ETV1 and RPS6KA5

Number of citations of the paper that reports this interaction (PubMedID 12569367)
0

Data Source:
HPRD (in vitro)

		ETV1	RPS6KA5
Description		ETS variant transcription factor 1	ribosomal protein S6 kinase A5
Image
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Histone H3S10 Kinase Activity Histone H3S28 Kinase Activity Histone H2AS1 Kinase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Axon Guidance Muscle Organ Development Mechanosensory Behavior Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Peripheral Nervous System Neuron Development	Negative Regulation Of Cytokine Production Chromatin Remodeling Regulation Of DNA-templated Transcription Protein Phosphorylation Inflammatory Response Axon Guidance Positive Regulation Of CREB Transcription Factor Activity Intracellular Signal Transduction TORC1 Signaling Post-translational Protein Modification Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1-mediated Signaling Pathway Regulation Of Postsynapse Organization
Pathways			ERK/MAPK targets CREB phosphorylation NCAM signaling for neurite out-growth Recycling pathway of L1 CD209 (DC-SIGN) signaling
Drugs
Diseases		Prostate cancer Ewing's sarcoma
GWAS		Blond vs. brown/black hair color ( 30531825) Chronotype ( 30696823) Coronary artery disease ( 29212778) Coronary atherosclerosis (time to event) ( 32589924) Extrahepatic cholangiocarcinoma ( 34315874) Height ( 28552196 31217584) Intraocular pressure ( 30591961) Lymphocyte count ( 27863252 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Post bronchodilator FEV1/FVC ratio in smoking ( 30068317) Post bronchodilator percent predicted FEV1 in smoking ( 30068317) Renal underexcretion gout ( 32238385) Triglyceride levels in HIV infection ( 33109212) Type 2 diabetes ( 30718926 32499647 24509480) Verbal declarative memory ( 25648963) White blood cell count ( 32888494)	A body shape index ( 34021172) Adult body size ( 32376654) Bitter alcoholic beverage consumption ( 31046077) Femoral neck bone mineral density ( 22504420 29499414) Fractures ( 30158200) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lumbar spine bone mineral density ( 29499414) Multiple sclerosis ( 31604244) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		20 interacting genes: ATR CCND3 EP300 ERG JUN KAT2B KCNA2 MAPK14 MAPK3 MAPK8 MAPKAPK2 NCOA2 NCOA3 NFE2L2 NSMCE2 PRKACA RPS6KA1 RPS6KA5 SPI1 UBE2I	60 interacting genes: ACTG1 AKT1S1 ALG8 APP ATF1 ATF2 BAD CEBPB CREB1 CREBBP CRMP1 CRYAA CTNNA3 DDAH2 DNAJC11 EIF4EBP1 EP300 ERH ETV1 EZH2 FN1 GPRASP2 H1-1 H1-5 H2AC25 H2BC21 H2BC26 H2BC3 H3-4 H3C14 H3C6 H4C14 H4C16 HMGN1 HSPB2 IL17RB ITSN1 MAP3K20 MAPK11 MAPK14 MAPT MBP MDFIC NR4A1 PDLIM1 PLA2G4A RAI1 RELA RNF19A ROBO2 RPA1 SMAD6 SMARCB1 STAT1 STAT3 STK11 TH TXNDC11 UNC119 ZNF775
Entrez ID		2115	9252
HPRD ID		02765	06789
Ensembl ID		ENSG00000006468	ENSG00000100784
Uniprot IDs		B5MCT2 B7Z2C9 P50549	O75582
PDB IDs		4AVP 4BNC 5ILS	1VZO 3KN5 3KN6 7UP4 7UP5 7UP6 7UP7 7UP8
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Protein Serine Kinase Activity Positive Regulation Of Macromolecule Biosynthetic Process Transferase Activity Regulation Of Macromolecule Metabolic Process Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Protein Serine/threonine Kinase Activity TORC1 Signaling Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription TOR Signaling Positive Regulation Of Macromolecule Metabolic Process Protein Kinase Activity Nucleus Negative Regulation Of Metabolic Process Regulation Of Gene Expression Kinase Activity Response To Hormone Regulation Of Multicellular Organismal Process Cellular Response To Stress Signal Transduction Cellular Response To Nutrient Levels Protein Modification Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cellular Response To Heat Response To Nutrient Levels MAP Kinase Activity Cellular Senescence Negative Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Component Organization Protein Phosphorylation Positive Regulation Of Cyclase Activity Protein Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Stress-activated MAPK Cascade Response To Mechanical Stimulus	Structural Constituent Of Chromatin Nucleosome Nucleosome Organization Chromatin Organization DNA Binding Response To Light Stimulus Protein Heterodimerization Activity Response To UV Response To UV-B Nucleosome Assembly Nucleus Chromatin Remodeling Protein-containing Complex Assembly Chromatin DNA Binding Protein-containing Complex Organization Protein-DNA Complex Assembly Regulation Of Cell Development Response To Radiation Chromatin Cellular Response To UV Positive Regulation Of Cell Differentiation Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Light Stimulus Regulation Of Macromolecule Metabolic Process Cellular Response To UV-B Regulation Of Cell Differentiation Transcription Regulator Complex Regulation Of Hemopoiesis Positive Regulation Of Biosynthetic Process Nucleoplasm Double-stranded DNA Binding Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Response To Stress Positive Regulation Of Multicellular Organismal Process Sequence-specific DNA Binding Chromosome Cellular Component Assembly Chromatin Binding Regulation Of Developmental Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Multicellular Organismal Development Regulation Of Myeloid Cell Differentiation Transcription Coactivator Binding Intracellular Signaling Cassette Positive Regulation Of Cytokine Production Intracellular Signal Transduction
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