HK1 and ENO2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HK1	ENO2
Description		hexokinase 1	enolase 2
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Membrane Raft	Phosphopyruvate Hydratase Complex Photoreceptor Inner Segment Extracellular Space Cytoplasm Cytosol Plasma Membrane Cell Cortex Cell Surface Membrane Growth Cone Neuronal Cell Body Perikaryon Membrane Raft Extracellular Exosome Synaptic Membrane
	Molecular Function	Nucleotide Binding Catalytic Activity Glucokinase Activity Hexokinase Activity Protein Binding ATP Binding D-glucose Binding Fructokinase Activity Kinase Activity Transferase Activity Phosphotransferase Activity, Alcohol Group As Acceptor Mannokinase Activity Peptidoglycan Binding Glucosamine Kinase Activity	Magnesium Ion Binding Phosphopyruvate Hydratase Activity Protein Binding Lyase Activity Enzyme Binding Identical Protein Binding Protein-containing Complex Binding Metal Ion Binding
	Biological Process	Intracellular Glucose Homeostasis Immune System Process Positive Regulation Of Cytokine Production Involved In Immune Response Carbohydrate Metabolic Process Fructose 6-phosphate Metabolic Process Glucose Metabolic Process Mannose Metabolic Process Glycolytic Process Inflammatory Response GDP-mannose Biosynthetic Process Hexose Metabolic Process Organophosphate Metabolic Process Positive Regulation Of Interleukin-1 Beta Production Innate Immune Response Carbohydrate Phosphorylation Glucose 6-phosphate Metabolic Process Canonical Glycolysis GDP-mannose Biosynthetic Process From Mannose Establishment Of Protein Localization To Mitochondrion Maintenance Of Protein Location In Mitochondrion Carbohydrate Derivative Metabolic Process	Gluconeogenesis Glycolytic Process Response To Xenobiotic Stimulus Response To Estradiol Canonical Glycolysis
Pathways		Synthesis of GDP-mannose Defective HK1 causes hexokinase deficiency (HK deficiency) Glycolysis	Glycolysis Gluconeogenesis
Drugs		alpha-D-glucose 6-phosphate Beta-D-Glucose Phosphoaminophosphonic Acid-Adenylate Ester Lonidamine	2-Phosphoglycolic Acid
Diseases		Anemia due to disorders of glycolytic enzymes, including: Hexokinase (HK) deficiency; Phosphoglycerate kinase 1 (PGK1) deficiency; Triose-phosphate isomerase (TPI) deficiency; Glucose phosphate isomerase (GPI) deficiency; Bisphosphoglycerate mutase (BPGM) deficiency
GWAS		Apolipoprotein B levels ( 32203549) Birth weight ( 31043758) Glycated hemoglobin levels ( 34059833 19096518 31213470 29483669 28898252 20858683) Glycemic traits (pregnancy) ( 23903356) HDL cholesterol levels ( 32203549) Hematocrit ( 19862010 32888494 27863252) Hemoglobin ( 32888494 19862010) Hemoglobin A1c levels ( 29844224 31217584) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 28017375 32327693) hemolysis of donated blood (osmotic) ( 34014839) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Iris color (a* coordinate) ( 29109912) Iris color (b* coordinate) ( 29109912) Iron status biomarkers (ferritin levels) ( 33536631) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Mean corpuscular hemoglobin ( 20139978 27863252 32888494) Mean corpuscular volume ( 27863252 32888494 20139978) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Offspring birth weight ( 31043758) Plateletcrit ( 32888494) Red blood cell count ( 27863252 32888494 20139978) Red blood cell traits ( 23222517) Red cell distribution width ( 27863252 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)
Interacting Genes		6 interacting genes: APP CFTR ENO2 SCMH1 VDAC1 VDAC2	27 interacting genes: A2M ACD AKT1 ANXA11 BMERB1 C6orf47 ENSA EXOC5 HABP4 HK1 HSF1 IL17B MAP4 MTNR1A NAT9 NDUFS7 POT1 SIGIRR SNUPN ST3GAL2 SUMO4 TERF1 TINF2 TUBA4A UBE2C UBE3A USP2-AS1
Entrez ID		3098	2026
HPRD ID		00809	00573
Ensembl ID		ENSG00000156515	ENSG00000111674
Uniprot IDs		A0A994J753 A8K7J7 B3KXY9 P19367 P78542 Q59FD4	P09104 Q6FHV6
PDB IDs		1CZA 1DGK 1HKB 1HKC 1QHA 4F9O 4FOE 4FOI 4FPA 4FPB	1TE6 2AKM 2AKZ 3UCC 3UCD 3UJE 3UJF 3UJR 3UJS 4ZA0 4ZCW 5EU9 5IDZ 5TD9 5TIJ 7MBH
Enriched GO Terms of Interacting Partners?		Membrane Raft Voltage-gated Monoatomic Anion Channel Activity Porin Activity Ceramide Binding Voltage-gated Monoatomic Ion Channel Activity Pore Complex Monoatomic Anion Transmembrane Transport Oxysterol Binding Monoatomic Anion Transport Mitochondrial Transmembrane Transport Phosphatidylcholine Binding Mitochondrial Transport Regulation Of Monoatomic Ion Transmembrane Transport Mitochondrial Nucleoid Cholesterol Binding Lipid Transport Cellular Response To CAMP Amyloid-beta Complex Growth Cone Lamellipodium Synaptic Membrane Enzyme Binding Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Monoatomic Ion Transport Response To CAMP Acetylcholine Receptor Activator Activity Protein-folding Chaperone Binding Lipoprotein Particle Positive Regulation Of Protein Import Positive Regulation Of Anion Channel Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Cell Recognition Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Monoatomic Anion Transport Phosphopyruvate Hydratase Complex Phosphopyruvate Hydratase Activity Negative Regulation Of Calcium Import Into The Mitochondrion Recycling Endosome Regulation Of Reactive Oxygen Species Metabolic Process	Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Telomere Assembly Negative Regulation Of Telomere Maintenance Via Telomerase Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Positive Regulation Of Telomere Maintenance Telomere Maintenance Via Telomerase Translation Elongation Factor Binding Negative Regulation Of Chromosome Organization RNA-templated DNA Biosynthetic Process Negative Regulation Of Cellular Component Organization Regulation Of DNA Biosynthetic Process Positive Regulation Of Organelle Organization Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Positive Regulation Of Chromosome Organization Maintenance Of Protein Location In Mitochondrion Regulation Of Telomere Maintenance Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Chromosome Organization Regulation Of Establishment Of Protein Localization To Chromosome Telomere Organization Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Regulation Of Organelle Organization Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Regulation Of DNA Metabolic Process Telomeric Loop Disassembly Protein Localization To Chromosome, Telomeric Region Chromosome, Telomeric Region Establishment Of Protein Localization To Organelle Organelle Organization DNA Biosynthetic Process Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of Cilium Assembly Cell Division Microtubule Cytoskeleton Ubiquitin-like Protein Ligase Binding Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Mitotic Cell Cycle Regulation Of TRNA Methylation
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