UNC13A and EPB41L3

Number of citations of the paper that reports this interaction (PMID 12421765)
28

Data Source:
BioGRID (two hybrid)

		UNC13A	EPB41L3
Gene Name		unc-13 homolog A (C. elegans)	erythrocyte membrane protein band 4.1-like 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cell Junction Axon Neuromuscular Junction Presynaptic Membrane Neuron Projection Presynaptic Active Zone	Cytoplasm Cytoskeleton Plasma Membrane Cell-cell Junction Extrinsic Component Of Membrane Axolemma Paranode Region Of Axon Juxtaparanode Region Of Axon
	Molecular Function	Syntaxin-1 Binding Diacylglycerol Binding Metal Ion Binding Protein N-terminus Binding	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding
	Biological Process	Positive Regulation Of Neurotransmitter Secretion Neurotransmitter Secretion Neuromuscular Junction Development Synaptic Vesicle Docking Synaptic Vesicle Maturation Synaptic Transmission, Glutamatergic Intracellular Signal Transduction Regulation Of Short-term Neuronal Synaptic Plasticity Beta-amyloid Metabolic Process Regulation Of Synaptic Transmission, Glutamatergic Innervation	Protein Localization To Paranode Region Of Axon Apoptotic Process Cytoskeletal Anchoring At Plasma Membrane Biological_process Regulation Of Cell Shape Cortical Cytoskeleton Organization Cortical Actin Cytoskeleton Organization Paranodal Junction Assembly Myelin Maintenance Neuron Projection Morphogenesis Protein Localization To Juxtaparanode Region Of Axon Protein Localization To Plasma Membrane
Pathways
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 22959728 19734901) Obesity-related traits ( 23251661)
Protein-Protein Interactions		1 interactors: EPB41L3	17 interactors: ATXN1L CADM1 CEP152 CLNS1A CNTNAP2 IGSF21 MBIP PAXIP1 PSEN1 SPTBN1 TCF4 UNC13A YWHAB YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		23025	23136
HPRD ID		19058	05622
Ensembl ID		ENSG00000130477	ENSG00000082397
Uniprot IDs		Q9UPW8	A8K968 B7Z4I5 F5GX05 Q9Y2J2
PDB IDs			2HE7 3BIN
Enriched GO Terms of Interacting Partners?		Protein Localization To Paranode Region Of Axon Protein Localization To Juxtaparanode Region Of Axon Cytoskeletal Anchoring At Plasma Membrane Paranodal Junction Assembly Cortical Actin Cytoskeleton Organization Myelin Assembly Myelin Maintenance Cortical Cytoskeleton Organization Cell-cell Junction Assembly Myelination Maintenance Of Protein Location In Cell Protein Localization To Plasma Membrane Axon Ensheathment Maintenance Of Protein Location Maintenance Of Location In Cell Regulation Of Cell Shape Cell Junction Assembly Cell-cell Junction Organization Plasma Membrane Organization Protein Localization To Membrane	Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Positive Regulation Of Intracellular Transport Positive Regulation Of Transport Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Cellular Localization Intrinsic Apoptotic Signaling Pathway Regulation Of Establishment Of Protein Localization Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Organelle Organization Protein Targeting Regulation Of Intracellular Transport Nervous System Development Regulation Of Protein Localization Cellular Localization Membrane Organization System Development Cellular Protein Localization Protein Localization Intracellular Protein Transport Regulation Of Organelle Organization Regulation Of Cellular Component Organization Protein Transport Establishment Of Localization In Cell Apoptotic Process Establishment Of Protein Localization Programmed Cell Death Intracellular Transport Apoptotic Signaling Pathway Cell Death Death Multicellular Organismal Development Regulation Of Synaptic Plasticity Anatomical Structure Development Brain Development Head Development Positive Regulation Of Signal Transduction Intracellular Signal Transduction Cellular Component Assembly Developmental Process Regulation Of Apoptotic Process Central Nervous System Development Regulation Of Cell Death Generation Of Neurons Regulation Of Synaptic Transmission
Tagcloud ?		19p13 8q24 9p21 allocating als amyotrophic c9orf72 causal conditioning conservative converging frontotemporal ftd hits identifies imputation inclusions meta neurotransmitter overlap proven replicated replicating shared sizes spg8 strumpellin tdp topmost
Tagcloud (Difference) ?		19p13 8q24 9p21 allocating als amyotrophic c9orf72 causal conditioning conservative converging frontotemporal ftd hits identifies imputation inclusions meta neurotransmitter overlap proven replicated replicating shared sizes spg8 strumpellin tdp topmost
Tagcloud (Intersection) ?