SLC16A9 and EIF4A2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		SLC16A9	EIF4A2
Description		solute carrier family 16 member 9	eukaryotic translation initiation factor 4A2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Cytosol Eukaryotic Translation Initiation Factor 4F Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Creatine Transmembrane Transporter Activity Protein Binding Monocarboxylic Acid Transmembrane Transporter Activity Carnitine Transmembrane Transporter Activity Symporter Activity Transmembrane Transporter Activity	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity
	Biological Process	Creatine Transmembrane Transport Urate Metabolic Process Transmembrane Transport Carnitine Transmembrane Transport Carboxylic Acid Transmembrane Transport	Cytoplasmic Translational Initiation Translation Translational Initiation Regulation Of Translational Initiation Negative Regulation Of RNA-dependent RNA Polymerase Activity Cellular Response To Leukemia Inhibitory Factor
Pathways			ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Appendicular lean mass ( 33097823) Gout ( 33832965 31578528) HDL cholesterol levels ( 32203549) Hemoglobin ( 32888494) Manganese levels ( 26025379) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Metabolic traits ( 21886157) Metabolite levels ( 23823483) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Platelet distribution width ( 32888494) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 33031748 23093944) Serum metabolite ratios in chronic kidney disease ( 29545352) Serum uric acid levels ( 30993211) Systolic blood pressure (alcohol consumption interaction) ( 24376456) Total carotid plaque area (excess vs minimal atherosclerosis) ( 32811377) Triglyceride levels ( 32203549) Urate levels ( 31578528 23263486) Uric acid levels ( 19503597)
Interacting Genes		3 interacting genes: EIF4A2 KLC4 MRPL11	25 interacting genes: BRCA1 CLNS1A DPPA4 ECT2 EIF4G1 EIF4G2 FTCD GOLGA2 HSPB2 IPO11 LINC01554 MCPH1 MDFI NEK2 PDCD4 PFDN1 PIH1D2 RIPPLY3 SLC16A9 SSX2IP SUMO2 TK1 TRIM36 TRIM39 ZNF620
Entrez ID		220963	1974
HPRD ID		15348	03062
Ensembl ID		ENSG00000165449	ENSG00000156976
Uniprot IDs		Q7RTY1	Q14240
PDB IDs			3BOR
Enriched GO Terms of Interacting Partners?		Negative Regulation Of RNA-dependent RNA Polymerase Activity Translation Large Ribosomal Subunit RRNA Binding Eukaryotic Translation Initiation Factor 4F Complex	Centrosome Cycle Regulation Of Cell Cycle Eukaryotic Translation Initiation Factor 4F Complex Microtubule Organizing Center Organization
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