ATG14 and BECN1

Number of citations of the paper that reports this interaction (PMID 19050071)
111

Data Source:
BioGRID (affinity chromatography technology, pull down)

		ATG14	BECN1
Gene Name		autophagy related 14	beclin 1, autophagy related
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Autophagic Vacuole Axoneme Pre-autophagosomal Structure Membrane ER-mitochondrion Membrane Contact Site Phagocytic Vesicle Extrinsic Component Of Omegasome Membrane Extrinsic Component Of Pre-autophagosomal Structure Membrane	Pre-autophagosomal Structure Nucleus Trans-Golgi Network Cytoplasmic Membrane-bounded Vesicle Extrinsic Component Of Membrane Dendrite Phosphatidylinositol 3-kinase Complex, Class III, Type I Phosphatidylinositol 3-kinase Complex, Class III, Type II Phagocytic Vesicle
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Autophagic Vacuole Assembly Endosome To Lysosome Transport Positive Regulation Of Autophagy Posttranscriptional Regulation Of Gene Expression Macroautophagy Regulation Of Triglyceride Metabolic Process	Autophagic Vacuole Assembly Cytokinesis Response To Hypoxia Cellular Defense Response Cellular Response To Nitrogen Starvation Lysosome Organization Negative Regulation Of Cell Proliferation Positive Regulation Of Autophagy Viral Process Positive Regulation Of Macroautophagy CVT Pathway Response To Vitamin E Response To Drug Negative Regulation Of Apoptotic Process Nucleophagy Late Endosome To Vacuole Transport Neuron Development Beta-amyloid Metabolic Process Regulation Of Catalytic Activity Defense Response To Virus Cellular Response To Aluminum Ion Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Mitochondrion Degradation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: BECN1 EXOC1	15 interactors: AMBRA1 ATG14 ATG3 BCL2 BCL2L1 CASP3 CDKN2A GFI1B GOPC ITCH NEDD4 PIK3R4 TRAF6 WASH1 XPO1
Entrez ID		22863	8678
HPRD ID		13820	05087
Ensembl ID		ENSG00000126775	ENSG00000126581
Uniprot IDs		Q6ZNE5	E7EV84 Q14457
PDB IDs			2P1L 2PON 3DVU 4DDP
Enriched GO Terms of Interacting Partners?		Cellular Response To Aluminum Ion Positive Regulation Of Mitochondrion Degradation CVT Pathway Response To Aluminum Ion Late Endosome To Vacuole Transport Regulation Of Mitochondrion Degradation Positive Regulation Of Macroautophagy Cellular Response To Nitrogen Starvation Response To Vitamin E Nucleophagy Beta-amyloid Metabolic Process Protein Targeting To Vacuole Cellular Response To Epidermal Growth Factor Stimulus Establishment Of Protein Localization To Vacuole Response To Epidermal Growth Factor Positive Regulation Of Autophagy Autophagic Vacuole Assembly Protein Transport Establishment Of Protein Localization Cellular Defense Response Lysosome Organization Macroautophagy Positive Regulation Of Mitochondrion Organization Vacuolar Transport Protein Localization Establishment Of Localization In Cell Regulation Of Mitochondrion Organization Vacuole Organization Response To Vitamin Cytokinesis Regulation Of Autophagy Cellular Localization Cellular Response To Metal Ion Cellular Response To Starvation Cellular Response To Inorganic Substance Peptide Metabolic Process Autophagy Defense Response To Virus Cellular Response To Nutrient Levels Response To Starvation	Regulation Of Cellular Component Organization Apoptotic Mitochondrial Changes Protein K63-linked Ubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Polyubiquitination Cellular Response To Stress Intracellular Transport Intracellular Receptor Signaling Pathway Regulation Of Execution Phase Of Apoptosis Regulation Of Autophagy Regulation Of Organelle Organization Release Of Cytochrome C From Mitochondria Establishment Of Localization In Cell Protein Ubiquitination Apoptotic Process Negative Regulation Of Cellular Metabolic Process Programmed Cell Death Protein Modification By Small Protein Conjugation Regulation Of Cellular Localization Cellular Response To Starvation Cell Death Death Regulation Of T Cell Proliferation Regulation Of Establishment Of Protein Localization Organelle Organization Autophagy Mitochondrion Organization Regulation Of Lymphocyte Activation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cellular Localization Cellular Response To Nutrient Levels Response To Starvation Regulation Of Protein Localization Regulation Of Intracellular Transport Neuron Apoptotic Process Macroautophagy Response To Stress Regulation Of B Cell Proliferation Regulation Of Cell Activation Neuron Death Cellular Response To Extracellular Stimulus Negative Regulation Of T Cell Proliferation Regulation Of Apoptotic DNA Fragmentation Negative Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Regulation Of Apoptotic Process Negative Regulation Of Leukocyte Proliferation
Tagcloud ?		autophagic autophagosome autophagy beclin1 bvdv clean damaged degrade deprivation diarrhea doesn dysfunctional e1 envelope evolutionarily glycoproteins lc3 lentivirus macroautophagy maintains mdbk mechanistic nadl nutrient organelles principally puncta rns serves	antiretroviral antiviral ascribed assemble atg8 autophagic autophagy cargo constitutes defines destruction establishes exemplified explains hitherto machinery nucleate platforms preparation recognizes regulators reminiscent restriction trim trim5 trim5alpha trims tripartite ulk1
Tagcloud (Difference) ?		autophagosome beclin1 bvdv clean damaged degrade deprivation diarrhea doesn dysfunctional e1 envelope evolutionarily glycoproteins lc3 lentivirus macroautophagy maintains mdbk mechanistic nadl nutrient organelles principally puncta rns serves	antiretroviral antiviral ascribed assemble atg8 cargo constitutes defines destruction establishes exemplified explains hitherto machinery nucleate platforms preparation recognizes regulators reminiscent restriction trim trim5 trim5alpha trims tripartite ulk1
Tagcloud (Intersection) ?		autophagic autophagy