LRRC73 and CTDSP1

Number of citations of the paper that reports this interaction (PubMedID 21653829)
54

Data Source:
BioGRID (two hybrid)

		LRRC73	CTDSP1
Description		leucine rich repeat containing 73	CTD small phosphatase 1
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Extracellular Exosome
	Molecular Function	Protein Binding	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Hydrolase Activity Phosphatase Activity Metal Ion Binding
	Biological Process		Regulation Of Transcription By RNA Polymerase II Protein Dephosphorylation Negative Regulation Of Neuron Differentiation Negative Regulation Of Neurogenesis Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Drugs			Aspartate beryllium trifluoride Citric acid
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 23128233) Mean corpuscular hemoglobin concentration ( 27863252 32888494)
Interacting Genes		9 interacting genes: CTDSP1 ENPP7 GADD45GIP1 LNX1 NTAQ1 PICK1 RPP25 SHANK3 TSHZ3	43 interacting genes: ACTN3 BAG3 CDCA3 CDKN2C CRYBA2 CSF1R CSTF2T FAAP20 FAM110A FANCL FGFR2 GPSM1 GTF2F1 HUNK ITPKB LCK LDB1 LRRC73 LTBP4 MAPKBP1 MBP MORN3 NOXA1 OSTF1 PDZD4 PLEKHM1 POLR2A PTPN11 RAB3IL1 RPRD2 SAXO4 SCNM1 SDCBP SNAI1 STRA8 TEKT4 TRAPPC6A TYRO3 USP29 WWOX YPEL5 ZBTB16 ZSWIM8
Entrez ID		221424	58190
HPRD ID		10167	05615
Ensembl ID		ENSG00000204052	ENSG00000144579
Uniprot IDs		Q3B825 Q5JTD7	Q9GZU7
PDB IDs			1T9Z 1TA0 2GHQ 2GHT 3L0B 3L0C 3L0Y 3PGL 4YGY 4YH1 6DU3
Enriched GO Terms of Interacting Partners?		Regulation Of Synaptic Plasticity Neuron Projection Organization Dendritic Spine Organization Postsynapse Organization Positive Regulation Of Synaptic Transmission, Glutamatergic Receptor Clustering Protein-N-terminal Glutamine Amidohydrolase Activity Positive Regulation Of Intestinal Cholesterol Absorption Protein-N-terminal Asparagine Amidohydrolase Activity Regulation Of Synaptic Transmission, Glutamatergic Guanylate Kinase-associated Protein Clustering Positive Regulation Of Sphingomyelin Catabolic Process Positive Regulation Of Intestinal Lipid Absorption Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Radial Spoke Head 1 Radial Spoke Assembly Radial Spoke Head 3 Positive Regulation Of Phospholipid Catabolic Process Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Supramolecular Fiber Organization Membrane Curvature Sensor Activity Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synaptic Transmission RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Negative Regulation Of Cell Volume Postsynaptic Density Assembly AMPA Glutamate Receptor Clustering Synaptic Receptor Adaptor Activity Regulation Of Synapse Structural Plasticity NMDA Glutamate Receptor Clustering Sperm Flagellum Cilium Movement Involved In Cell Motility Axonemal Central Apparatus Assembly Radial Spoke Head Positive Regulation Of Ceramide Biosynthetic Process Regulation Of Intestinal Cholesterol Absorption Regulation Of Phospholipid Catabolic Process Lipid Digestion Sphingomyelin Phosphodiesterase Activity Negative Regulation Of Actin Nucleation Regulation Of System Process Vocal Learning Neuron Spine Kinocilium Cilium Movement Ribonuclease MRP Complex Positive Regulation Of Long-term Neuronal Synaptic Plasticity Observational Learning
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