SMC5 and CIP2A

Number of citations of the paper that reports this interaction (PubMedID 25833693)
0

Data Source:
BioGRID (two hybrid)

		SMC5	CIP2A
Description		structural maintenance of chromosomes 5	cellular inhibitor of PP2A
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromosome, Telomeric Region Sex Chromosome Nucleus Nucleoplasm Chromosome Cytoplasm PML Body Nuclear Speck Cell Junction Smc5-Smc6 Complex Interchromatin Granule Site Of Double-strand Break	Chromosome Cytoplasm Centrosome Cytosol Plasma Membrane Ciliary Basal Body
	Molecular Function	Nucleotide Binding DNA Secondary Structure Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity	Protein Phosphatase Inhibitor Activity Protein Binding Protein Homodimerization Activity Cadherin Binding
	Biological Process	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Damage Response Chromosome Segregation Protein Sumoylation Stem Cell Population Maintenance Chromosome Condensation Regulation Of Telomere Maintenance Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Mitotic Cell Cycle Phase Transition Host-mediated Suppression Of Viral Genome Replication Chromosome Organization Cell Division Positive Regulation Of Chromosome Segregation Protein Localization To Chromosome, Centromeric Region Cellular Senescence Chromatin Looping	DNA Damage Response Chromosome Organization Broken Chromosome Clustering
Pathways		SUMOylation of DNA damage response and repair proteins
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 27089180)
Interacting Genes		6 interacting genes: CIP2A DISC1 NSMCE2 SMN1 TK1 VHL	22 interacting genes: CDK1 CENPC CEP152 CEP192 CSPP1 GOLGA4 LAMB2 MYC NDC80 NEK2 PIK3R1 PPP2R5C PSMA1 PSMA3 RBM5 RNF2 SMC5 STUB1 SYNCRIP TOPBP1 UBR5 WWC3
Entrez ID		23137	57650
HPRD ID		10241	11151
Ensembl ID		ENSG00000198887	ENSG00000163507
Uniprot IDs		Q8IY18	Q8TCG1
PDB IDs			5UFL
Enriched GO Terms of Interacting Partners?			Nucleoplasm Chromosome Organization Centrosome Chromosome Chromosome, Centromeric Region Centrosome Duplication Procentriole DNA Damage Response Cytosol Positive Regulation Of Chromosome Organization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Chromosome Organization Positive Regulation Of Protein Import Into Nucleus Cytoplasm Microtubule Cytoskeleton Organization Involved In Mitosis Procentriole Replication Complex Chromosome Segregation Mitotic Cell Cycle Membraneless Organelle Assembly Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Process Proteasome Core Complex, Alpha-subunit Complex Cell Cycle Phase Transition Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Nuclear Body Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Catabolic Process Microtubule Organizing Center Organization Ubiquitin-ubiquitin Ligase Activity Kinetochore Organization Positive Regulation Of Intracellular Protein Transport Proteolysis Involved In Protein Catabolic Process Mitotic Spindle Organization Spindle Assembly Cell Division Positive Regulation Of Protein Localization To Nucleus Attachment Of Mitotic Spindle Microtubules To Kinetochore Proteasome Core Complex DNA Metabolic Process Protein Localization To Chromosome Intracellular Signal Transduction Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Cell Cycle Process Peptidyl-threonine Phosphorylation Macromolecule Metabolic Process Regulation Of Cell Cycle PML Body
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