HK1 and ENO2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HK1	ENO2
Gene Name		hexokinase 1	enolase 2 (gamma, neuronal)
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Raft Sperm Principal Piece	Phosphopyruvate Hydratase Complex Photoreceptor Inner Segment Extracellular Space Cytosol Plasma Membrane Perikaryon Extracellular Vesicular Exosome
	Molecular Function	Glucokinase Activity Hexokinase Activity Protein Binding ATP Binding Fructokinase Activity Mannokinase Activity	Magnesium Ion Binding Phosphopyruvate Hydratase Activity
	Biological Process	Cellular Glucose Homeostasis Carbohydrate Metabolic Process Glycolytic Process Hexose Transport Pathogenesis Glucose Transport Hexose Metabolic Process Small Molecule Metabolic Process Carbohydrate Phosphorylation Glucose 6-phosphate Metabolic Process Transmembrane Transport	Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Glycolytic Process Pathogenesis Small Molecule Metabolic Process
Pathways		Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates Glucose transport SLC-mediated transmembrane transport Hexose transport	Gluconeogenesis Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Glycolysis Metabolism of carbohydrates
Drugs		Alpha-D-Glucose-6-Phosphate Beta-D-Glucose Adenosine-5\'-Diphosphate Phosphoaminophosphonic Acid-Adenylate Ester
Diseases
GWAS		Glycated hemoglobin levels ( 20858683 19096518) Hematocrit ( 19862010) Hemoglobin ( 19862010) Mean corpuscular hemoglobin ( 20139978) Mean corpuscular volume ( 20139978) Red blood cell count ( 20139978) Red blood cell traits ( 23222517)
Protein-Protein Interactions		5 interactors: APP ENO2 SCMH1 VDAC1 VDAC2	23 interactors: A2M ACD ANXA11 C16orf45 C6orf47 ENSA EXOC5 HABP4 HK1 HSF1 IL17B MAP4 NAT9 NDUFS7 POT1 SIGIRR SNUPN ST3GAL2 SUMO4 TERF1 TINF2 TUBA4A UBE2C
Entrez ID		3098	2026
HPRD ID		00809	00573
Ensembl ID		ENSG00000156515	ENSG00000111674
Uniprot IDs		A8K7J7 B3KXY9 P19367 P78542 Q59FD4	P09104 Q6FHV6
PDB IDs		1CZA 1DGK 1HKB 1HKC 1QHA 4F9O 4FOE 4FOI 4FPA 4FPB	1TE6 2AKM 2AKZ 3UCC 3UCD 3UJE 3UJF 3UJR 3UJS
Enriched GO Terms of Interacting Partners?		Learning Regulation Of Anion Transport Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Learning Or Memory Axon Choice Point Recognition Cognition	Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Telomere Assembly Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Replication Regulation Of Telomerase Activity Telomere Maintenance Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomere Lengthening Regulation Of DNA Replication Regulation Of DNA Biosynthetic Process Protein Localization To Chromosome, Telomeric Region Telomere Capping Positive Regulation Of Telomerase Activity Mitotic Cell Cycle Process Organelle Organization Cell Division Telomere Maintenance Via Telomerase Negative Regulation Of Telomerase Activity Platelet Degranulation Mitotic Cell Cycle Positive Regulation Of Telomere Maintenance Regulation Of Organelle Organization Cell Cycle Positive Regulation Of DNA Biosynthetic Process Cellular Component Assembly G2/M Transition Of Mitotic Cell Cycle RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Exocytosis Cell Cycle Process Positive Regulation Of DNA Metabolic Process Protein Localization To Chromosome Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Organelle Organization Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Negative Regulation Of Catalytic Activity Mitotic Spindle Checkpoint Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Chromosome Segregation Platelet Activation Cellular Localization Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Negative Regulation Of Protein ADP-ribosylation
Tagcloud ?		cerebellar cerebellum cerebrum changing demonstration detail e14 exception gestational hexokinase hk3 immunoreactivity infiltration isoforms isozymes layers ontogeny organs p45 phosphorylate postnatally prominent purkinje share speculate spleen track vi	begin differentially dige enolase failures gondii gra7 hypothetical imc1 mic2 naturally parasite proteomics pyrimethamine qrt rh rhoptry rop2 rop2a spectrometer spots strains sulfadiazine sulfonamide tga tgh toxoplasma toxoplasmosis undertook
Tagcloud (Difference) ?		cerebellar cerebellum cerebrum changing demonstration detail e14 exception gestational hexokinase hk3 immunoreactivity infiltration isoforms isozymes layers ontogeny organs p45 phosphorylate postnatally prominent purkinje share speculate spleen track vi	begin differentially dige enolase failures gondii gra7 hypothetical imc1 mic2 naturally parasite proteomics pyrimethamine qrt rh rhoptry rop2 rop2a spectrometer spots strains sulfadiazine sulfonamide tga tgh toxoplasma toxoplasmosis undertook
Tagcloud (Intersection) ?