KRTAP3-3 and MXD3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRTAP3-3	MXD3
Description		keratin associated protein 3-3	MAX dimerization protein 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament Keratin Filament	Chromatin Nucleus RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Structural Molecule Activity Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Dimerization Activity
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription
Pathways		Keratinization
Drugs
Diseases
GWAS			Activated partial thromboplastin time ( 22703881) Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Diastolic blood pressure ( 30224653) Hip index ( 34021172) Lymphocyte percentage of white cells ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Obesity-related traits ( 23251661) Platelet count ( 32888494) Plateletcrit ( 32888494) Serum uric acid levels ( 30993211) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		78 interacting genes: ALDH3B1 ANAPC11 ARID5A ATG9A BEX2 CELF5 CERCAM CIMAP1B CTSZ CYSRT1 DCANP1 DCDC2B DMRT3 DOCK2 ERMAP FADS6 FAM168A FARS2 FOXC2 FOXH1 FOXP3 GNE GPS2 GSTP1 GUCD1 HOXA1 HR HYPK KLHL38 KRT83 KRTAP10-1 KRTAP12-3 KRTAP12-4 KRTAP13-2 KRTAP15-1 KRTAP19-2 KRTAP19-7 KRTAP4-11 KRTAP4-2 KRTAP5-6 KRTAP6-2 KRTAP9-3 KRTAP9-8 LASP1 LCE1F LCE2B LCE3A LCE3C LCE3D LCE3E LCE4A LONRF1 LRRN4 MGAT5B MRPL23 MXD3 NR1D2 NTAQ1 NUFIP2 OLIG3 OTX1 P2RY6 PATZ1 PHLDA1 PITX1 PITX2 PLSCR3 PLSCR4 PRKAB2 PVR SHISA6 SMARCC1 SSC4D TNFRSF12A VENTX VGLL3 YPEL3 ZNF503	13 interacting genes: CYSRT1 KRT31 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP3-3 MAGEA11 MAX NBPF19 NOTCH2NLA NUP62 SMC3
Entrez ID		85293	83463
HPRD ID		13939	14791
Ensembl ID		ENSG00000212899	ENSG00000213347
Uniprot IDs		Q9BYR6	Q9BW11
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratinization Keratin Filament Epidermis Development Protein Binding Tissue Development Hair Cycle Phospholipid Scramblase Activity Plasma Membrane Phospholipid Scrambling Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding Chromatin	Keratin Filament Intermediate Filament
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