UNC13A and EPB41L3

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
BioGRID (two hybrid)

		UNC13A	EPB41L3
Description		unc-13 homolog A	erythrocyte membrane protein band 4.1 like 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Synaptic Vesicle Membrane Neuromuscular Junction Presynaptic Membrane Cell Projection Neuron Projection Terminal Bouton Synapse Presynaptic Active Zone	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Cilium Membrane Cell Junction Axolemma Paranode Region Of Axon Ciliary Basal Body Juxtaparanode Region Of Axon Anchoring Junction Postsynapse Glutamatergic Synapse
	Molecular Function	Calcium Ion Binding Calmodulin Binding Phospholipid Binding Zinc Ion Binding Syntaxin-1 Binding Diacylglycerol Binding Metal Ion Binding	Actin Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Cytoskeletal Protein-membrane Anchor Activity
	Biological Process	Exocytosis Chemical Synaptic Transmission Neurotransmitter Secretion Synaptic Vesicle Docking Synaptic Vesicle Priming Cell Differentiation Synaptic Transmission, Glutamatergic Regulation Of Synaptic Transmission, Glutamatergic Dense Core Granule Priming Neuronal Dense Core Vesicle Exocytosis Positive Regulation Of Dendrite Extension	Protein Localization To Paranode Region Of Axon Apoptotic Process Biological_process Regulation Of Cell Shape Cortical Cytoskeleton Organization Cortical Actin Cytoskeleton Organization Paranodal Junction Assembly Actomyosin Structure Organization Myelin Maintenance Neuron Projection Morphogenesis Protein Localization To Juxtaparanode Region Of Axon Protein Localization To Plasma Membrane Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Pathways			Neurexins and neuroligins Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 19734901 22959728 24931836 27455348 29566793) Amyotrophic lateral sclerosis (sporadic) ( 24256812 28931804) Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals ( 22959728) Benign prostatic hyperplasia ( 30988330) Frontotemporal dementia ( 24931836) IgG levels ( 28628107) Obesity-related traits ( 23251661)	Cerebral amyloid deposition (PET imaging) ( 26252872) Chronic kidney disease ( 31152163) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 30604766 31015462 31152163 31451708) Glomerular filtration rate (creatinine) ( 28452372) Lacunar stroke ( 33773637) Optic nerve head parameters (multi-trait analysis) ( 31798171) Sleep duration ( 25469926) Social communication problems ( 24564958) Thyroid nodules ( 30099483) Vertical cup-disc ratio ( 31798171)
Interacting Genes		2 interacting genes: EPB41L3 UBXN10	20 interacting genes: ATXN1L CADM1 CEP152 CLNS1A CNTNAP2 HSPB1 IGSF21 MBIP MECOM PAXIP1 PSEN1 SPANXN2 SPTBN1 TCF4 UNC13A YWHAB YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		23025	23136
HPRD ID		19058	05622
Ensembl ID		ENSG00000130477	ENSG00000082397
Uniprot IDs		F8VZH8 Q9UPW8	A0A0A0MRA8 A8K968 Q9Y2J2
PDB IDs			2HE7 3BIN 5RYM 5RYN 5RYO 5RYP 5RYQ 5RYR 5RYS 5RYT 5RYU 5RYV 5RYW 5RYX 5RYY 5RYZ 5RZ0 5RZ1 5RZ2 5RZ3 5RZ4 5RZ5 5RZ6 5RZ7 5RZ8 5RZ9 5RZA 5RZB 5RZC 5RZD 5RZE 5RZF 5RZG 5RZH 5RZI 5RZJ 5RZK 5RZL 5RZM 5RZN 5RZO 5RZP 5RZQ 5RZR 5RZS 5RZT 5RZU 5RZV 5RZW 5RZX 5RZY 5RZZ 5S00 6IBE
Enriched GO Terms of Interacting Partners?		Protein Localization To Paranode Region Of Axon Cytoskeletal Protein-membrane Anchor Activity Protein Localization To Juxtaparanode Region Of Axon Juxtaparanode Region Of Axon Paranode Region Of Axon Axolemma Protein Localization To Axon Cilium Paranodal Junction Assembly Myelin Maintenance Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Intraciliary Transport Particle B Cortical Actin Cytoskeleton Organization Regulation Of Receptor Localization To Synapse Regulation Of Protein Localization To Synapse Cell Projection Organization Cortical Cytoskeleton Organization Cytoskeletal Protein Binding	Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Protein Kinase C Inhibitor Activity Protein Domain Specific Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Presynaptic Membrane Phosphoserine Residue Binding Protein Sequestering Activity Transmembrane Transporter Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Establishment Of Protein Localization Synapse Protein Targeting Axolemma Intracellular Protein Localization Regulation Of Metabolic Process Focal Adhesion Insulin-like Growth Factor Receptor Binding Positive Regulation Of Metabolic Process Modulation Of Chemical Synaptic Transmission Regulation Of Primary Metabolic Process Cell Recognition Glutamatergic Synapse Cadherin Binding Positive Regulation Of Lymphocyte Mediated Immunity Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Identical Protein Binding Negative Regulation Of Biosynthetic Process Regulation Of Protein Localization To Nucleus Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Protein Kinase C Signaling Negative Regulation Of Core Promoter Binding Transferase Activity, Transferring One-carbon Groups Thymidylate Synthase Activity Glucocorticoid Catabolic Process Regulation Of Developmental Process Protein Kinase Inhibitor Activity Substantia Nigra Development Neuron Recognition Protein Kinase C Binding Regulation Of Neuron Differentiation Negative Regulation Of Protein Localization To Nucleus
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