FAP

Name	fibroblast activation protein alpha
Structure
Novel Interactors	2 novel interactors: EPC2 NR4A2
Interactors	2 interactors: DPP4 PLAUR
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Focal Adhesion Cell Surface Membrane Lamellipodium Lamellipodium Membrane Ruffle Membrane Cell Projection Apical Part Of Cell Basal Part Of Cell Anchoring Junction Peptidase Complex
	Molecular Function	Protease Binding Endopeptidase Activity Serine-type Endopeptidase Activity Integrin Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Dipeptidyl-peptidase Activity Hydrolase Activity Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Angiogenesis Proteolysis Apoptotic Process Cell Adhesion Regulation Of Collagen Catabolic Process Negative Regulation Of Extracellular Matrix Disassembly Endothelial Cell Migration Proteolysis Involved In Protein Catabolic Process Regulation Of Cell Cycle Regulation Of Fibrinolysis Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Melanocyte Proliferation Positive Regulation Of Execution Phase Of Apoptosis Melanocyte Apoptotic Process Negative Regulation Of Extracellular Matrix Organization
Drugs	Sibrotuzumab
GWAS	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Coronary artery disease ( 33020668 ) Estimated glomerular filtration rate ( 30604766 ) Glomerular filtration rate ( 29403010 ) Inflammatory skin disease ( 25574825 ) Medication use (thyroid preparations) ( 31015401 ) Regular attendance at a pub or social club ( 29970889 ) Systemic lupus erythematosus ( 28714469 33272962 )
Entrez ID	2191
HPRD ID	02674
Ensembl ID	ENSG00000078098
Uniprot IDs	B4DLR2 Q12884
PDB IDs	1Z68 6Y0F 9DVQ 9DVR
GO Terms Enriched among Interactors ?	Multicellular Organismal Response To Stress Glucagon Processing General Adaptation Syndrome Urokinase Plasminogen Activator Receptor Activity Intercellular Canaliculus Positive Regulation Of Cell-cell Adhesion Adhesion Of Symbiont To Host Signaling Receptor Binding Locomotion Negative Regulation Of Extracellular Matrix Disassembly Locomotory Behavior Anchoring Junction Adhesion Of Symbiont To Host Cell Receptor-mediated Endocytosis Of Virus By Host Cell Response To Hypoxia Receptor-mediated Virion Attachment To Host Cell Negative Regulation Of Neutrophil Migration Regulation Of Cell-cell Adhesion Mediated By Integrin Response To Oxygen Levels Negative Regulation Of Neutrophil Chemotaxis Dipeptidyl-peptidase Activity Response To Decreased Oxygen Levels Psychomotor Behavior Virion Attachment To Host Cell Chemotaxis Endocytosis Involved In Viral Entry Into Host Cell Midbrain Dopaminergic Neuron Differentiation Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Habenula Development Nuclear Glucocorticoid Receptor Binding Cellular Response To Corticotropin-releasing Hormone Stimulus Dopamine Biosynthetic Process Serine-type Endopeptidase Complex Protein Complex Involved In Cell-matrix Adhesion Urokinase Plasminogen Activator Signaling Pathway Piccolo Histone Acetyltransferase Complex Locomotory Exploration Behavior Focal Adhesion Nuclear Retinoid X Receptor Binding Regulation Of Fibrinolysis Regulation Of Plasminogen Activation Catecholamine Biosynthetic Process Positive Regulation Of Homotypic Cell-cell Adhesion Extrinsic Component Of Membrane Regulation Of Dopamine Metabolic Process Positive Regulation Of Cell Adhesion Negative Regulation Of Leukocyte Chemotaxis