NYAP1 and CYFIP1

Number of citations of the paper that reports this interaction (PubMedID 21946561)
80

Data Source:
BioGRID (pull down)

		NYAP1	CYFIP1
Description		neuronal tyrosine phosphorylated phosphoinositide-3-kinase adaptor 1	cytoplasmic FMR1 interacting protein 1
Image		No pdb structure
GO Annotations	Cellular Component		Ruffle Extracellular Region Cytoplasm Cytosol Focal Adhesion Lamellipodium SCAR Complex Cell Leading Edge Secretory Granule Lumen Specific Granule Lumen Cell Projection Neuron Projection Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Postsynapse Tertiary Granule Lumen
	Molecular Function		RNA 7-methylguanosine Cap Binding Actin Binding Protein Binding Translation Repressor Activity Small GTPase Binding Actin Filament Binding
	Biological Process	Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Neuron Projection Morphogenesis	Cell Morphogenesis Regulation Of Translation Nervous System Development Axon Guidance Regulation Of Cell Shape Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Negative Regulation Of Translation Lamellipodium Assembly Cell Differentiation Regulation Of Actin Filament Polymerization Neuron Projection Development Ruffle Organization Axon Extension Cognition Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Dendrite Extension Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways			Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Neutrophil degranulation RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)	Bipolar disorder ( 34099189) Heel bone mineral density ( 30598549) Platelet distribution width ( 32888494) Triglyceride levels x loop diuretics use interaction ( 31806883) World class endurance athleticism ( 32612638)
Interacting Genes		4 interacting genes: CYFIP1 NCKAP1 PIK3R1 TLN1	19 interacting genes: ACTA1 APBB1 EFHC2 EFTUD2 EIF4E FMR1 FXR2 GAS7 GNB1 MEOX1 MYO16 NYAP1 NYAP2 PPP1CC PRPF40A RAC1 RFX6 SCTR TCERG1
Entrez ID		222950	23191
HPRD ID		13427	05890
Ensembl ID		ENSG00000166924	ENSG00000273749
Uniprot IDs		Q6ZVC0	Q7L576
PDB IDs			3P8C 4N78 7USC 7USD 7USE
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Lamellipodium Assembly Regulation Of Lamellipodium Assembly Positive Regulation Of Lamellipodium Organization Regulation Of Lamellipodium Organization Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Ruffle Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation SCAR Complex Positive Regulation Of Actin Nucleation Regulation Of Cell Projection Assembly Regulation Of Actin Filament Organization Rac Protein Signal Transduction Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cortical Actin Cytoskeleton Organization Lamellipodium Assembly Regulation Of Actin Nucleation Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Projection Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Cortical Cytoskeleton Organization Lamellipodium Organization Focal Adhesion Positive Regulation Of Cellular Component Biogenesis Regulation Of Cell-substrate Junction Organization Regulation Of Cytoskeleton Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Actin Filament Polymerization Regulation Of Cell-matrix Adhesion Regulation Of Cellular Component Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Zygotic Determination Of Anterior/posterior Axis, Embryo Basal Protein Localization Intracellular Signaling Cassette Positive Regulation Of Supramolecular Fiber Organization Kinase Regulator Activity Perinuclear Endoplasmic Reticulum Membrane Paraxial Mesoderm Morphogenesis Positive Regulation Of Cytoskeleton Organization Cell Morphogenesis Lamellipodium Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Actin Filament Binding Establishment Or Maintenance Of Actin Cytoskeleton Polarity Regulation Of Translation At Postsynapse Regulation Of Cell-substrate Adhesion Positive Regulation Of Cellular Component Organization Insulin Binding	Cell Projection Morphogenesis Neuron Projection Morphogenesis Cytoplasmic Ribonucleoprotein Granule Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Postsynapse Nuclear Speck MRNA Transport RNA Transport Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synaptic Plasticity Nucleobase-containing Compound Transport RNA Export From Nucleus Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cytoplasmic Stress Granule RNA Binding Developmental Process Modulation Of Chemical Synaptic Transmission Translation Regulator Activity Intracellular Signaling Cassette Nuclear Export Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Protein Secretion Protein-containing Complex Binding Neuron Differentiation RNA Splicing Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Dendritic Spine Development Presynaptic Modulation Of Chemical Synaptic Transmission Cell Projection Organization Eukaryotic Initiation Factor 4G Binding Positive Regulation Of Intracellular Transport Of Viral Material Telomere Tethering At Nuclear Periphery Secretin Receptor Activity Pancreatic Epsilon Cell Differentiation Lamellipodium MRNA Processing Molecular Condensate Scaffold Activity Regulation Of Dendritic Spine Development Dendritic Filopodium Positive Regulation Of Neurogenesis Histone H3 Reader Activity Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Pancreatic D Cell Differentiation
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