JOSD1 and DNAL4

		JOSD1	DNAL4
Description		Josephin domain containing 1	dynein axonemal light chain 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane	Cytoplasm Cytoskeleton Microtubule Plasma Membrane Cilium Dynein Complex Cell Projection
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Hydrolase Activity Deubiquitinase Activity	Microtubule Motor Activity Protein Binding Identical Protein Binding
	Biological Process	Proteolysis Endocytosis Protein Deubiquitination Membrane Biogenesis Cell Motility Membrane Organization	Microtubule-based Process Microtubule-based Movement
Pathways		Josephin domain DUBs	Retrograde neurotrophin signalling
Drugs
Diseases
GWAS		Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Plateletcrit ( 32888494) Resting heart rate ( 27798624) Sleep duration ( 30846698)
Interacting Genes		38 interacting genes: ADAMTSL4 CARD10 CYSRT1 FBLN2 KRT27 KRT31 KRT34 KRT40 KRT86 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-4 KRTAP10-8 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP5-9 KRTAP9-2 KRTAP9-3 LNX1 MDFI MID2 MTUS2 NBPF19 NOTCH2NLA PJA1 STUB1 TGM1 TRAF1 TRIM23 TRIM27 TRIM54 TRIM63 UBC USP15 USP21 USP28	14 interacting genes: CHIC2 DYNLL2 FHL5 GNA14 GPBP1 KRTAP10-3 KRTAP12-3 KRTAP9-8 NFATC2IP NOTCH2NLA NTAQ1 NUDT22 SCTR TRIM54
Entrez ID		9929	10126
HPRD ID		08823	13239
Ensembl ID		ENSG00000100221	ENSG00000100246
Uniprot IDs		Q15040	O96015
PDB IDs
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Identical Protein Binding Intermediate Filament Organization Ubiquitin Protein Ligase Activity Post-translational Protein Modification Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Cytosol Protein Modification Process Ubiquitin-protein Transferase Activity Epidermis Development Negative Regulation Of Viral Transcription Positive Regulation Of Autophagy Suppression Of Viral Release By Host Structural Molecule Activity Supramolecular Fiber Organization Regulation Of Viral Transcription Microtubule Cysteine-type Deubiquitinase Activity Protein Deubiquitination Deubiquitinase Activity
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