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ESRRG
Description
estrogen related receptor gamma
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Nuclear Steroid Receptor Activity
Nuclear Receptor Activity
Steroid Binding
Protein Binding
Zinc Ion Binding
Estrogen Response Element Binding
Identical Protein Binding
Sequence-specific DNA Binding
Metal Ion Binding
AF-2 Domain Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Nuclear Receptor-mediated Steroid Hormone Signaling Pathway
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Retinoic Acid Receptor Signaling Pathway
Positive Regulation Of Cold-induced Thermogenesis
Pathways
Nuclear Receptor transcription pathway
Drugs
Troglitazone
Diethylstilbestrol
Tamoxifen
Cholic Acid
Afimoxifene
4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE
p-Cumylphenol
Bisphenol A
Bisphenol Z
Estradiol acetate
Estradiol benzoate
Estradiol cypionate
Estradiol dienanthate
Estradiol valerate
Diseases
GWAS
Adventurousness (
30643258
)
Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) (
23648065
)
Adverse response to drug (
30420678
)
Alcohol consumption (
23743675
)
Autism (
30675382
)
Breast cancer (
29059683
)
Cardiac hypertrophy (
21348951
)
Cleft lip with or without cleft palate (maternal periconceptional vitamin use interaction) (
29535761
)
Depressive symptom (anhedonia) (ordinal trait) (
31530331
)
Dialysis-related mortality (
21546767
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Energy expenditure (24h) (
28476931
)
General cognitive ability (
29844566
)
General risk tolerance (MTAG) (
30643258
)
Gut microbiota relative abundance (Ruminococcus belonging to family Erysipelotrichaceae) (
33208821
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Intelligence (MTAG) (
29326435
)
Intracranial aneurysm (
29531279
)
LDL cholesterol levels in HIV infection (
33109212
)
Major depressive disorder (
23377640
)
Mean arterial pressure (alcohol consumption interaction) (
24376456
)
Nicotine dependence and major depression (severity of comorbidity) (
30287806
)
Optic nerve measurement (cup area) (
20395239
)
Photic sneeze reflex (
27182965
)
Post bronchodilator FEV1 (
26634245
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Refractive error (
32231278
)
Sleep duration (
25469926
)
Smoking status (ever vs never smokers) (
30643258
)
Tea consumption (
31046077
)
Weight (
28552196
)
Novel Interacting Genes
1 novel interacting genes:
MARK1
Interacting Genes
57 interacting genes:
ADCY4
APP
ARHGEF15
ATM
BPHL
C22orf23
CALM1
CAMK2G
CCDC33
DAXX
DEUP1
DUT
EBP
EFHC2
ESRRA
EXOSC7
FAM107A
FAM9A
FASTK
HGS
HIF1A
KIFC3
LRRK2
MCC
MEOX2
MFHAS1
MRM1
NCOA1
NR0B1
NR0B2
NRIP1
NUP160
PAX6
PNRC1
PNRC2
POMC
PPARGC1A
PPARGC1B
PROX1
PSMC5
RBIS
REL
RINT1
SHTN1
SNIP1
SP1
SRA1
SRPK1
SUMO1P1
TLE1
TNNI1
TNNI2
TRERF1
TULP3
UBL7
VAX1
ZNF438
Entrez ID
2104
HPRD ID
04274
Ensembl ID
ENSG00000196482
Uniprot IDs
B7Z5E9
C0SQ93
F1D8R5
F1D8R6
P62508
PDB IDs
1KV6
1TFC
1VJB
2E2R
2EWP
2GP7
2GPO
2GPP
2GPU
2GPV
2P7A
2P7G
2P7Z
2ZAS
2ZBS
2ZKC
5YSO
6A6K
6I61
6I62
6I63
6I64
6I65
6I66
6I67
6K3N
6KNR
6XXC
6XY5
6Y18
6Y1D
6Y3W
6Y58
8B4Q
8BJG
8BJN
8BM5
8IFO
Enriched GO Terms of Interacting Partners
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Nuclear Receptor Binding
Negative Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Neuroblast Proliferation
Negative Regulation Of Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Protein Binding
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Nucleoplasm
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Steroid Hormone Receptor Signaling Pathway
Nuclear Receptor-mediated Steroid Hormone Signaling Pathway
Regulation Of Macromolecule Metabolic Process
Regulation Of DNA-templated Transcription
Nucleus
Regulation Of RNA Biosynthetic Process
Chromatin
Positive Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Neuroblast Proliferation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of Metabolic Process
Intracellular Signal Transduction
Regulation Of Neural Precursor Cell Proliferation
Neuroblast Proliferation
Nuclear Retinoic Acid Receptor Binding
Regulation Of Nucleobase-containing Compound Metabolic Process
Sequence-specific DNA Binding
Nuclear Retinoid X Receptor Binding
Nuclear Receptor-mediated Signaling Pathway
Regulation Of Transcription By RNA Polymerase II
Transcription Coactivator Activity
Positive Regulation Of Metabolic Process
Regulation Of Metabolic Process
AF-2 Domain Binding
Transcription Corepressor Activity
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Neural Precursor Cell Proliferation
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Hormone-mediated Signaling Pathway
Cytosol
Regulation Of Primary Metabolic Process
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