UNC13A and UBXN10

Number of citations of the paper that reports this interaction (PubMedID 26389662)
53

Data Source:
BioGRID (pull down)

		UNC13A	UBXN10
Description		unc-13 homolog A	UBX domain protein 10
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Synaptic Vesicle Membrane Neuromuscular Junction Presynaptic Membrane Cell Projection Neuron Projection Terminal Bouton Synapse Presynaptic Active Zone	Endoplasmic Reticulum Cilium Intraciliary Transport Particle B Cell Projection
	Molecular Function	Calcium Ion Binding Calmodulin Binding Phospholipid Binding Zinc Ion Binding Syntaxin-1 Binding Diacylglycerol Binding Metal Ion Binding	Protein Binding Ubiquitin Binding
	Biological Process	Exocytosis Chemical Synaptic Transmission Neurotransmitter Secretion Synaptic Vesicle Docking Synaptic Vesicle Priming Cell Differentiation Synaptic Transmission, Glutamatergic Regulation Of Synaptic Transmission, Glutamatergic Dense Core Granule Priming Neuronal Dense Core Vesicle Exocytosis Positive Regulation Of Dendrite Extension	Cell Projection Organization ERAD Pathway Cilium Assembly
Pathways
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 19734901 22959728 24931836 27455348 29566793) Amyotrophic lateral sclerosis (sporadic) ( 24256812 28931804) Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals ( 22959728) Benign prostatic hyperplasia ( 30988330) Frontotemporal dementia ( 24931836) IgG levels ( 28628107) Obesity-related traits ( 23251661)	Group IIA secretory phospholipase A2 levels in individuals with elevated hsCRP ( 31070471)
Interacting Genes		2 interacting genes: EPB41L3 UBXN10	13 interacting genes: APP CLUAP1 IFT46 IFT57 IFT70A IFT70B IFT80 LRRK2 PRMT6 TRAF3IP1 UBXN6 UNC13A VCP
Entrez ID		23025	127733
HPRD ID		19058	18255
Ensembl ID		ENSG00000130477	ENSG00000162543
Uniprot IDs		F8VZH8 Q9UPW8	Q96LJ8
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Localization To Paranode Region Of Axon Cytoskeletal Protein-membrane Anchor Activity Protein Localization To Juxtaparanode Region Of Axon Juxtaparanode Region Of Axon Paranode Region Of Axon Axolemma Protein Localization To Axon Cilium Paranodal Junction Assembly Myelin Maintenance Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Intraciliary Transport Particle B Cortical Actin Cytoskeleton Organization Regulation Of Receptor Localization To Synapse Regulation Of Protein Localization To Synapse Cell Projection Organization Cortical Cytoskeleton Organization Cytoskeletal Protein Binding	Intraciliary Transport Particle B Intraciliary Anterograde Transport Intraciliary Transport Transport Along Microtubule Cytoskeleton-dependent Intracellular Transport Ciliary Tip Microtubule-based Transport Establishment Of Localization In Cell Intracellular Transport Microtubule-based Movement Cellular Localization Microtubule-based Process Cell Projection Cell Projection Organization Cilium Assembly Cilium Organization Ciliary Basal Body Cilium Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Smoothened Signaling Pathway Cellular Component Assembly Plasma Membrane Bounded Cell Projection Organization Intraciliary Transport Particle B Binding Centrosome Ciliary Base Organelle Assembly Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Cellular Response To Manganese Ion Left/right Pattern Formation Response To Manganese Ion Microtubule Organizing Center Golgi-associated Vesicle Regulation Of Wnt Signaling Pathway Cellular Response To Catecholamine Stimulus Syntaxin-1 Binding Response To Catecholamine Negative Regulation Of Keratinocyte Proliferation Regulation Of Proteolysis Organelle Organization Keratinocyte Proliferation Regulation Of Ubiquitin-dependent Protein Catabolic Process Axonemal Microtubule Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of ATP Metabolic Process Anatomical Structure Morphogenesis Terminal Bouton Cytoskeleton Endosome Transport Via Multivesicular Body Sorting Pathway
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