BEND7 and LYAR

Number of citations of the paper that reports this interaction (PubMedID 21516116)
20

Data Source:
BioGRID (two hybrid)

		BEND7	LYAR
Description		BEN domain containing 7	Ly1 antibody reactive
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Exosome	Photoreceptor Outer Segment Nucleus Nucleoplasm Nucleolus Cytoplasm Cell Projection
	Molecular Function	DNA Binding Protein Binding	DNA Binding RNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Immune System Process RRNA Processing Innate Immune Response Negative Regulation Of Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase I Erythrocyte Development Positive Regulation Of Phagocytosis
Pathways
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Diastolic blood pressure ( 30224653) Free thyroxine concentration ( 30367059) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) PR interval ( 32439900) Schizophrenia x sex interaction ( 34099189) Skin pigmentation ( 28300201) Smoking status (ever vs never smokers) ( 30643258) White blood cell count ( 32888494)	Disease progression in age-related macular degeneration ( 29346644)
Interacting Genes		75 interacting genes: ANP32B BANF2 BYSL C14orf119 CDC37 CDCA7L CEP44 CHD2 CIB3 CSNK2A1 DDX6 DVL2 DVL3 EAF1 EAF2 EIF1AD EMD FAM124A FAM133A GADD45G GEMIN2 GTPBP3 GYS1 HMBOX1 HSF2BP KANK2 L3MBTL2 LMO3 LNX1 LYAR MAGOHB MBD2 MFAP1 MLX MORF4L1 MORF4L2 MYO15B NAP1L3 NEK6 NIF3L1 NKAPD1 NOL12 NUTF2 OGT OSGIN1 PBLD PIM1 PLEKHF2 POLR3GL PPIG PPP1R37 PRMT3 PRPF40A PSMB1 PSMF1 RAB29 RBM10 RIPPLY1 RPL22 SCNM1 SDCBP SDCBP2 SMARCA2 SPANXN2 THAP1 TLK1 TNPO2 TRIM26 U2AF2 UBL5 USP20 VCX2 WHRN ZCCHC10 ZNF622	16 interacting genes: ADSS1 BEND7 CD2 FGF18 GSK3B OGT PDE4B PHF20L1 PRKRA SDCBP2 SNRPA SREK1IP1 TERF1 TERF2 ZBTB16 ZHX1
Entrez ID		222389	55646
HPRD ID		12570	10064
Ensembl ID		ENSG00000165626	ENSG00000145220
Uniprot IDs		A0AAK2PQJ4 Q8N7W2	Q9NX58
PDB IDs			6ZMI 6ZMO 6ZVH
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Protein Binding RNA Splicing, Via Transesterification Reactions Nuclear Speck MRNA Splicing, Via Spliceosome RNA Splicing RNA Metabolic Process Positive Regulation Of JNK Cascade Sin3-type Complex RNA Processing Nucleic Acid Metabolic Process Non-canonical Inflammasome Complex Assembly Super Elongation Complex Identical Protein Binding Positive Regulation Of Neuron Projection Arborization Frizzled Binding Regulation Of JNK Cascade Transcription Elongation Factor Activity MRNA Processing	Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Shelterin Complex Telomerase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly NSL Complex Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Telomere Capping Positive Regulation Of Chondrocyte Differentiation Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Protein Catabolic Process RNA-templated DNA Biosynthetic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Telomeric DNA Binding Protein Homodimerization Activity Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Cartilage Development Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Telomere Maintenance Identical Protein Binding Nucleoplasm Regulation Of Proteasomal Protein Catabolic Process Regulation Of Microtubule Anchoring At Centrosome Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Telomere Cap Complex Negative Regulation Of Telomere Maintenance Via Recombination Axonal Transport Of Messenger Ribonucleoprotein Complex Negative Regulation Of Telomere Single Strand Break Repair Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Macromolecule Metabolic Process Male Germ Cell Nucleus Regulation Of Chondrocyte Differentiation Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Myeloid Dendritic Cell Activation Negative Regulation Of Metabolic Process Superior Temporal Gyrus Development
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