TRIM73 and PSMF1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TRIM73	PSMF1
Description		tripartite motif containing 73	proteasome inhibitor subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Proteasome Complex Cytoplasm Endoplasmic Reticulum Cytosol Proteasome Core Complex Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Zinc Ion Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Endopeptidase Inhibitor Activity Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Proteasome Binding
	Biological Process	Innate Immune Response	Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process
Pathways			Proteasome assembly
Drugs
Diseases
GWAS			Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Logical memory (immediate recall) in Alzheimer's disease dementia ( 29274321) Neonatal white matter microstructure ( 33009551)
Interacting Genes		18 interacting genes: ARID5A BEX2 C9orf72 DDIT4L FHL2 GNG3 HGS KRT34 NTAQ1 OIP5 PNMA1 POU6F2 PRR35 PSMF1 RUSC1 TASOR2 TTC23 YPEL3	35 interacting genes: BEND7 CCDC85B CD2BP2 CRX CTBP2 DVL2 DVL3 GATA1 HOOK2 IKZF3 KHDRBS2 KHDRBS3 LDOC1 LNX1 LNX2 MAGEA11 MAGED1 MIEF2 NUDT21 PAK5 PDLIM7 QKI RAB33A RALYL RBFOX1 RBFOX2 RBMX RBPMS RHOXF2 RNF126 TENT5B TLE5 TRAF2 TRIM73 WWP2
Entrez ID		375593	9491
HPRD ID		18606	17919
Ensembl ID		ENSG00000178809	ENSG00000125818
Uniprot IDs		Q86UV7	A0A140VJT2 B4DXW9 Q5QPM7 Q92530
PDB IDs			2VT8 4OUH
Enriched GO Terms of Interacting Partners?			Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process MRNA Binding Regulation Of RNA Splicing Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Identical Protein Binding MRNA Processing Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression Nucleic Acid Binding Regulation Of Macromolecule Biosynthetic Process MRNA Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleus RNA Processing Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of MRNA Metabolic Process Positive Regulation Of Neuron Projection Arborization Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process RNA Metabolic Process MRNA Stabilization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Neuron Projection Arborization Protein K63-linked Ubiquitination Negative Regulation Of MRNA Catabolic Process RNA Stabilization Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Ubiquitin Protein Ligase Activity RNA Splicing Nucleoplasm Cytoplasmic Stress Granule Negative Regulation Of RNA Catabolic Process SH3 Domain Binding Nucleic Acid Metabolic Process Ubiquitin-protein Transferase Activity Positive Regulation Of Metabolic Process TORC2 Complex Disassembly Internal N(7)-methylguanine-containing RNA Reader Activity Positive Regulation Of Pro-B Cell Differentiation
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