FGD2 and TMEM239

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		FGD2	TMEM239
Gene Name		FYVE, RhoGEF and PH domain containing 2	transmembrane protein 239
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Lamellipodium Early Endosome Membrane Ruffle Membrane	Integral Component Of Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Small GTPase Binding Metal Ion Binding
	Biological Process	Cytoskeleton Organization Small GTPase Mediated Signal Transduction Regulation Of Cell Shape Actin Cytoskeleton Organization Positive Regulation Of Rho GTPase Activity Positive Regulation Of Apoptotic Process Regulation Of Cdc42 GTPase Activity Positive Regulation Of GTPase Activity Filopodium Assembly Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways		Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS			White matter integrity ( 23218918)
Protein-Protein Interactions		2 interactors: KLHL12 TMEM239	11 interactors: ADCK3 ATF7 C12orf10 CXCL16 FGD2 LENG1 POLI SDCBP SENP2 USP5 WDYHV1
Entrez ID		221472	100288797
HPRD ID		05478
Ensembl ID		ENSG00000146192	ENSG00000198326
Uniprot IDs		Q7Z6J4	Q6ZU23 Q8WW34
PDB IDs
Enriched GO Terms of Interacting Partners?		COPII Vesicle Coating COPII-coated Vesicle Budding Vesicle Targeting, To, From Or Within Golgi Protein Monoubiquitination Localization Within Membrane Vesicle Targeting Membrane Budding ER To Golgi Vesicle-mediated Transport Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Establishment Of Vesicle Localization Vesicle Organization Vesicle Localization Regulation Of Canonical Wnt Signaling Pathway Golgi Vesicle Transport Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Establishment Of Organelle Localization
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