POP7

Description		POP7 ribonuclease P/MRP subunit
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GO Annotations	Cellular Component	Ribonuclease MRP Complex Nucleus Nucleoplasm Nucleolar Ribonuclease P Complex Nucleolus Cytoplasm Multimeric Ribonuclease P Complex
	Molecular Function	Nucleic Acid Binding RNA Binding Ribonuclease P Activity Protein Binding Ribonuclease P RNA Binding
	Biological Process	TRNA 5'-leader Removal RRNA Processing RNA Processing TRNA Processing
Pathways		tRNA processing in the nucleus
Drugs
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Low density lipoprotein cholesterol levels ( 32154731) Medication use (thyroid preparations) ( 31015401) Pursuit maintenance gain in psychotic disorders ( 29064472) Red blood cell count ( 27863252 32888494) Schizophrenia ( 30285260)
Interacting Genes		11 interacting genes: AKT1 APP C9orf72 FOXP1 HSPB1 LAGE3 RPP25 RPP25L RPP38 RPP40 SMN1
Entrez ID		10248
HPRD ID		09357
Ensembl ID		ENSG00000172336
Uniprot IDs		O75817
PDB IDs		6AHR 6AHU 6CWX 6LT7
Enriched GO Terms of Interacting Partners?		Ribonuclease MRP Complex TRNA Processing TRNA 5'-leader Removal TRNA 5'-end Processing TRNA Metabolic Process Ribonuclease P RNA Binding Multimeric Ribonuclease P Complex Ribonuclease P Activity RNA Processing Main Axon RNA Metabolic Process Nucleolar Ribonuclease P Complex Nucleus Regulation Of Interleukin-1 Beta Production Positive Regulation Of Endothelial Cell Migration Regulation Of Interleukin-1 Production Nucleic Acid Metabolic Process Perikaryon Cellular Response To Vascular Endothelial Growth Factor Stimulus RNA Binding Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Endothelial Cell Migration Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Nitric Oxide Metabolic Process RRNA Processing Regulation Of Phosphorus Metabolic Process Postsynapse Response To Nerve Growth Factor Positive Regulation Of Cell Motility Cellular Response To Nerve Growth Factor Stimulus Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Locomotion RRNA Metabolic Process Cellular Response To Growth Factor Stimulus Regulation Of TRNA Methylation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Protein Kinase C Signaling Ribonuclease MRP Activity Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Interleukin-1 Beta Production Macrophage Activation
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