TRIM32 and GSN

		TRIM32	GSN
Description		tripartite motif containing 32	gelsolin
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Autophagosome Endoplasmic Reticulum Centrosome Cytosol Striated Muscle Myosin Thick Filament	Podosome Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Actin Cytoskeleton Sarcoplasm Lamellipodium Actin Cap Cortical Actin Cytoskeleton Secretory Granule Lumen Phagocytic Vesicle Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen
	Molecular Function	Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Myosin Binding Protein-macromolecule Adaptor Activity Tat Protein Binding Translation Initiation Factor Binding Identical Protein Binding Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Actin Binding Calcium Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol 3-kinase Catalytic Subunit Binding Myosin II Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Autophagosome Assembly Protein Polyubiquitination Tissue Homeostasis Ubiquitin-dependent Protein Catabolic Process Response To Oxidative Stress Actin Ubiquitination Response To UV Positive Regulation Of Catabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Autophagy Positive Regulation Of Macromolecule Biosynthetic Process Free Ubiquitin Chain Polymerization Protein Ubiquitination Cellular Homeostasis Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Negative Regulation Of Viral Transcription Cellular Response To Stress Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Amino Acid Starvation Response To Tumor Necrosis Factor Response To Starvation Positive Regulation Of Canonical NF-kappaB Signal Transduction Suppression Of Viral Release By Host Innate Immune Response Fat Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Positive Regulation Of DNA-templated Transcription Muscle Cell Cellular Homeostasis Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Neurogenesis Positive Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Protein Metabolic Process Cilium Assembly Axon Development Cytosolic Ciliogenesis Protein K63-linked Ubiquitination Negative Regulation Of Cilium Assembly Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Interleukin-17-mediated Signaling Pathway Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production Protein Localization To Phagocytic Vesicle Positive Regulation Of Cell Motility Positive Regulation Of Autophagosome Assembly	Phagocytosis, Engulfment Actin Filament Organization Central Nervous System Development Actin Polymerization Or Depolymerization Positive Regulation Of Gene Expression Striated Muscle Atrophy Vesicle-mediated Transport Extracellular Matrix Disassembly Cell Projection Organization Cell Projection Assembly Actin Cytoskeleton Organization Actin Filament Polymerization Actin Filament Depolymerization Protein Destabilization Response To Muscle Stretch Positive Regulation Of Apoptotic Process Host-mediated Suppression Of Symbiont Invasion Actin Filament Severing Barbed-end Actin Filament Capping Positive Regulation Of Actin Nucleation Actin Filament Capping Relaxation Of Cardiac Muscle Cilium Assembly Cellular Response To Type II Interferon Regulation Of Podosome Assembly Cardiac Muscle Cell Contraction Renal Protein Absorption Hepatocyte Apoptotic Process Positive Regulation Of Keratinocyte Apoptotic Process Regulation Of Establishment Of T Cell Polarity Regulation Of Plasma Membrane Raft Polarization Regulation Of Receptor Clustering Positive Regulation Of Protein Processing In Phagocytic Vesicle Amyloid Fibril Formation
Pathways		Regulation of innate immune responses to cytosolic DNA Antigen processing: Ubiquitination & Proteasome degradation	Caspase-mediated cleavage of cytoskeletal proteins Neutrophil degranulation Sensory processing of sound by outer hair cells of the cochlea Amyloid fiber formation
Drugs			Zinc Latrunculin A Copper Zinc acetate
Diseases		Bardet-Biedl syndrome (BBS)	Lattice corneal dystrophies (LCD), including: Biber-Haab-Dimmer dystrophy; Familial amyloid polyneuropathy type IV; Meretoja syndrome Familial amyloidosis
GWAS		Estimated glomerular filtration rate ( 31015462) Hip circumference adjusted for BMI ( 34021172)	Blood protein levels ( 30072576)
Interacting Genes		62 interacting genes: ABI2 ATXN1 BTG3 CFTR CLIP4 DERL1 ERGIC3 FADS6 GABARAP GABARAPL1 GABARAPL2 GEM GLIS2 GPR137B HSPA4 ICMT IQCB1 IRAK1 KCTD9 LCN2 MAP1LC3A MAP1LC3B MAP1LC3C MID2 MOB1A MYCN NDRG2 NTAQ1 PDE9A PELI2 PIAS3 PIAS4 PTCD2 PTPN11 RAB29 RABAC1 RNF208 RNF41 SCGB1A1 SDCBP SYT6 TCEANC TOP1 TRIM23 TRIM27 TRIM5 TRIM72 TTC23 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2U UBE2V1 UBQLN1 UBQLN4 VPS11 XIAP	28 interacting genes: ACTA1 ACTB ACTG1 ACTN4 APP AR BCAR1 CASP3 CEBPA CLIC5 CSK ERBB2 FHIT FN1 HSP90AA1 LIMK2 PDE4B PIK3CG PLCG1 PTK2B PXN STK39 TNIK TOM1L1 VASP VCL VDAC1 WEE2-AS1
Entrez ID		22954	2934
HPRD ID		03797	00674
Ensembl ID		ENSG00000119401	ENSG00000148180
Uniprot IDs		Q13049	A0A0A0MS51 A0A0A0MT01 A0A384MEF1 A0A8V8TND7 B7Z4U6 P06396
PDB IDs		2CT2 5FEY	1C0F 1C0G 1D4X 1DEJ 1EQY 1ESV 1H1V 1KCQ 1MDU 1NLV 1NM1 1NMD 1P8X 1P8Z 1SOL 1T44 1YAG 1YVN 2FF3 2FF6 2FH1 2FH2 2FH3 2FH4 3A5L 3A5M 3A5N 3A5O 3CI5 3CIP 3CJB 3CJC 3FFK 3FFN 3TU5 4PKG 4PKH 4PKI 4S10 4Z94 5FAE 5FAF 5H3M 5H3N 5O2Z 5UBO 5ZZ0 6H1F 6JCO 6JEG 6JEH 6LJE 6LJF 6Q9R 6Q9Z 6QBF 6QW3 7P2B 8VIZ 8VKH
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Ubiquitination Cellular Response To Nitrogen Starvation Protein Polyubiquitination Protein Modification Process Phosphatidylethanolamine Binding Ubiquitin-protein Transferase Activity Autophagosome Ubiquitin Protein Ligase Activity Autophagy Protein Metabolic Process Autophagosome Maturation Positive Regulation Of Post-translational Protein Modification Mitophagy Positive Regulation Of Protein Polyubiquitination Protein K63-linked Ubiquitination Autophagy Of Mitochondrion Ubiquitin Protein Ligase Binding Autophagosome Membrane Cellular Response To Nutrient Levels Regulation Of Protein Polyubiquitination Autophagosome Assembly Protein-containing Complex Disassembly Response To Stress Cellular Response To Stress Autophagosome Organization Catabolic Process Positive Regulation Of Protein Ubiquitination Macroautophagy Vacuole Organization Regulation Of Post-translational Protein Modification Protein Binding Macromolecule Metabolic Process Cytoplasmic Vesicle Positive Regulation Of Protein Modification Process Modification-dependent Protein Catabolic Process Protein Monoubiquitination Proteolysis Involved In Protein Catabolic Process Protein K48-linked Ubiquitination Phospholipid Binding Transferase Activity Regulation Of Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Actin Nucleation Positive Regulation Of Protein Metabolic Process Response To Nutrient Levels Regulation Of Macromolecule Metabolic Process Organelle Membrane	Cell Surface Receptor Signaling Pathway Regulation Of Monoatomic Cation Transmembrane Transport Lamellipodium Actin Cytoskeleton Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Locomotion Multicellular Organismal-level Homeostasis Regulation Of Metal Ion Transport Regulation Of Cellular Component Organization Regulation Of Immune System Process Regulation Of Calcium Ion Transmembrane Transport Regulation Of Apoptotic Process Nucleotide Binding Regulation Of Monoatomic Ion Transport Regulation Of Cell Migration Regulation Of Programmed Cell Death Focal Adhesion Extracellular Exosome Positive Regulation Of Immune System Process Anatomical Structure Homeostasis Tissue Homeostasis Regulation Of Cell Adhesion Regulation Of Cell Motility Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cytosol Regulation Of Transport Regulation Of Locomotion Platelet Aggregation Plasma Membrane Regulation Of MAPK Cascade Regulation Of Multicellular Organismal Process ATP Binding Regulation Of Calcium Ion Transport Actin Cytoskeleton Organization Signal Transduction Transmembrane Transporter Binding Positive Regulation Of Gene Expression Identical Protein Binding Homotypic Cell-cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway Actin Filament-based Process Cytoplasm Positive Regulation Of Protein Metabolic Process Cell Motility ERBB Signaling Pathway Cell Body Protein Kinase Binding Positive Regulation Of MAPK Cascade
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