ARL8B and DLEU1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		ARL8B	DLEU1
Gene Name		ADP-ribosylation factor-like 8B	deleted in lymphocytic leukemia 1 (non-protein coding)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Lysosomal Membrane Membrane Midbody Late Endosome Membrane Spindle Midzone Extracellular Vesicular Exosome
	Molecular Function	GTPase Activity GTP Binding GDP Binding Alpha-tubulin Binding Beta-tubulin Binding
	Biological Process	Cell Cycle Chromosome Segregation Small GTPase Mediated Signal Transduction Metabolic Process Cell Division
Pathways
Drugs
Diseases
GWAS		Disc degeneration (lumbar) ( 22993228)	Multiple sclerosis ( 21833088)
Protein-Protein Interactions		7 interactors: AMH APP ATP5J2 BTN3A3 DLEU1 TGFBR1 TUBB	19 interactors: ABCD4 ABCF3 ARL8B CCDC90B COPS6 EEF1A1 EEF1G GDF9 KAT5 KIAA1377 MED31 PSMA1 SETDB1 SHMT1 TLE1 TP53 TUBB4B UBR1 UTP14A
Entrez ID		55207	10301
HPRD ID		12483	16150
Ensembl ID		ENSG00000134108	ENSG00000176124
Uniprot IDs		B4DI85 B4DQT8 Q9NVJ2
PDB IDs		2AL7
Enriched GO Terms of Interacting Partners?		Synaptic Growth At Neuromuscular Junction Preantral Ovarian Follicle Growth Cytoskeleton-dependent Intracellular Transport Regulation Of Protein Binding Sexual Reproduction Collateral Sprouting In Absence Of Injury Immune System Process Male Sex Differentiation Mesenchyme Development Collateral Sprouting Axon Midline Choice Point Recognition Gonad Development Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Development Of Primary Sexual Characteristics Reproduction Axon Choice Point Recognition Oogenesis Stage Regulation Of Binding Leukocyte Mediated Immunity Gonadal Mesoderm Development Mullerian Duct Regression Parathyroid Gland Development Sex Differentiation Neuron Remodeling Immune Response Endothelial Cell Activation Reproductive Process Pathway-restricted SMAD Protein Phosphorylation Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of SMAD Protein Import Into Nucleus Urogenital System Development	DNA Damage Response, Signal Transduction By P53 Class Mediator DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Signal Transduction In Response To DNA Damage DNA Damage Response, Signal Transduction Resulting In Transcription Signal Transduction By P53 Class Mediator Negative Regulation Of Fibroblast Proliferation Viral Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Mitotic Cell Cycle Process Negative Regulation Of Macromitophagy Cellular Response To Leucine Oocyte Growth Oligodendrocyte Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter Water-soluble Vitamin Metabolic Process Mitotic Cell Cycle Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic DNA Damage Checkpoint Negative Regulation Of Helicase Activity Regulation Of Fibroblast Proliferation Regulation Of Cell Cycle Arrest Cell Cycle Cellular Metabolic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Nitrogen Compound Metabolic Process Protein Tetramerization L-serine Catabolic Process Regulation Of Progesterone Secretion Vitamin Metabolic Process Carnitine Biosynthetic Process Positive Regulation Of Protein Modification Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Spindle Organization Positive Regulation Of Thymocyte Apoptotic Process Positive Regulation Of Cell Aging Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Metabolic Process Notch Signaling Pathway Transcription, DNA-templated
Tagcloud ?		akt3 arrays autoantibody capabilities categorizations classification discovery enabled enhance existing expanded exploratory fcgr3a focusing healthy immunoglobulin interest mds reactivity showing signatures stage subgroups supplementing syndromes throughput utilized validated validation	10q23 11q22 12p13 13q14 17p13 21q22 2p23 5q32 6q21 7p12 7q21 8q24 9p13 9p21 9p24 acgh dleu2 ebf1 ikzf1 imbalances interrogate mir145a mir146a mir15a mlpa pax5 probemix uncovering undetected
Tagcloud (Difference) ?		akt3 arrays autoantibody capabilities categorizations classification discovery enabled enhance existing expanded exploratory fcgr3a focusing healthy immunoglobulin interest mds reactivity showing signatures stage subgroups supplementing syndromes throughput utilized validated validation	10q23 11q22 12p13 13q14 17p13 21q22 2p23 5q32 6q21 7p12 7q21 8q24 9p13 9p21 9p24 acgh dleu2 ebf1 ikzf1 imbalances interrogate mir145a mir146a mir15a mlpa pax5 probemix uncovering undetected
Tagcloud (Intersection) ?