ALCAM and LAG3

Data Source: HiPPIP (Novel)

		ALCAM	LAG3
Name		activated leukocyte cell adhesion molecule	lymphocyte activating 3
Structure
GO Annotations	Cellular Component	Immunological Synapse Extracellular Region Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Membrane Axon Dendrite T Cell Receptor Complex Cell Projection Neuronal Cell Body Extracellular Exosome	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Identical Protein Binding	Antigen Binding Transmembrane Signaling Receptor Activity Protein Binding MHC Class II Protein Binding
	Biological Process	Adaptive Immune Response Immune System Process Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Signal Transduction Axon Guidance Motor Neuron Axon Guidance Retinal Ganglion Cell Axon Guidance Axon Extension Involved In Axon Guidance Neuron Projection Extension	Adaptive Immune Response Plasmacytoid Dendritic Cell Activation Immune System Process Cell Surface Receptor Signaling Pathway Negative Regulation Of Interleukin-2 Production T Cell Activation Natural Killer Cell Mediated Cytotoxicity Innate Immune Response Negative Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Negative Regulation Of T Cell Activation
Pathways		L1CAM interactions	MHC class II antigen presentation
Drugs		None	Relatlimab
GWAS		Adult body size ( 32376654 ) Age-related cognitive decline (memory) (slope of z-scores) ( 30954325 ) Alzheimer's disease ( 33074286 ) Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Apolipoprotein A1 levels ( 32203549 ) Blood protein levels ( 30072576 ) Body mass index ( 25673413 ) Breast cancer ( 31757997 ) Chronotype ( 30696823 ) Cortical surface area ( 32963231 ) Cortical surface area (visual PC2) ( 32198502 ) Cortical volume ( 32963231 ) Erectile dysfunction in type 1 diabetes ( 22704111 ) Glaucoma (primary open-angle) ( 33627673 ) Glomerular filtration rate in chronic kidney disease ( 26420894 ) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535 ) Initial pursuit acceleration ( 29064472 ) Intraocular pressure ( 29617998 ) Irritable mood ( 29500382 ) Metabolite levels ( 23823483 ) Ovarian disease with few adhesions ( 28333195 ) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311 ) Visceral fat ( 30942860 )	Blood protein levels ( 30072576 )
Novel Interactors		3 novel interactors: ATE1 LAG3 PIK3CA	5 novel interactors: ALCAM CLEC4D GNAI2 KCNA1 UBE2E3
Interacting Genes		3 interacting genes: ART3 CD6 EGFR	2 interacting genes: CEBPZ CPAP
Entrez ID		214	3902
HPRD ID		03389	01077
Ensembl ID		ENSG00000170017	ENSG00000089692
Uniprot IDs		B3KNN9 Q13740	P18627
PDB IDs		5A2F	7TZG 7TZH 7UM3 8SO3 8SR0 9BF9
GO Terms Enriched among Interactors		Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction ERBB Signaling Pathway Positive Regulation Of Protein Localization To Membrane Multivesicular Body, Internal Vesicle Lumen Epidermal Growth Factor Receptor Signaling Pathway Arginyl-tRNA--protein Transferase Activity Cell Surface Response To Amino Acid Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Shc-EGFR Complex Response To Butyrate Cellular Response To Hydrostatic Pressure Protein Arginylation NAD+-protein-arginine ADP-ribosyltransferase Activity Transferase Activity Extracellular Region Positive Regulation Of Cell Population Proliferation Cell Surface Receptor Signaling Pathway Response To Lipid Lipoteichoic Acid Binding Regulation Of Protein Kinase C Signaling Transmembrane Signaling Receptor Activity Epidermal Growth Factor Binding ERBB2-EGFR Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Protein Localization To Membrane Plasmacytoid Dendritic Cell Activation Negative Regulation Of Regulatory T Cell Differentiation MHC Class II Protein Binding Autosome Genomic Imprinting Response To Muscle Inactivity Phosphatidylinositol 3-kinase Complex, Class IB Phosphatidylinositol 3-kinase Complex 1-phosphatidylinositol-4-phosphate 3-kinase Activity Negative Regulation Of Fibroblast Apoptotic Process 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Response To Hydrostatic Pressure Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway Cardiac Muscle Cell Contraction Phosphatidylinositol 3-kinase Complex, Class IA	None