PPRC1 and CLIC6

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		PPRC1	CLIC6
Description		PPARG related coactivator 1	chloride intracellular channel 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Cytoplasm Plasma Membrane Membrane Monoatomic Ion Channel Complex Chloride Channel Complex Extracellular Exosome
	Molecular Function	Nucleic Acid Binding Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding	Chloride Channel Activity Oxidoreductase Activity D2 Dopamine Receptor Binding D3 Dopamine Receptor Binding D4 Dopamine Receptor Binding
	Biological Process	Positive Regulation Of Transcription By RNA Polymerase II Energy Homeostasis	Monoatomic Ion Transport Chloride Transport Monoatomic Ion Transmembrane Transport Chloride Transmembrane Transport
Pathways		Transcriptional activation of mitochondrial biogenesis
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483)	Asthma ( 31959851) Breast cancer ( 31757997) Epigenetic age acceleration in alcohol use disorder ( 31466081) Hippocampal volume ( 29274321) Psoriasis ( 25903422) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		3 interacting genes: CLIC6 MCPH1 NRF1	27 interacting genes: ACTB ALDH5A1 ARG2 ATRX CLIC4 DRD2 DRD3 DRD4 EEF1A1 FCGR1A GFPT2 HUWE1 LGI1 MYO1E NFE2L2 NISCH OXR1 PGK1 PKM PPRC1 TAF12 TUBGCP5 UBE4A ZNF18 ZNF224 ZNF234 ZNF439
Entrez ID		23082	54102
HPRD ID		15173	10836
Ensembl ID		ENSG00000148840	ENSG00000159212
Uniprot IDs		E7EVG6 Q5VV67	Q96NY7
PDB IDs
Enriched GO Terms of Interacting Partners?		D2 Dopamine Receptor Binding D4 Dopamine Receptor Binding D3 Dopamine Receptor Binding Third Ventricle Development	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Dopamine Neurotransmitter Receptor Activity Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Regulation Of Dopamine Uptake Involved In Synaptic Transmission Phospholipase C-activating Dopamine Receptor Signaling Pathway Response To Histamine Synaptic Transmission, Dopaminergic Behavioral Response To Cocaine Regulation Of Neurotransmitter Uptake Arachidonate Secretion G Protein-coupled Dopamine Receptor Signaling Pathway Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Dopamine Binding Positive Regulation Of Neurotransmitter Uptake Long-chain Fatty Acid Transport Negative Regulation Of Synaptic Transmission, Glutamatergic Adult Behavior Behavioral Response To Ethanol Regulation Of Dopamine Receptor Signaling Pathway Circadian Regulation Of Gene Expression Negative Regulation Of Cellular Response To Hypoxia Negative Regulation Of Protein Secretion Prepulse Inhibition G Protein-coupled Receptor Internalization Locomotory Behavior Regulation Of Amine Transport Adult Locomotory Behavior Negative Regulation Of Cytosolic Calcium Ion Concentration Ubiquitin-ubiquitin Ligase Activity Response To Morphine Fatty Acid Transport Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Cellular Response To Oxidative Stress Canonical Glycolysis Glycolytic Process Through Glucose-6-phosphate Glycolytic Process Through Fructose-6-phosphate Regulation Of Cellular Response To Hypoxia Regulation Of Dopamine Secretion Rhythmic Process Acid Secretion Secretory Granule Lumen Glucose Catabolic Process Regulation Of Transcription By RNA Polymerase II Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Protein Transport Dopamine Metabolic Process Ficolin-1-rich Granule Lumen Regulation Of Response To Oxidative Stress Response To Amphetamine Regulation Of Cellular Response To Stress
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