FAP and PLAUR

Number of citations of the paper that reports this interaction (PMID 12376466)
10

Data Source:
BioGRID (fluorescent resonance energy transfer)
HPRD (in vivo, in vitro)

		FAP	PLAUR
Gene Name		fibroblast activation protein, alpha	plasminogen activator, urokinase receptor
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Plasma Membrane Focal Adhesion Cell Surface Integral Component Of Membrane Lamellipodium Lamellipodium Membrane Ruffle Membrane Apical Part Of Cell Basal Part Of Cell Invadopodium Membrane	Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Integral Component Of Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Extracellular Vesicular Exosome Invadopodium Membrane
	Molecular Function	Protease Binding Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Integrin Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Dipeptidyl-peptidase Activity Protein Homodimerization Activity Protein Dimerization Activity	Receptor Activity Receptor Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Urokinase Plasminogen Activator Receptor Activity
	Biological Process	Angiogenesis Proteolysis Cell Adhesion Regulation Of Collagen Catabolic Process Negative Regulation Of Extracellular Matrix Disassembly Endothelial Cell Migration Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Fibrinolysis Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Positive Regulation Of Cell Cycle Arrest Mitotic Cell Cycle Arrest Melanocyte Proliferation Positive Regulation Of Execution Phase Of Apoptosis Melanocyte Apoptotic Process Negative Regulation Of Extracellular Matrix Organization	C-terminal Protein Lipidation Movement Of Cell Or Subcellular Component Chemotaxis Signal Transduction Blood Coagulation Attachment Of GPI Anchor To Protein Regulation Of Proteolysis Urokinase Plasminogen Activator Signaling Pathway Fibrinolysis Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways			Post-translational protein modification Attachment of GPI anchor to uPAR Dissolution of Fibrin Clot Post-translational modification: synthesis of GPI-anchored proteins
Drugs			Alteplase Urokinase Reteplase Anistreplase Tenecteplase
Diseases
GWAS
Protein-Protein Interactions		2 interactors: DPP4 PLAUR	20 interactors: EEF1A1 ELAVL1 FAP FYN HCK IGF2R IL6ST ITGAM ITGB1 JAK1 KNG1 LRP1 LRP1B MMP12 PFN2 PLAU SRPX2 SURF2 TYK2 VTN
Entrez ID		2191	5329
HPRD ID		02674	01421
Ensembl ID		ENSG00000078098	ENSG00000011422
Uniprot IDs		B4DLR2 Q12884	M0R1I2 Q03405
PDB IDs		1Z68	1YWH 2FD6 2I9B 3BT1 3BT2 3U73 3U74
Enriched GO Terms of Interacting Partners?		Urokinase Plasminogen Activator Signaling Pathway Negative Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Extracellular Matrix Organization Regulation Of Cell-cell Adhesion Mediated By Integrin Attachment Of GPI Anchor To Protein C-terminal Protein Lipidation Fibrinolysis Regulation Of Extracellular Matrix Disassembly Locomotion Regulation Of Extracellular Matrix Organization Regulation Of Cell Adhesion Mediated By Integrin Movement Of Cell Or Subcellular Component Negative Regulation Of Blood Coagulation GPI Anchor Biosynthetic Process Negative Regulation Of Coagulation GPI Anchor Metabolic Process Negative Regulation Of Wound Healing T Cell Costimulation Endothelial Cell Migration Glycolipid Biosynthetic Process Regulation Of Blood Coagulation Epithelial Cell Migration Epithelium Migration Protein Lipidation Lipoprotein Biosynthetic Process Phosphatidylinositol Biosynthetic Process Regulation Of Wound Healing Glycolipid Metabolic Process	Cell Motility Cell Migration Locomotion Peptidyl-tyrosine Autophosphorylation Movement Of Cell Or Subcellular Component Regulation Of Immune Response Regulation Of Cell Proliferation Regulation Of Collagen Catabolic Process Peptidyl-tyrosine Phosphorylation Regulation Of Immune System Process Regulation Of Cell Migration Regulation Of Smooth Muscle Cell Migration Defense Response Wound Healing Regulation Of Cell Adhesion Regulation Of Cell Motility Developmental Process Endocytosis Regulation Of Apoptotic Process Negative Regulation Of Blood Coagulation Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Wounding Negative Regulation Of Coagulation Regulation Of Cell Death Blood Coagulation Hemostasis Protein Autophosphorylation Negative Regulation Of Wound Healing Cell Adhesion Leukocyte Migration Innate Immune Response Regulation Of Innate Immune Response Cell Adhesion Mediated By Integrin Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Blood Coagulation Regulation Of Cellular Component Organization Regulation Of Body Fluid Levels Vesicle-mediated Transport Activated T Cell Proliferation Integrin-mediated Signaling Pathway Regulation Of Wound Healing Response To Stress Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Receptor-mediated Endocytosis Regulation Of Cellular Process Regulation Of Defense Response To Virus By Virus Positive Regulation Of Cell Adhesion Extracellular Matrix Organization
Tagcloud ?		adenomatous carriers decline distress emotions experience familial formerly hboc hd hereditary huntington inclined learned marginally noncarriers paradigm polyposis predictive psychological qualitative sharp steady tended testing trend unchanged undertaken ward	alters ap attributed cascade chemo chief designating erk1 fos fra govern isoform mapk microrna mir mirna multifaceted next oncogenic serpine1 shortening singular snail thousands transcriptome transcriptomes tumorigenesis utrs zeb1
Tagcloud (Difference) ?		adenomatous carriers decline distress emotions experience familial formerly hboc hd hereditary huntington inclined learned marginally noncarriers paradigm polyposis predictive psychological qualitative sharp steady tended testing trend unchanged undertaken ward	alters ap attributed cascade chemo chief designating erk1 fos fra govern isoform mapk microrna mir mirna multifaceted next oncogenic serpine1 shortening singular snail thousands transcriptome transcriptomes tumorigenesis utrs zeb1
Tagcloud (Intersection) ?