FAM13C and MED4

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		FAM13C	MED4
Name		family with sequence similarity 13 member C	mediator complex subunit 4
Structure		No pdb structure
GO Annotations	Cellular Component	None	Nucleus Nucleoplasm Membrane Mediator Complex Core Mediator Complex
	Molecular Function	Protein Binding	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Nuclear Vitamin D Receptor Binding Nuclear Thyroid Hormone Receptor Binding
	Biological Process	None	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways		None	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
GWAS		Daytime sleep phenotypes ( 27126917 ) Manganese levels ( 26025379 ) Triglyceride levels in HIV infection ( 33109212 )	Proportion of activated microglia (inferior temporal cortex) ( 30679421 ) Thiopurine-induced acute severe leukopenia in inflammatory bowel disease ( 29923122 ) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122 ) Thiopurine-induced early leukopenia in Crohn's disease ( 25108385 ) Thiopurine-induced leukopenia in inflammatory bowel disease ( 29923122 ) Thiopurine-induced severe alopecia in inflammatory bowel disease ( 29923122 ) Thiopurine-induced severe leukopenia in inflammatory bowel disease ( 29923122 )
Novel Interactors		1 novel interactors: BICC1	None recorded
Interacting Genes		14 interacting genes: CCDC172 CCDC85B CEP70 DVL3 HMBOX1 KIF2A MED4 MEOX2 MESD MORF4L1 MTUS2 PHC2 SDCBP2 TFIP11	41 interacting genes: AMOT AP2M1 ATF7IP ATF7IP2 C1orf216 CCDC146 CCHCR1 CEBPA CTDP1 CTNNBL1 FAM13C FOXJ3 FRMD6 FTCD GCC1 HAUS1 HGS IP6K3 ITSN1 KIFC3 LRRFIP1 MAB21L3 MCRS1 MED30 MED9 NDE1 OIP5 PCBD2 PUM2 SDCBP SDCBP2 SGF29 SMARCD1 SMARCE1 SSX3 TLE5 TNFAIP8 TNFAIP8L1 USHBP1 WDTC1 WWP2
Entrez ID		220965	29079
HPRD ID		16875	16145
Ensembl ID		ENSG00000148541	ENSG00000136146
Uniprot IDs		A8K181 B4DSU7 B7Z2K3 Q8NE31	Q9NPJ6
PDB IDs		Not available	7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH
GO Terms Enriched among Interactors		None	Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Transcription Coregulator Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Protein Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of RNA Metabolic Process Positive Regulation Of Exosomal Secretion Regulation Of Modification Of Postsynaptic Structure Brahma Complex NBAF Complex RSC-type Complex NpBAF Complex Kinetochore Centrosome Regulation Of DNA-templated Transcription Initiation Regulation Of Exosomal Secretion Regulation Of Modification Of Synaptic Structure Nucleosome Disassembly Regulation Of Embryonic Development