PDCD11 and S100A8

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PDCD11	S100A8
Gene Name		programmed cell death 11	S100 calcium binding protein A8
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytosol	Extracellular Region Extracellular Space Nucleus Cytosol Cytoskeleton Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Transcription Factor Binding Poly(A) RNA Binding	Calcium Ion Binding Protein Binding Microtubule Binding Zinc Ion Binding Toll-like Receptor 4 Binding Arachidonic Acid Binding RAGE Receptor Binding
	Biological Process	RRNA Processing MRNA Processing	Cytokine Production Leukocyte Migration Involved In Inflammatory Response Acute Inflammatory Response Chronic Inflammatory Response Positive Regulation Of Peptide Secretion Autophagy Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Response To Zinc Ion Positive Regulation Of Cell Growth Neutrophil Chemotaxis Sequestering Of Zinc Ion Response To Lipopolysaccharide Chemokine Production Wound Healing Defense Response To Bacterium Innate Immune Response Response To Ethanol Positive Regulation Of Inflammatory Response Defense Response To Fungus Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cytoskeleton Organization Neutrophil Aggregation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: NFKB1 RELA S100A8	18 interactors: APP C14orf1 CDKN1A CEACAM3 CHGB GDF9 IGSF21 KLC2 LRIF1 NCF2 PDCD11 PPIA PRMT1 RAB17 S100A9 TP53 TUBA4A UNC119
Entrez ID		22984	6279
HPRD ID		18752	00471
Ensembl ID		ENSG00000148843	ENSG00000143546
Uniprot IDs		Q14690	P05109
PDB IDs		1WI5	1MR8 1XK4 4GGF
Enriched GO Terms of Interacting Partners?		Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Nicotine Regulation Of MiRNA Metabolic Process Regulation Of Interleukin-12 Biosynthetic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Membrane Protein Intracellular Domain Proteolysis Regulation Of Inflammatory Response Response To Lipopolysaccharide Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Molecule Of Bacterial Origin Cellular Response To Interleukin-6 Response To Interleukin-6 Inflammatory Response Membrane Protein Proteolysis Response To Nicotine Cellular Response To Alkaloid Response To Inorganic Substance NIK/NF-kappaB Signaling Response To Bacterium Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Cellular Response To Interleukin-1 Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Interleukin-12 Production TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Response To Other Organism Response To Biotic Stimulus Positive Regulation Of Type I Interferon Production Toll-like Receptor 4 Signaling Pathway Response To Interleukin-1 Innate Immune Response Response To Lipid Regulation Of Cytokine Biosynthetic Process Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway T Cell Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Antigen Receptor-mediated Signaling Pathway Activation Of Innate Immune Response Response To Alkaloid Cellular Response To Lipopolysaccharide Negative Regulation Of Interleukin-12 Biosynthetic Process	Blood Coagulation Hemostasis Platelet Degranulation Immune System Process Stress-induced Premature Senescence Regulation Of Body Fluid Levels Wound Healing Regulation Of Growth Mitotic Cell Cycle Arrest Positive Regulation Of Cellular Protein Metabolic Process Response To Light Stimulus Response To Wounding Regulation Of Cell Growth Positive Regulation Of Protein Metabolic Process Immune Response Negative Regulation Of Cell Growth Response To Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Response To X-ray Cellular Senescence Response To Hyperoxia Platelet Activation Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Mitotic Cell Cycle Phase Transition Ras Protein Signal Transduction Positive Regulation Of Cell Cycle Process Regulation Of Protein Phosphorylation Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Cell Cycle Phase Transition Response To Stimulus Response To Abiotic Stimulus Positive Regulation Of Programmed Cell Death Axon Cargo Transport Negative Regulation Of Growth Response To Stress Positive Regulation Of Cell Death Response To External Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Neuron Apoptotic Process Cellular Response To Ionizing Radiation Signal Transduction Involved In DNA Damage Checkpoint Positive Regulation Of Neuron Apoptotic Process Signal Transduction Involved In Cell Cycle Checkpoint Cellular Response To UV Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Cycle Negative Regulation Of Clathrin-mediated Endocytosis Uncoating Of Virus Mitotic Cell Cycle Process
Tagcloud ?		2c chordin chrdl2 desmin eya2 galectin granulin igfs listed mef2c msh msx1 myocyte myogenesis numb nuprl pax3 pax7 pbx1 programmed pseudospiralis r1 rb1 retinoblastoma satellite ski spiralis trichinella	a9 auscan australian canadian erythrocyte esr exploratory grades hand hip inverse joint kellgren knee lawrence mcmaster narrowing oa ontario osteoarthritis osteophytes sedimentation space stiffness structural sum synovial universities womac
Tagcloud (Difference) ?		2c chordin chrdl2 desmin eya2 galectin granulin igfs listed mef2c msh msx1 myocyte myogenesis numb nuprl pax3 pax7 pbx1 programmed pseudospiralis r1 rb1 retinoblastoma satellite ski spiralis trichinella	a9 auscan australian canadian erythrocyte esr exploratory grades hand hip inverse joint kellgren knee lawrence mcmaster narrowing oa ontario osteoarthritis osteophytes sedimentation space stiffness structural sum synovial universities womac
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