ITIH2 and ATP5C1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ITIH2	ATP5C1
Gene Name		inter-alpha-trypsin inhibitor heavy chain 2	ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Vesicular Exosome Blood Microparticle	Mitochondrial Proton-transporting ATP Synthase Complex, Catalytic Core F(1) Mitochondrion Mitochondrial Inner Membrane Mitochondrial Proton-transporting ATP Synthase Complex Mitochondrial Matrix Membrane Extracellular Vesicular Exosome
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity	ATPase Activity Transmembrane Transporter Activity Poly(A) RNA Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism Proton-transporting ATPase Activity, Rotational Mechanism
	Biological Process	Negative Regulation Of Endopeptidase Activity Hyaluronan Metabolic Process	Oxidative Phosphorylation ATP Biosynthetic Process Respiratory Electron Transport Chain Mitochondrial ATP Synthesis Coupled Proton Transport Cellular Metabolic Process Small Molecule Metabolic Process
Pathways			Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. The citric acid (TCA) cycle and respiratory electron transport Formation of ATP by chemiosmotic coupling
Drugs
Diseases
GWAS		Ovarian reserve ( 22116950)
Protein-Protein Interactions		3 interactors: ATP5C1 FCER1A SPINT2	23 interactors: APP ATP5A1 ATP5B CA12 CCND3 CCT7 CHMP2B DPP3 EGFR ELOF1 GDPD2 ITIH2 MED15 MPP1 NDUFB3 NGEF PAWR PJA1 PNO1 POLA2 PTN SERPINA1 ZNF337
Entrez ID		3698	509
HPRD ID		00890	00156
Ensembl ID		ENSG00000151655	ENSG00000165629
Uniprot IDs		P19823	P36542 Q8TAS0
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Interleukin-3 Biosynthetic Process Positive Regulation Of Type I Hypersensitivity Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Serotonin Secretion Serotonin Transport Positive Regulation Of Hypersensitivity Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Mast Cell Degranulation Positive Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Mast Cell Activation Mitochondrial ATP Synthesis Coupled Proton Transport Monovalent Inorganic Cation Transport Positive Regulation Of Regulated Secretory Pathway Leukotriene Biosynthetic Process Monoamine Transport Regulation Of Mast Cell Degranulation Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Calcium-mediated Signaling ATP Synthesis Coupled Proton Transport Leukotriene Metabolic Process Positive Regulation Of Immunoglobulin Mediated Immune Response Regulation Of Mast Cell Activation Activation Of JUN Kinase Activity Regulation Of Regulated Secretory Pathway ATP Biosynthetic Process Regulation Of Calcium-mediated Signaling Icosanoid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Cation Transport Positive Regulation Of Exocytosis Positive Regulation Of Cytokine Biosynthetic Process Ammonium Transport Positive Regulation Of JUN Kinase Activity Oxidative Phosphorylation Regulation Of Acute Inflammatory Response Purine Ribonucleoside Monophosphate Biosynthetic Process Regulation Of JUN Kinase Activity Nucleoside Triphosphate Biosynthetic Process JNK Cascade Ribonucleoside Monophosphate Biosynthetic Process Positive Regulation Of Inflammatory Response Icosanoid Metabolic Process	Mitochondrial ATP Synthesis Coupled Proton Transport Respiratory Electron Transport Chain Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Electron Transport Chain ATP Metabolic Process ATP Synthesis Coupled Proton Transport Cellular Respiration ATP Biosynthetic Process Alkanesulfonate Metabolic Process Response To Methanol Purine Nucleoside Metabolic Process Ion Homeostasis Nucleotide Metabolic Process Negative Regulation Of Endopeptidase Activity Learning Or Memory Negative Regulation Of Peptidase Activity ATP Hydrolysis Coupled Proton Transport Synaptic Growth At Neuromuscular Junction Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Response To Triglyceride Astrocyte Activation Platelet Degranulation Purine Ribonucleoside Monophosphate Biosynthetic Process Ossification Positive Regulation Of Cell Cycle Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cognition Ribonucleotide Metabolic Process Nucleoside Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Nucleobase-containing Small Molecule Metabolic Process Purine Nucleotide Metabolic Process Regulation Of ERBB Signaling Pathway Negative Regulation Of Dendritic Spine Morphogenesis Collateral Sprouting In Absence Of Injury Nucleoside Triphosphate Biosynthetic Process Ribose Phosphate Metabolic Process Cell Activation Ribonucleoside Monophosphate Biosynthetic Process Small Molecule Metabolic Process Activation Of Phospholipase A2 Activity Response To Chromate Negative Regulation Of Proteolysis Cellular Metabolic Process Regulation Of Catalytic Activity Nucleobase-containing Compound Metabolic Process Nucleoside Monophosphate Biosynthetic Process Negative Regulation Of Protein Processing Cellular Localization
Tagcloud ?		5mg breakdown bred conceptus corn cypionate ecm endometrial endometrium expresses gestation gilts glycocalyx hyaluronic il6 le linker lumenal microvilli pge pig snap surgically tnfaip6 trt trypsin uterine uterus	3xflag compatible created creating ddost deleted dissociated envelope immunolocalization knock mammals persists phosphatases pp1 ppp1ca ppp1cb ppp1cc ppp1cc1 ppp1cc2 reciprocal sbp sedimentation spermatogenesis spermatogenic splice tagged tandem testis ubiquitously
Tagcloud (Difference) ?		5mg breakdown bred conceptus corn cypionate ecm endometrial endometrium expresses gestation gilts glycocalyx hyaluronic il6 le linker lumenal microvilli pge pig snap surgically tnfaip6 trt trypsin uterine uterus	3xflag compatible created creating ddost deleted dissociated envelope immunolocalization knock mammals persists phosphatases pp1 ppp1ca ppp1cb ppp1cc ppp1cc1 ppp1cc2 reciprocal sbp sedimentation spermatogenesis spermatogenic splice tagged tandem testis ubiquitously
Tagcloud (Intersection) ?