FCGR2B and ZBTB18

Data Source: HiPPIP (Novel)

		FCGR2B	ZBTB18
Name		Fc gamma receptor IIb	zinc finger and BTB domain containing 18
Structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Dendritic Spine Cell Body	Heterochromatin Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	Amyloid-beta Binding Protein Binding IgG Receptor Activity Low-affinity IgG Receptor Activity IgG Binding Protein-containing Complex Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Antibody-dependent Cellular Cytotoxicity Negative Regulation Of Type I Hypersensitivity Negative Regulation Of Antibody-dependent Cellular Cytotoxicity Negative Regulation Of Cytokine Production Immune Effector Process Follicular Dendritic Cell Activation Mature B Cell Differentiation Involved In Immune Response Follicular B Cell Differentiation Immune Complex Clearance By Monocytes And Macrophages Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Regulation Of B Cell Antigen Processing And Presentation Negative Regulation Of Immunoglobulin Production Regulation Of Immune System Process Regulation Of Adaptive Immune Response Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Humoral Immune Response Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Receptor-mediated Endocytosis Phagocytosis Phagocytosis, Engulfment Defense Response Inflammatory Response Cell Surface Receptor Signaling Pathway Response To Bacterium Immunoglobulin Mediated Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cerebellum Development Negative Regulation Of B Cell Proliferation Negative Regulation Of Interleukin-10 Production Positive Regulation Of Tumor Necrosis Factor Production Fc-gamma Receptor Signaling Pathway Negative Regulation Of Macrophage Activation Negative Regulation Of Cytotoxic T Cell Degranulation Regulation Of Innate Immune Response Mast Cell Activation Positive Regulation Of JNK Cascade Negative Regulation Of Phagocytosis Positive Regulation Of Phagocytosis Negative Regulation Of Immune Response Negative Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of B Cell Activation Cellular Response To Molecule Of Bacterial Origin Regulation Of Immune Complex Clearance By Monocytes And Macrophages Negative Regulation Of Neutrophil Activation Regulation Of Dendritic Spine Maintenance Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Amyloid-beta Positive Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Dendritic Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Tissue Development Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	None
Drugs		Etanercept Human immunoglobulin G Abciximab Tositumomab Alemtuzumab Antithymocyte immunoglobulin (rabbit) Palivizumab Daclizumab Bevacizumab Sarilumab	None
Diseases		Systemic lupus erythematosus	None
GWAS		Alanine aminotransferase levels ( 34315874 ) Apolipoprotein A1 levels ( 32203549 ) Aspartate aminotransferase levels ( 34315874 33547301 ) Basophil count ( 32888494 ) Basophil percentage of white cells ( 32888494 ) Birth weight ( 27680694 31043758 ) Blood protein levels ( 30072576 ) Granulocyte count ( 27863252 ) HDL cholesterol levels ( 32203549 ) Hemoglobin ( 32888494 ) Hemoglobin concentration ( 27863252 ) IgG levels ( 28628107 ) Inflammatory bowel disease ( 28067908 23128233 ) Lipid metabolism phenotypes ( 22286219 ) Monocyte count ( 32888494 ) Monocyte percentage of white cells ( 27863252 32888494 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 27863252 32888494 ) Offspring birth weight ( 31043758 ) Red blood cell count ( 32888494 ) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576 ) Rheumatoid arthritis ( 30423114 ) Serum total protein levels ( 29403010 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) Systemic lupus erythematosus ( 26502338 ) Ulcerative colitis ( 21297633 28067908 ) White blood cell count ( 32888494 27863252 )	Adventurousness ( 30643258 ) General risk tolerance (MTAG) ( 30643258 ) Mercury levels ( 26025379 )
Interacting Genes		15 interacting genes: APCS BLK CRP ERG28 GAB1 GRB2 INPP5D INPPL1 LY6E LYN MAPK1 MAPK3 PRKCA PTPN11 PTPN6	9 interacting genes: DNMT3A DNMT3B LINC02774 MYLIP PAK1 PIK3R3 POMGNT1 TSN ZBTB2
Entrez ID		2213	10472
HPRD ID		06849	12231
Ensembl ID		ENSG00000072694	ENSG00000179456
Uniprot IDs		P31994	Q99592
PDB IDs		2FCB 3WJJ 5OCC	8P2P
GO Terms Enriched among Interactors		Regulation Of Immune System Process Regulation Of Immune Response Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Immune System Process B Cell Receptor Signaling Pathway Immune Response-activating Signaling Pathway Positive Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Effector Process Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Defense Response Antigen Receptor-mediated Signaling Pathway Activation Of Immune Response Regulation Of Leukocyte Proliferation ERBB Signaling Pathway Regulation Of Cell Activation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Regulation Of Multicellular Organismal Process Negative Regulation Of Immune System Process Bergmann Glial Cell Differentiation SH3 Domain Binding T Cell Costimulation Lymphocyte Mediated Immunity Response To Stress Neutrophil Activation Involved In Immune Response Peptidyl-tyrosine Phosphorylation Innate Immune Response Positive Regulation Of Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Leukocyte Mediated Immunity Cell Surface Receptor Signaling Pathway Glial Cell Development Response To External Biotic Stimulus Schwann Cell Development Positive Regulation Of Multicellular Organismal Process Regulation Of Cell-cell Adhesion Defense Response To Symbiont Negative Regulation Of Lymphocyte Activation Defense Response Leukocyte Mediated Cytotoxicity Regulation Of Lymphocyte Activation Defense Response To Other Organism Insulin Receptor Signaling Pathway Positive Regulation Of Lymphocyte Activation Protein Phosphorylation Intracellular Signal Transduction Regulation Of Lymphocyte Mediated Immunity	DNA (cytosine-5-)-methyltransferase Activity Catalytic Complex DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates Fc Receptor Signaling Pathway Regulation Of B Cell Antigen Processing And Presentation Cerebellum Development Fc-gamma Receptor Signaling Pathway Immune Complex Clearance By Monocytes And Macrophages Negative Regulation Of Type I Hypersensitivity Negative Regulation Of Antibody-dependent Cellular Cytotoxicity Protein-cysteine Methyltransferase Activity Transferase Activity DNA-methyltransferase Activity Regulation Of Immune Complex Clearance By Monocytes And Macrophages Low-affinity IgG Receptor Activity Negative Regulation Of Cytotoxic T Cell Degranulation Follicular Dendritic Cell Activation Immune Complex Clearance Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Beta-1,3-galactosyl-O-glycosyl-glycoprotein Beta-1,3-N-acetylglucosaminyltransferase Activity