HK1 and VDAC1

Number of citations of the paper that reports this interaction (PMID 10978502)
2

Data Source:
HPRD (in vivo)

		HK1	VDAC1
Gene Name		hexokinase 1	voltage-dependent anion channel 1
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Raft Sperm Principal Piece	Nucleus Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Plasma Membrane Membrane Mitochondrial Nucleoid Pore Complex Extracellular Vesicular Exosome
	Molecular Function	Glucokinase Activity Hexokinase Activity Protein Binding ATP Binding Fructokinase Activity Mannokinase Activity	Protein Binding Voltage-gated Anion Channel Activity Porin Activity Protein Kinase Binding
	Biological Process	Cellular Glucose Homeostasis Carbohydrate Metabolic Process Glycolytic Process Hexose Transport Pathogenesis Glucose Transport Hexose Metabolic Process Small Molecule Metabolic Process Carbohydrate Phosphorylation Glucose 6-phosphate Metabolic Process Transmembrane Transport	Behavioral Fear Response Anion Transport Apoptotic Process Neuron-neuron Synaptic Transmission Learning Viral Process Epithelial Cell Differentiation Regulation Of Anion Transport Transmembrane Transport
Pathways		Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates Glucose transport SLC-mediated transmembrane transport Hexose transport	Mitochondrial protein import
Drugs		Alpha-D-Glucose-6-Phosphate Beta-D-Glucose Adenosine-5\'-Diphosphate Phosphoaminophosphonic Acid-Adenylate Ester
Diseases
GWAS		Glycated hemoglobin levels ( 20858683 19096518) Hematocrit ( 19862010) Hemoglobin ( 19862010) Mean corpuscular hemoglobin ( 20139978) Mean corpuscular volume ( 20139978) Red blood cell count ( 20139978) Red blood cell traits ( 23222517)
Protein-Protein Interactions		5 interactors: APP ENO2 SCMH1 VDAC1 VDAC2	20 interactors: ADRB2 BAK1 BAX BCL2L1 BCL2L11 CKMT1A CKMT1B CSNK2B DYNLT1 DYNLT3 GSN HK1 KLHL40 MCL1 PPIF PRKCE RAF1 SUMO4 TOMM20 TUBA4A
Entrez ID		3098	7416
HPRD ID		00809	05137
Ensembl ID		ENSG00000156515	ENSG00000213585
Uniprot IDs		A8K7J7 B3KXY9 P19367 P78542 Q59FD4	B3KTS5 P21796
PDB IDs		1CZA 1DGK 1HKB 1HKC 1QHA 4F9O 4FOE 4FOI 4FPA 4FPB	2JK4 2K4T
Enriched GO Terms of Interacting Partners?		Learning Regulation Of Anion Transport Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Learning Or Memory Axon Choice Point Recognition Cognition	Apoptotic Mitochondrial Changes Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mitochondrial Membrane Organization Mitochondrial Transport Positive Regulation Of Release Of Cytochrome C From Mitochondria Thymocyte Apoptotic Process B Cell Apoptotic Process Post-embryonic Organ Morphogenesis Positive Regulation Of Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Mitochondrion Organization Mitochondrion Organization Positive Regulation Of Signal Transduction Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Mitochondrion Organization Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway T Cell Apoptotic Process Apoptotic Signaling Pathway Transport Regulation Of Organelle Organization Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Organelle Organization B Cell Negative Selection Apoptotic Process Involved In Morphogenesis Organelle Organization Apoptotic Process Involved In Development Establishment Of Localization In Cell Intracellular Transport Release Of Cytochrome C From Mitochondria Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Mitochondrial Membrane Permeability Involved In Programmed Necrotic Cell Death Apoptotic Process Involved In Embryonic Digit Morphogenesis Post-embryonic Camera-type Eye Morphogenesis Positive Regulation Of Intracellular Signal Transduction Regulation Of Mitochondrial Membrane Potential Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Signal Transduction B Cell Homeostasis Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Developmental Programmed Cell Death Regulation Of Intracellular Signal Transduction Positive Regulation Of Apoptotic Process
Tagcloud ?		cerebellar cerebellum cerebrum changing demonstration detail e14 exception gestational hexokinase hk3 immunoreactivity infiltration isoforms isozymes layers ontogeny organs p45 phosphorylate postnatally prominent purkinje share speculate spleen track vi	000xg calreticulin cd81 centrifugation cleared contaminating devoid dulbecco eagle exosomal exosome exosomes fill fl3 hek293 impacted microsomes nanoparticle nta overnight pelleted phenol purity sedimentation speeds syntenin tsg101 ultracentrifugation vesicle
Tagcloud (Difference) ?		cerebellar cerebellum cerebrum changing demonstration detail e14 exception gestational hexokinase hk3 immunoreactivity infiltration isoforms isozymes layers ontogeny organs p45 phosphorylate postnatally prominent purkinje share speculate spleen track vi	000xg calreticulin cd81 centrifugation cleared contaminating devoid dulbecco eagle exosomal exosome exosomes fill fl3 hek293 impacted microsomes nanoparticle nta overnight pelleted phenol purity sedimentation speeds syntenin tsg101 ultracentrifugation vesicle
Tagcloud (Intersection) ?