SORCS3 and NGF

Number of citations of the paper that reports this interaction (PMID 15710408)
6

Data Source:
HPRD (in vitro)

		SORCS3	NGF
Gene Name		sortilin-related VPS10 domain containing receptor 3	nerve growth factor (beta polypeptide)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Membrane Integral Component Of Membrane Neuronal Postsynaptic Density	Extracellular Region Extracellular Space Endosome Golgi Lumen Cytoplasmic Membrane-bounded Vesicle
	Molecular Function	Neuropeptide Receptor Activity	Receptor Signaling Protein Activity Nerve Growth Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Neuropeptide Signaling Pathway Learning Memory Regulation Of Long Term Synaptic Depression	Activation Of MAPKK Activity Inflammatory Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Phospholipase C Activity Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Cell-cell Signaling Peripheral Nervous System Development Memory Circadian Rhythm Adult Locomotory Behavior Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Radiation Response To Mechanical Stimulus Response To Ozone Positive Regulation Of Gene Expression Positive Regulation Of Neuron Maturation Sensory Perception Of Pain Positive Regulation Of Protein Autophosphorylation Nerve Growth Factor Processing Response To Lipopolysaccharide Response To Nicotine Nerve Growth Factor Signaling Pathway Response To Drug Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Peptide Hormone Negative Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Axon Extension Negative Regulation Of Cell Cycle Regulation Of Neurotransmitter Secretion Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Neuron Projection Morphogenesis Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To Glucocorticoid Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Neuron Apoptotic Process Response To Electrical Stimulus Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Stem Cell Proliferation Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways			Retrograde neurotrophin signalling Signalling to ERKs Prolonged ERK activation events NF-kB is activated and signals survival p75NTR recruits signalling complexes Axonal growth stimulation Ceramide signalling PI3K/AKT activation p75NTR signals via NF-kB NGF processing NFG and proNGF binds to p75NTR Signalling to p38 via RIT and RIN Signalling by NGF p75NTR regulates axonogenesis p75NTR negatively regulates cell cycle via SC1 Cell death signalling via NRAGE, NRIF and NADE Activation of TRKA receptors p75 NTR receptor-mediated signalling NGF signalling via TRKA from the plasma membrane ARMS-mediated activation TRKA activation by NGF NRIF signals cell death from the nucleus Signalling to RAS NRAGE signals death through JNK Signalling to STAT3 PLC-gamma1 signalling NADE modulates death signalling Frs2-mediated activation
Drugs			Clenbuterol
Diseases
GWAS			Non-alcoholic fatty liver disease ( 23535911)
Protein-Protein Interactions		1 interactors: NGF	8 interactors: A2M CRYAB MMP7 NGFR NTRK1 PLG SORCS3 SORT1
Entrez ID		22986	4803
HPRD ID		12100	08874
Ensembl ID		ENSG00000156395	ENSG00000134259
Uniprot IDs		Q9UPU3	P01138
PDB IDs			1SG1 1WWW 2IFG
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Neuron Maturation Nerve Growth Factor Processing Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Regulation Of Neuron Maturation Response To Ozone Regulation Of Neurotrophin TRK Receptor Signaling Pathway Nerve Growth Factor Signaling Pathway Positive Regulation Of Protein Autophosphorylation Cellular Response To Nerve Growth Factor Stimulus Regulation Of Protein Autophosphorylation Peptide Hormone Processing Response To Nicotine Positive Regulation Of Axon Extension Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Electrical Stimulus Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Neuron Apoptotic Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Neuron Death Activation Of MAPKK Activity Regulation Of Neurotransmitter Secretion Regulation Of Axon Extension Positive Regulation Of Stem Cell Proliferation Positive Regulation Of Axonogenesis Positive Regulation Of Phospholipase Activity Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Sensory Perception Of Pain Extrinsic Apoptotic Signaling Pathway Peripheral Nervous System Development Regulation Of Stem Cell Proliferation Adult Locomotory Behavior Positive Regulation Of Cell Growth Memory Regulation Of Cell Size Phosphatidylinositol-mediated Signaling Response To Alkaloid Peptide Metabolic Process Positive Regulation Of Developmental Growth Response To Glucocorticoid Regulation Of Axonogenesis Regulation Of Ion Homeostasis Positive Regulation Of Cell Morphogenesis Involved In Differentiation Adult Behavior Response To Corticosteroid Circadian Rhythm	Extracellular Matrix Disassembly Nerve Growth Factor Signaling Pathway Cellular Response To Nerve Growth Factor Stimulus Detection Of Temperature Stimulus Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Developmental Programmed Cell Death Cell Differentiation Extracellular Matrix Organization Programmed Cell Death Extracellular Structure Organization Response To Stimulus Regulation Of Endopeptidase Activity Cell Death Death Negative Regulation Of Hydrolase Activity Platelet Degranulation Regulation Of Peptidase Activity Antibacterial Peptide Secretion Antibacterial Peptide Biosynthetic Process Neuropeptide Signaling Pathway Regulation Of Catalytic Activity Nerve Development Muscle Structure Development Negative Regulation Of Complement Activation, Lectin Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cell Proliferation Secretion Regulation Of Long Term Synaptic Depression Mononuclear Cell Migration Negative Regulation Of Hair Follicle Development Regulation Of Proteolysis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Response To Wounding Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Hair Cycle Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Fibrinolysis Circadian Rhythm Detection Of Abiotic Stimulus Negative Regulation Of Catalytic Activity Response To Temperature Stimulus Platelet Activation Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Endosome Transport Via Multivesicular Body Sorting Pathway Regulation Of Cysteine-type Endopeptidase Activity Signal Transduction Axonogenesis Involved In Innervation
Tagcloud ?		anterograde autosomal bdnf cargo cargos coat endosomes frontotemporal golgi intercellular lobar modulate neurodegeneration neurotrophic pleiotropic proneurotrophins retromer sorl1 sortilin sorting summarizes synapse trafficking trk vacuolar vital vps10	afferent antagonist b1 b2 bk blocked cap capsaicin completely cultivation cultured depolarization depolarized dissociated dorsal drg drgs freshly ganglia insensitive microm nerve neurons percentage rat recordings root sensitive small
Tagcloud (Difference) ?		anterograde autosomal bdnf cargo cargos coat endosomes frontotemporal golgi intercellular lobar modulate neurodegeneration neurotrophic pleiotropic proneurotrophins retromer sorl1 sortilin sorting summarizes synapse trafficking trk vacuolar vital vps10	afferent antagonist b1 b2 bk blocked cap capsaicin completely cultivation cultured depolarization depolarized dissociated dorsal drg drgs freshly ganglia insensitive microm nerve neurons percentage rat recordings root sensitive small
Tagcloud (Intersection) ?