CYP3A5

Description		cytochrome P450 family 3 subfamily A member 5
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Monooxygenase Activity Iron Ion Binding Protein Binding Retinoic Acid 4-hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Heme Binding Metal Ion Binding Testosterone 6-beta-hydroxylase Activity Estrogen 16-alpha-hydroxylase Activity Estrogen 2-hydroxylase Activity
	Biological Process	Lipid Hydroxylation Lipid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Estrogen Metabolic Process Alkaloid Catabolic Process Xenobiotic Catabolic Process Retinol Metabolic Process Retinoic Acid Metabolic Process Aflatoxin Metabolic Process Oxidative Demethylation
Pathways		Xenobiotics Aflatoxin activation and detoxification
Drugs		Cannabidiol Diacerein Nabiximols
Diseases
GWAS		Platelet count ( 29403010) Serum metabolite levels ( 23093944 33031748) Ticagrelor levels in individuals with acute coronary syndromes treated with ticagrelor ( 25935875) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)
Interacting Genes		3 interacting genes: ATOH8 ETV5 RDH13
Entrez ID		1577
HPRD ID		05617
Ensembl ID		ENSG00000106258
Uniprot IDs		B7Z3P6 P20815
PDB IDs		5VEU
Enriched GO Terms of Interacting Partners?		Male Germ-line Stem Cell Asymmetric Division Response To High Light Intensity Germ-line Stem Cell Division Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Skeletal Muscle Acetylcholine-gated Channel Clustering Asymmetric Cell Division Myoblast Proliferation Positive Regulation Of Endothelial Cell Differentiation Response To Light Intensity All-trans-retinol Dehydrogenase (NADP+) Activity Sequence-specific Double-stranded DNA Binding Retinal Metabolic Process
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