensory Nucleus Of Trigeminal Nerve Development Negative Regulation Of Mesenchymal Cell Proliferation Involved In Lung Development N-terminal Peptidyl-lysine Acetylation Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Germ-line Stem Cell Maintenance Negative Regulation Of Mesenchymal Cell Proliferation Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Type II Pneumocyte Differentiation Clara Cell Differentiation Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Anterior Commissure Morphogenesis RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process N-terminal Protein Amino Acid Acetylation Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Nucleobase-containing Compound Metabolic Process Lung Secretory Cell Differentiation Commissural Neuron Axon Guidance Positive Regulation Of Sodium Ion Transmembrane Transport Nucleobase-containing Small Molecule Interconversion Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Type I Pneumocyte Differentiation Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Gene Expression N-terminal Protein Amino Acid Modification RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Cellular Response To Heat Nitrogen Compound Metabolic Process Negative Regulation Of Stem Cell Proliferation Gene Expression Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Sodium Ion Transport Central Nervous System Projection Neuron Axonogenesis Cellular Macromolecule Biosynthetic Process
Tagcloud ?			advance avian bcl2 bcl2l1 ccaat cebpb construction coordinated cytoscape datasets differentially downloaded encyclopedia enrichment genomes gse14359 homolog il6 interpret kyoto omnibus ontology osteosarcoma pivotal rara rel rela reticuloendotheliosis tp53
Tagcloud (Difference) ?			advance avian bcl2 bcl2l1 ccaat cebpb construction coordinated cytoscape datasets differentially downloaded encyclopedia enrichment genomes gse14359 homolog il6 interpret kyoto omnibus ontology osteosarcoma pivotal rara rel rela reticuloendotheliosis tp53
Tagcloud (Intersection) ?