ESRRG and TRERF1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ESRRG	TRERF1
Description		estrogen related receptor gamma	transcriptional regulating factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Histone Deacetylase Complex Fibrillar Center Nucleus Nucleoplasm Transcription Regulator Complex Cytosol
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding Estrogen Response Element Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding AF-2 Domain Binding Sequence-specific Double-stranded DNA Binding	Transcription Coactivator Binding DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Nuclear Progesterone Receptor Binding Metal Ion Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Progesterone Receptor Signaling Pathway Cellular Response To Progesterone Stimulus
Pathways		Nuclear Receptor transcription pathway
Drugs		Troglitazone Diethylstilbestrol Tamoxifen Cholic Acid Afimoxifene 4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE p-Cumylphenol Bisphenol A Bisphenol Z Estradiol acetate Estradiol benzoate Estradiol cypionate Estradiol dienanthate Estradiol valerate
Diseases
GWAS		Adventurousness ( 30643258) Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) ( 23648065) Adverse response to drug ( 30420678) Alcohol consumption ( 23743675) Autism ( 30675382) Breast cancer ( 29059683) Cardiac hypertrophy ( 21348951) Cleft lip with or without cleft palate (maternal periconceptional vitamin use interaction) ( 29535761) Depressive symptom (anhedonia) (ordinal trait) ( 31530331) Dialysis-related mortality ( 21546767) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Energy expenditure (24h) ( 28476931) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Gut microbiota relative abundance (Ruminococcus belonging to family Erysipelotrichaceae) ( 33208821) Hematocrit ( 32888494) Hemoglobin ( 32888494) Intelligence (MTAG) ( 29326435) Intracranial aneurysm ( 29531279) LDL cholesterol levels in HIV infection ( 33109212) Major depressive disorder ( 23377640) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Optic nerve measurement (cup area) ( 20395239) Photic sneeze reflex ( 27182965) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive error ( 32231278) Sleep duration ( 25469926) Smoking status (ever vs never smokers) ( 30643258) Tea consumption ( 31046077) Weight ( 28552196)	Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Falling risk ( 32999390) HDL cholesterol levels in HIV infection ( 33109212) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Serum total protein levels ( 29403010) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		57 interacting genes: ADCY4 APP ARHGEF15 ATM BPHL C22orf23 CALM1 CAMK2G CCDC33 DAXX DEUP1 DUT EBP EFHC2 ESRRA EXOSC7 FAM107A FAM9A FASTK HGS HIF1A KIFC3 LRRK2 MCC MEOX2 MFHAS1 MRM1 NCOA1 NR0B1 NR0B2 NRIP1 NUP160 PAX6 PNRC1 PNRC2 POMC PPARGC1A PPARGC1B PROX1 PSMC5 RBIS REL RINT1 SHTN1 SNIP1 SP1 SRA1 SRPK1 SUMO1P1 TLE1 TNNI1 TNNI2 TRERF1 TULP3 UBL7 VAX1 ZNF438	8 interacting genes: CREBBP EP300 ESRRG ITCH KEAP1 NEDD4 NR5A1 YAP1
Entrez ID		2104	55809
HPRD ID		04274	11647
Ensembl ID		ENSG00000196482	ENSG00000124496
Uniprot IDs		B7Z5E9 C0SQ93 F1D8R5 F1D8R6 P62508	A0A8Q3SI57 Q05GC8 Q96PN7
PDB IDs		1KV6 1TFC 1VJB 2E2R 2EWP 2GP7 2GPO 2GPP 2GPU 2GPV 2P7A 2P7G 2P7Z 2ZAS 2ZBS 2ZKC 5YSO 6A6K 6I61 6I62 6I63 6I64 6I65 6I66 6I67 6K3N 6KNR 6XXC 6XY5 6Y18 6Y1D 6Y3W 6Y58 8B4Q 8BJG 8BJN 8BM5 8IFO
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Binding Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Neuroblast Proliferation Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Protein Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Positive Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Nucleus Regulation Of RNA Biosynthetic Process Chromatin Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Neuroblast Proliferation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Metabolic Process Intracellular Signal Transduction Regulation Of Neural Precursor Cell Proliferation Neuroblast Proliferation Nuclear Retinoic Acid Receptor Binding Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific DNA Binding Nuclear Retinoid X Receptor Binding Nuclear Receptor-mediated Signaling Pathway Regulation Of Transcription By RNA Polymerase II Transcription Coactivator Activity Positive Regulation Of Metabolic Process Regulation Of Metabolic Process AF-2 Domain Binding Transcription Corepressor Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Hormone-mediated Signaling Pathway Cytosol Regulation Of Primary Metabolic Process	Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Cellular Response To Radiation Histone H3K27 Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Metabolic Process Cellular Response To UV Nucleoplasm Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Localization To Nucleus N-terminal Protein Amino Acid Acetylation Cellular Response To Light Stimulus Peptidyl-lysine Acetylation Regulation Of Cellular Response To Heat Transcription Coregulator Activity Acetyltransferase Activity Chromatin Binding Regulation Of Macromolecule Biosynthetic Process Response To UV Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Response To Radiation Regulation Of Gene Expression Regulation Of Protein Localization To Nucleus Hormone-mediated Signaling Pathway Proline-rich Region Binding Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Chromatin Histone Acetyltransferase Complex Protein-lysine-acetyltransferase Activity Innate Immune Response-activating Signaling Pathway DNA-binding Transcription Factor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of RNA Metabolic Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Histone Acetyltransferase Activity Activation Of Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Protein Catabolic Process Protein Acetylation Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process
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