COLGALT2 and HPCAL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		COLGALT2	HPCAL1
Description		collagen beta(1-O)galactosyltransferase 2	hippocalcin like 1
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen	Membrane
	Molecular Function	Protein Binding Transferase Activity Glycosyltransferase Activity Procollagen Galactosyltransferase Activity	Calcium Ion Binding Protein Binding Metal Ion Binding
	Biological Process	Collagen Fibril Organization	Regulation Of Signal Transduction
Pathways		Collagen biosynthesis and modifying enzymes
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Height ( 28552196 31562340) Hip circumference adjusted for BMI ( 34021172) Waist circumference adjusted for body mass index ( 34021172)	Cerebral amyloid angiopathy x sex interaction in Alzheimer’s disease ( 34020725) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Femur bone mineral density x serum urate levels interaction ( 34046847) Kidney function decline traits ( 25493955) Lung function (FEV1/FVC) ( 30061609) Platelet distribution width ( 32888494)
Interacting Genes		3 interacting genes: HPCAL1 UBQLN1 UBQLN2	39 interacting genes: AMOT ATXN1 C19orf44 C1QTNF2 CA3 CEBPA COLGALT2 CREM DTX2 EFEMP2 EPHB3 FZD7 GATA5 HMG20A IKBKG KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP17-1 KRTAP4-2 KRTAP5-9 LITAF MDFI MICOS10-NBL1 MYDGF NBL1 NBPF19 NOTCH2NLA PLAAT2 SERPINI2 SLC34A1 TPSG1 VWC2 ZNF655
Entrez ID		23127	3241
HPRD ID		13583	02564
Ensembl ID		ENSG00000198756	ENSG00000115756
Uniprot IDs		A0A3B3IT37 B3KT92 B4DF84 Q8IYK4	O75544 P37235 Q6FGY1
PDB IDs			5T7C
Enriched GO Terms of Interacting Partners?		Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Interleukin-4-dependent Isotype Switching To IgE Isotypes Positive Regulation Of CD4-positive, Alpha-beta T Cell Costimulation T-helper 2 Cell Activation Response To Nitrogen Dioxide Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Organization Autophagosome Assembly ERAD Pathway Negative Regulation Of Store-operated Calcium Channel Activity Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Memory T Cell Activation Positive Regulation Of T Cell Costimulation Negative Regulation Of G Protein-coupled Receptor Internalization Vacuole Organization Defense Response To Nematode Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Isotype Switching To IgE Isotypes Positive Regulation Of Proteolysis Negative Regulation Of Clathrin-dependent Endocytosis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Macroautophagy Response To Endoplasmic Reticulum Stress Negative Regulation Of Regulatory T Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Tumor Necrosis Factor Receptor Superfamily Binding Autophagy Positive Regulation Of Memory T Cell Differentiation Regulation Of Memory T Cell Differentiation Negative Regulation Of T-helper 1 Type Immune Response Regulation Of T-helper 1 Cell Differentiation Regulation Of Protein Catabolic Process Regulation Of Proteolysis Regulation Of Autophagy Regulation Of Toll-like Receptor 3 Signaling Pathway Aggrephagy Positive Regulation Of Interleukin-13 Production Negative Regulation Of Transport Negative Regulation Of Receptor Internalization Negative Regulation Of Interleukin-17 Production Positive Regulation Of Type 2 Immune Response Regulation Of Clathrin-dependent Endocytosis Cellular Response To Prostaglandin E Stimulus	Intermediate Filament Keratin Filament Identical Protein Binding Sequestering Of BMP In Extracellular Matrix Sequestering Of BMP From Receptor Via BMP Binding Determination Of Dorsal Identity Morphogen Activity Negative Regulation Of Monocyte Chemotaxis Sequestering Of Extracellular Ligand From Receptor Extracellular Negative Regulation Of Signal Transduction Maintenance Of Protein Location Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Developmental Process
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