FAP and PLAUR

Number of citations: 0 (PubMedID 12376466)
Data Source: BioGRID (fluorescent resonance energy transfer), HPRD (in vitro, in vivo)

		FAP	PLAUR
Name		fibroblast activation protein alpha	plasminogen activator, urokinase receptor
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Focal Adhesion Cell Surface Membrane Lamellipodium Lamellipodium Membrane Ruffle Membrane Cell Projection Apical Part Of Cell Basal Part Of Cell Anchoring Junction Peptidase Complex	Extracellular Region Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Extrinsic Component Of Membrane Specific Granule Membrane Cell Projection Anchoring Junction Side Of Membrane Protein Complex Involved In Cell-matrix Adhesion Serine-type Endopeptidase Complex
	Molecular Function	Protease Binding Endopeptidase Activity Serine-type Endopeptidase Activity Integrin Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Dipeptidyl-peptidase Activity Hydrolase Activity Identical Protein Binding Protein Homodimerization Activity	Signaling Receptor Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Urokinase Plasminogen Activator Receptor Activity Signaling Receptor Activity
	Biological Process	Angiogenesis Proteolysis Apoptotic Process Cell Adhesion Regulation Of Collagen Catabolic Process Negative Regulation Of Extracellular Matrix Disassembly Endothelial Cell Migration Proteolysis Involved In Protein Catabolic Process Regulation Of Cell Cycle Regulation Of Fibrinolysis Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Melanocyte Proliferation Positive Regulation Of Execution Phase Of Apoptosis Melanocyte Apoptotic Process Negative Regulation Of Extracellular Matrix Organization	Positive Regulation Of Protein Phosphorylation Chemotaxis Signal Transduction Blood Coagulation Regulation Of Plasminogen Activation Regulation Of Cell Adhesion Regulation Of Proteolysis Positive Regulation Of Homotypic Cell-cell Adhesion Urokinase Plasminogen Activator Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of DNA Binding Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Fibrinolysis Positive Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		None	Attachment of GPI anchor to uPAR Neutrophil degranulation Dissolution of Fibrin Clot
Drugs		Sibrotuzumab	Urokinase Tenecteplase WX-UK1 Lanoteplase
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Coronary artery disease ( 33020668 ) Estimated glomerular filtration rate ( 30604766 ) Glomerular filtration rate ( 29403010 ) Inflammatory skin disease ( 25574825 ) Medication use (thyroid preparations) ( 31015401 ) Regular attendance at a pub or social club ( 29970889 ) Systemic lupus erythematosus ( 28714469 33272962 )	Basophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Granulocyte count ( 27863252 ) Granulocyte percentage of myeloid white cells ( 27863252 ) HDL cholesterol levels ( 32203549 ) Lymphocyte count ( 32888494 ) Lymphocyte percentage of white cells ( 27863252 32888494 ) Monocyte percentage of white cells ( 27863252 32888494 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 27863252 32888494 ) Neutrophil percentage of granulocytes ( 27863252 ) Neutrophil percentage of white cells ( 27863252 32888494 ) Plateletcrit ( 32888494 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) White blood cell count ( 32888494 27863252 )
Interacting Genes		2 interacting genes: DPP4 PLAUR	22 interacting genes: CRYAA DYRK1A EEF1A1 ELAVL1 FAP FYN HCK IGF2R IL6ST ITGAM ITGB1 JAK1 KNG1 LRP1 LRP1B MMP12 PFN2 PLAU SRPX2 SURF2 TYK2 VTN
Entrez ID		2191	5329
HPRD ID		02674	01421
Ensembl ID		ENSG00000078098	ENSG00000011422
Uniprot IDs		B4DLR2 Q12884	M0R1I2 Q03405
PDB IDs		1Z68 6Y0F 9DVQ 9DVR	1YWH 2FD6 2I9B 3BT1 3BT2 3U73 3U74 4K24 4QTI 7E17 7V63
GO Terms Enriched among Interactors		Multicellular Organismal Response To Stress Glucagon Processing General Adaptation Syndrome Urokinase Plasminogen Activator Receptor Activity Intercellular Canaliculus Positive Regulation Of Cell-cell Adhesion Adhesion Of Symbiont To Host Signaling Receptor Binding Locomotion Negative Regulation Of Extracellular Matrix Disassembly Locomotory Behavior Anchoring Junction Adhesion Of Symbiont To Host Cell Receptor-mediated Endocytosis Of Virus By Host Cell Response To Hypoxia Receptor-mediated Virion Attachment To Host Cell Negative Regulation Of Neutrophil Migration Regulation Of Cell-cell Adhesion Mediated By Integrin Response To Oxygen Levels Negative Regulation Of Neutrophil Chemotaxis Dipeptidyl-peptidase Activity Response To Decreased Oxygen Levels Psychomotor Behavior Virion Attachment To Host Cell Chemotaxis Endocytosis Involved In Viral Entry Into Host Cell Midbrain Dopaminergic Neuron Differentiation Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Habenula Development Nuclear Glucocorticoid Receptor Binding Cellular Response To Corticotropin-releasing Hormone Stimulus Dopamine Biosynthetic Process Serine-type Endopeptidase Complex Protein Complex Involved In Cell-matrix Adhesion Urokinase Plasminogen Activator Signaling Pathway Piccolo Histone Acetyltransferase Complex Locomotory Exploration Behavior Focal Adhesion Nuclear Retinoid X Receptor Binding Regulation Of Fibrinolysis Regulation Of Plasminogen Activation Catecholamine Biosynthetic Process Positive Regulation Of Homotypic Cell-cell Adhesion Extrinsic Component Of Membrane Regulation Of Dopamine Metabolic Process Positive Regulation Of Cell Adhesion Negative Regulation Of Leukocyte Chemotaxis	Non-membrane Spanning Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Receptor Complex Protein Tyrosine Kinase Activity Focal Adhesion Regulation Of Metabolic Process Peptidyl-tyrosine Phosphorylation Regulation Of Wound Healing Type II Interferon-mediated Signaling Pathway Regulation Of Fibrinolysis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Blood Coagulation Cell Surface Receptor Signaling Pathway Regulation Of Hemostasis Regulation Of Smooth Muscle Cell Migration Regulation Of Response To Wounding Receptor-mediated Endocytosis Regulation Of Multicellular Organismal Process Cell Motility Protein Phosphorylation Regulation Of Cell Adhesion Membrane Raft Phosphorylation Extracellular Space Integrin-mediated Signaling Pathway Regulation Of Collagen Catabolic Process Regulation Of Protein Metabolic Process Cell Migration Plasma Membrane Endocytosis Regulation Of Cell Migration Positive Regulation Of Multicellular Organismal Process Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Cell Motility Interleukin-11-mediated Signaling Pathway Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Protein Kinase Activity Integrin Binding Negative Regulation Of Coagulation Regulation Of Locomotion Protein Complex Involved In Cell-matrix Adhesion Response To Amyloid-beta Growth Hormone Receptor Binding Interleukin-10-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Developmental Process Positive Regulation Of Wound Healing Positive Regulation Of Reactive Oxygen Species Metabolic Process Cell Surface Receptor Signaling Pathway Via JAK-STAT