ETF1 and MYOZ2

		ETF1	MYOZ2
Description		eukaryotic translation termination factor 1	myozenin 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Translation Release Factor Complex Cytosolic Ribosome	Cytoplasm Actin Cytoskeleton Sarcomere Z Disc
	Molecular Function	RNA Binding Translation Release Factor Activity Peptidyl-tRNA Hydrolase Activity Protein Binding Translation Termination Factor Activity Translation Release Factor Activity, Codon Specific Ribosome Binding Sequence-specific MRNA Binding	Actin Binding Protein Binding Protein Phosphatase 2B Binding Telethonin Binding FATZ Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytoplasmic Translational Termination Translation Translational Termination Regulation Of Translational Termination Protein Methylation Ribosome Disassembly	Negative Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Tissue Development Skeletal Muscle Fiber Adaptation Sarcomere Organization Negative Regulation Of Calcineurin-NFAT Signaling Cascade
Pathways		Eukaryotic Translation Termination Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Protein hydroxylation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28552196) California verbal learning test score ( 31596458) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) General risk tolerance (MTAG) ( 30643258) Schizophrenia ( 25056061 28991256 29483656 30285260)	HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 32888494) PR interval ( 32439900) Refractive error ( 32231278)
Interacting Genes		8 interacting genes: CEBPA GSPT1 GSPT2 KEAP1 LIG4 OGT PPP2CA UBC	18 interacting genes: ACTN1 ACTN2 ACTN4 CRK DRICH1 EWSR1 FLNC HSPB2 LDB3 MBLAC1 MKRN3 MYB PDLIM3 PPP3CA PPP3CB RBPMS WWOX ZDHHC17
Entrez ID		2107	51778
HPRD ID		02616	05724
Ensembl ID		ENSG00000120705	ENSG00000172399
Uniprot IDs		B7Z7P8 P62495	Q9NPC6
PDB IDs		1DT9 2HST 2KTU 2KTV 2LGT 2LLX 2MQ6 2MQ9 3E1Y 3J5Y 3JAG 3JAH 3JAI 4D5N 4D61 5A8L 5LZT 5LZU 5LZV 6D90 6IP8 6XA1 6ZME 8SCB
Enriched GO Terms of Interacting Partners?		Translation Release Factor Complex Translation Release Factor Activity Stem Cell Proliferation Translational Termination Cellular Response To Lithium Ion Macromolecule Catabolic Process Response To Lithium Ion Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Embryonic Placenta Development Macromolecule Metabolic Process In Utero Embryonic Development Positive Regulation Of Proteolysis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Granulocyte Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Macrophage Differentiation Negative Regulation Of Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Biosynthetic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Macromolecule Biosynthetic Process Response To Fluid Shear Stress Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Protein Modification Process Catabolic Process RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Establishment Of Integrated Proviral Latency Regulation Of Glycolytic Process RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Granzyme-mediated Apoptotic Signaling Pathway Chordate Embryonic Development Multicellular Organism Development Embryo Development Ending In Birth Or Egg Hatching Regulation Of Carbohydrate Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Response To Vitamin B2 C/EBP Complex Establishment Of Viral Latency Regulation Of ATP Metabolic Process RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Cell Population Proliferation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Mononuclear Cell Differentiation Response To Metal Ion Regulation Of Purine Nucleotide Metabolic Process	Z Disc Cytoskeletal Protein Binding Muscle Cell Development Pseudopodium Actin Cytoskeleton Organization Actin Filament-based Process Actin Binding Cell Development Stress Fiber Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Transcription Coactivator Activity Actin Cytoskeleton Sarcomere Organization Calmodulin-dependent Protein Phosphatase Activity Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Cortical Actin Cytoskeleton Identical Protein Binding Positive Regulation Of Monoatomic Ion Transport Protein Serine/threonine Phosphatase Complex Platelet Alpha Granule Lumen Postsynaptic Actin Cytoskeleton Positive Regulation Of Calcium Ion Import Across Plasma Membrane Cytoskeleton Organization Enzyme Binding Actin Filament Binding Striated Muscle Cell Development Negative Regulation Of Calcium Ion Import Regulation Of Calcium Ion Import Across Plasma Membrane Muscle Alpha-actinin Binding Regulation Of Monoatomic Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transport Positive Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Calcineurin-NFAT Signaling Cascade Actomyosin Structure Organization Regulation Of Monoatomic Ion Transmembrane Transport Glutamatergic Synapse Positive Regulation Of Calcium Ion Import Positive Regulation Of RNA Metabolic Process Focal Adhesion Assembly Calcineurin-mediated Signaling Calcium Ion Binding Skeletal Muscle Fiber Development Filamentous Actin Transmembrane Transporter Binding Muscle Structure Development Regulation Of Metal Ion Transport
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