SAXO4 and PRDM14

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SAXO4	PRDM14
Description		stabilizer of axonemal microtubules 4	PR/SET domain 14
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Cilium Motile Cilium Ciliary Basal Body Sperm Flagellum Cell Projection Axonemal A Tubule Inner Sheath	Nucleus Nucleoplasm
	Molecular Function	Protein Binding Phosphatase Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding RNA Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Chromatin DNA Binding Metal Ion Binding Methyltransferase Regulator Activity Histone Methyltransferase Binding
	Biological Process	Flagellated Sperm Motility	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Cell Fate Specification Inner Cell Mass Cell Fate Commitment Regulation Of Transcription By RNA Polymerase II Germ Cell Development Embryo Implantation Fibroblast Growth Factor Receptor Signaling Pathway Fertilization Regulation Of Gene Expression Stem Cell Population Maintenance Germ-line Stem Cell Population Maintenance Methylation Epigenetic Regulation Of Gene Expression Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Gene Expression, Epigenetic Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Flagellated Sperm Motility Positive Regulation Of Stem Cell Population Maintenance
Pathways			Transcriptional regulation of pluripotent stem cells
Drugs
Diseases
GWAS			Schizophrenia ( 30285260) Testicular germ cell tumor ( 23666240 28604728 28604732)
Interacting Genes		73 interacting genes: AKAP8L ALS2CL APP ATN1 ATPAF2 B9D2 BAG4 BCAS2 C10orf55 CATSPER1 CCDC57 CFTR COG6 COX5B CSTF2 CTDSP1 CYSRT1 DTX2 FAM168B FHL2 FHL3 FHL5 FKBP6 FRS3 GOLGA2 HGS HNRNPH1 HOMER3 HOXA1 HSF2BP INCA1 KCTD9 KPRP KRT31 KRTAP13-2 KRTAP19-5 KRTAP19-6 KRTAP3-1 KRTAP3-2 KRTAP6-2 KRTAP6-3 KRTAP8-1 LASP1 LMO2 LMO4 METTL27 MYO15B OIP5 OTUD7B PFDN5 PLA2G10 PLEKHG4 PLEKHN1 PPP1CA PPP1CC PRDM14 PRKAA2 QARS1 RBM11 RFX6 RIMBP3C SLAIN1 TEKT4 TFG TGM7 TRAF1 TRAF2 TRIB3 TSC1 UNKL VMAC WWOX ZMYND12	67 interacting genes: ABI2 AKAP9 AQP1 ATPAF2 BAG4 BAHD1 BCAR3 BEX2 CARD10 CASP8 CDCA7L CHEK2 CREB5 DGCR6 DMRT3 DRC4 EED EIF4E2 ENKD1 ERBB2 EZH2 FAM83A GEM GLYCTK GPATCH2L HEXIM2 HOXB5 HOXC8 HSP90AA2P HSPA5 HSPB7 ID3 IDH1 KANK2 LNX1 MIA3 MRPL32 MYPOP PALB2 PATZ1 PAX2 PLEKHF2 PRKAB2 PRPF31 PSMA1 PTPRJ RAD51D RBM10 RCOR3 RUSC1 SAXO4 SCNM1 SNRPC SUZ12 TCAF1 TEAD4 TEKT4 TLE5 TRIM41 TSGA10 TTC32 TXK USP2 WDR25 ZNF250 ZNF587 ZNF835
Entrez ID		220004	63978
HPRD ID		16933	11457
Ensembl ID		ENSG00000162148	ENSG00000147596
Uniprot IDs		G3F4G3 Q7Z5V6	Q9GZV8
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Protein Binding	Chromatin Silencing Complex Protein Binding Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Ubiquitin Protein Ligase Binding Oligodendrocyte Differentiation ESC/E(Z) Complex Facultative Heterochromatin Formation Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Glial Cell Differentiation Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Identical Protein Binding Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Anoikis Pronucleus Sex Chromatin Negative Regulation Of Transcription By RNA Polymerase II
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