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CTNNBIP1 and CTNNB1
Number of citations of the paper that reports this interaction (PMID
10898789
)
84
Data Source:
HPRD
(in vitro, in vivo, two hybrid)
CTNNBIP1
CTNNB1
Gene Name
catenin, beta interacting protein 1
catenin (cadherin-associated protein), beta 1, 88kDa
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Beta-catenin Destruction Complex
Spindle Pole
Nucleus
Nucleoplasm
Transcription Factor Complex
Nuclear Euchromatin
Cytoplasm
Centrosome
Cytosol
Plasma Membrane
Cell-cell Junction
Adherens Junction
Cell-cell Adherens Junction
Fascia Adherens
Tight Junction
Focal Adhesion
Cell Cortex
Membrane
Basolateral Plasma Membrane
Lateral Plasma Membrane
Catenin Complex
Z Disc
Lamellipodium
Cell Junction
Beta-catenin Destruction Complex
Microvillus Membrane
Protein-DNA Complex
Scrib-APC-beta-catenin Complex
Dendritic Shaft
Apical Part Of Cell
Synapse
Perinuclear Region Of Cytoplasm
Extracellular Vesicular Exosome
Beta-catenin-TCF7L2 Complex
Cell Periphery
Molecular Function
Protein Binding
Beta-catenin Binding
Armadillo Repeat Domain Binding
RNA Polymerase II Activating Transcription Factor Binding
Double-stranded DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Transcription Coactivator Activity
Signal Transducer Activity
Protein Binding
Protein C-terminus Binding
Transcription Factor Binding
Enzyme Binding
Kinase Binding
Protein Phosphatase Binding
Estrogen Receptor Binding
Protein Complex Binding
Ionotropic Glutamate Receptor Binding
Nuclear Hormone Receptor Binding
Transcription Regulatory Region DNA Binding
Ion Channel Binding
Alpha-catenin Binding
Cadherin Binding
SMAD Binding
Androgen Receptor Binding
Nitric-oxide Synthase Binding
I-SMAD Binding
R-SMAD Binding
Repressing Transcription Factor Binding
Euchromatin Binding
Biological Process
Branching Involved In Ureteric Bud Morphogenesis
Regulation Of Vascular Permeability Involved In Acute Inflammatory Response
Anterior/posterior Pattern Specification
Wnt Signaling Pathway
Negative Regulation Of Wnt Signaling Pathway
Negative Regulation Of Protein Binding
Negative Regulation Of DNA Binding
Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of Monocyte Differentiation
Positive Regulation Of Osteoblast Differentiation
Negative Regulation Of Smooth Muscle Cell Proliferation
Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter
Negative Regulation Of Mesenchymal Cell Proliferation
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Embryonic Axis Specification
Patterning Of Blood Vessels
Branching Involved In Ureteric Bud Morphogenesis
In Utero Embryonic Development
Gastrulation With Mouth Forming Second
Cell Fate Specification
Endodermal Cell Fate Commitment
Neuron Migration
Epithelial To Mesenchymal Transition
Neural Plate Development
Liver Development
Positive Regulation Of Neuroblast Proliferation
Positive Regulation Of Mesenchymal Cell Proliferation
Lens Morphogenesis In Camera-type Eye
Regulation Of Secondary Heart Field Cardioblast Proliferation
Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis
Transcription, DNA-templated
Apoptotic Process
Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Cell Adhesion
Cell-matrix Adhesion
Ectoderm Development
Glial Cell Fate Determination
Midgut Development
Negative Regulation Of Cell Proliferation
Anterior/posterior Axis Specification
Dorsal/ventral Axis Specification
Proximal/distal Pattern Formation
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process
Schwann Cell Proliferation
Wnt Signaling Pathway
Single Organismal Cell-cell Adhesion
Stem Cell Maintenance
Layer Formation In Cerebral Cortex
Central Nervous System Vasculogenesis
Osteoclast Differentiation
Androgen Receptor Signaling Pathway
Male Genitalia Development
Regulation Of Centriole-centriole Cohesion
Pancreas Development
Hair Follicle Morphogenesis
Regulation Of Myelination
Negative Regulation Of Chondrocyte Differentiation
Response To Estradiol
Positive Regulation Of Type I Interferon Production
T Cell Differentiation In Thymus
Negative Regulation Of Protein Sumoylation
Response To Cytokine
Adherens Junction Assembly
Protein Localization To Cell Surface
Embryonic Heart Tube Development
Genitalia Morphogenesis
Embryonic Forelimb Morphogenesis
Embryonic Hindlimb Morphogenesis
Hair Cell Differentiation
Embryonic Skeletal Limb Joint Morphogenesis
Regulation Of T Cell Proliferation
Odontogenesis Of Dentin-containing Tooth
Response To Drug
Regulation Of Cell Fate Specification
Muscle Cell Differentiation
Embryonic Digit Morphogenesis
Positive Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of MAPK Cascade
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition
Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process
Innate Immune Response
Myoblast Differentiation
Bone Resorption
Positive Regulation Of Endothelial Cell Differentiation
Positive Regulation Of Osteoblast Differentiation
Negative Regulation Of Osteoclast Differentiation
Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Regulation Of Angiogenesis
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Mitotic Cell Cycle, Embryonic
Response To Cadmium Ion
Regulation Of Fibroblast Proliferation
Cell Maturation
Synaptic Vesicle Transport
Thymus Development
Oocyte Development
Embryonic Foregut Morphogenesis
Regulation Of Smooth Muscle Cell Proliferation
Negative Regulation Of Oligodendrocyte Differentiation
Synapse Organization
Smooth Muscle Cell Differentiation
Positive Regulation Of Muscle Cell Differentiation
Protein Heterooligomerization
Positive Regulation Of Histone H3-K4 Methylation
Oviduct Development
Canonical Wnt Signaling Pathway
Trachea Formation
Epithelial Tube Branching Involved In Lung Morphogenesis
Lung Cell Differentiation
Lung-associated Mesenchyme Development
Lung Induction
Epithelial Cell Differentiation Involved In Prostate Gland Development
Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Hair Follicle Placode Formation
Mesenchymal Cell Proliferation Involved In Lung Development
Endothelial Tube Morphogenesis
Fungiform Papilla Formation
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation
Sympathetic Ganglion Development
Regulation Of Centromeric Sister Chromatid Cohesion
Cellular Response To Mechanical Stimulus
Cellular Response To Growth Factor Stimulus
Cellular Response To Indole-3-methanol
Renal Vesicle Formation
Renal Inner Medulla Development
Renal Outer Medulla Development
Nephron Tubule Formation
Regulation Of Nephron Tubule Epithelial Cell Differentiation
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Calcium Ion Import
Negative Regulation Of Neuron Death
Cellular Response To Insulin-like Growth Factor Stimulus
Regulation Of Protein Localization To Cell Surface
Positive Regulation Of Determination Of Dorsal Identity
Positive Regulation Of DNA-templated Transcription, Initiation
Negative Regulation Of Apoptotic Signaling Pathway
Pathways
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TCF dependent signaling in response to WNT
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
Signaling by Wnt
Signaling by WNT in cancer
deactivation of the beta-catenin transactivating complex
APC truncation mutants have impaired AXIN binding
misspliced GSK3beta mutants stabilize beta-catenin
T41 mutants of beta-catenin aren't phosphorylated
TCF7L2 mutants don't bind CTBP
truncated APC mutants destabilize the destruction complex
Signaling by Wnt
binding of TCF/LEF:CTNNB1 to target gene promoters
deactivation of the beta-catenin transactivating complex
APC truncation mutants are not K63 polyubiquitinated
disassembly of the destruction complex and recruitment of AXIN to the membrane
S37 mutants of beta-catenin aren't phosphorylated
Degradation of beta-catenin by the destruction complex
AXIN mutants destabilize the destruction complex, activating WNT signaling
RNF mutants show enhanced WNT signaling and proliferation
S33 mutants of beta-catenin aren't phosphorylated
XAV939 inhibits tankyrase, stabilizing AXIN
Innate Immune System
truncations of AMER1 destabilize the destruction complex
CDO in myogenesis
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Cytosolic sensors of pathogen-associated DNA
formation of the beta-catenin:TCF transactivating complex
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
AXIN missense mutants destabilize the destruction complex
S45 mutants of beta-catenin aren't phosphorylated
repression of WNT target genes
beta-catenin independent WNT signaling
deletions in the AMER1 gene destabilize the destruction complex
Ca2+ pathway
Myogenesis
AMER1 mutants destabilize the destruction complex
TCF dependent signaling in response to WNT
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Signaling by WNT in cancer
Drugs
Urea
Diseases
GWAS
Bone mineral density (
22504420
)
Bone mineral density (hip) (
19801982
)
Protein-Protein Interactions
11 interactors:
BEND5
CTNNA2
CTNNB1
EMD
INCA1
JUP
KRTAP10-3
KRTAP10-7
REL
TCF7L2
USHBP1
172 interactors:
ACP1
AJAP1
AKT1
AMER1
APC
APC2
APP
AR
ARHGAP32
ASH2L
AXIN1
AXIN2
BCL3
BCL9
BCL9L
BOC
BRCA1
BTRC
CA9
CARM1
CASP3
CASP8
CBL
CBY1
CCND1
CDC27
CDC73
CDH1
CDH11
CDH15
CDH16
CDH2
CDH24
CDH3
CDH5
CDH7
CDH8
CDH9
CDK2
CDK5R1
CDK6
CDON
CEBPA
CHD8
CHUK
CREBBP
CSNK1A1
CSNK1D
CSNK2A1
CSNK2B
CTNNA1
CTNNA3
CTNNBIP1
CTNND2
DLG5
DSC3
DVL1
DVL3
EGFR
ELAVL1
EP300
ERBB2
ERBB2IP
ESR1
EZR
FER
FHIT
FHL2
FLT1
FOXO1
FOXO4
FSCN1
FUS
FYN
GLIS2
GNA13
GRIK2
GRIN1
GRIN2D
GSK3B
HDAC6
HIF1A
HIST1H1C
HNF1A
IGF2BP1
IKBKB
IQGAP1
JADE1
KAT2A
KAT2B
KDR
KMT2A
KMT2D
LATS2
LEF1
LEO1
MAGI1
MAGI2
MAPK8
MAPK9
MEN1
MET
MITF
MUC1
NCOA2
NDRG1
NEK2
NEURL2
NF2
NFKB1
NOTCH1
NR5A1
PECAM1
PICK1
PIK3R1
PIN1
PITX2
PKD1
PKP2
PLK1
PPM1A
PSEN1
PSEN2
PTGS2
PTPN1
PTPN13
PTPN14
PTPN6
PTPRF
PTPRJ
PTPRK
PTPRM
PTPRU
PTPRZ1
PYGO1
RAPGEF2
RBBP5
RBX1
RUVBL1
RUVBL2
RXRA
SALL1
SIAH1
SKP1
SLC9A3R1
SMAD2
SMAD3
SMAD4
SMAD7
SMARCA4
SMARCA5
SOX1
SOX17
SPN
SRC
TAX1BP3
TBL1X
TCF3
TCF4
TCF7L1
TCF7L2
TFAP2A
TGFBR1
TGFBR2
TLE1
TRIP10
TRRAP
UBE2B
UBE2D1
UHRF2
USP9X
ZFYVE9
Entrez ID
56998
1499
HPRD ID
09677
00286
Ensembl ID
ENSG00000178585
ENSG00000168036
Uniprot IDs
Q9NSA3
P35222
PDB IDs
1LUJ
1M1E
1T08
1G3J
1JDH
1JPW
1LUJ
1P22
1QZ7
1T08
1TH1
2G57
2GL7
2Z6H
3DIW
3FQN
3FQR
3SL9
3SLA
3TX7
4DJS
Enriched GO Terms of Interacting Partners
?
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process
Regulation Of Canonical Wnt Signaling Pathway
Cellular Response To Indole-3-methanol
Regulation Of Wnt Signaling Pathway
Positive Regulation Of Nucleocytoplasmic Transport
Muscle Structure Development
Positive Regulation Of Glycoprotein Biosynthetic Process
Positive Regulation Of Protein Export From Nucleus
Genitalia Morphogenesis
Positive Regulation Of Signal Transduction
Positive Regulation Of Glycoprotein Metabolic Process
Positive Regulation Of Intracellular Protein Transport
Regulation Of Cell Fate Specification
Regulation Of Signal Transduction
Regulation Of Cell Proliferation
Regulation Of Nucleocytoplasmic Transport
Skin Development
Regulation Of Glycoprotein Biosynthetic Process
Regulation Of Signaling
Positive Regulation Of Intracellular Transport
Regulation Of Protein Export From Nucleus
Regulation Of Protein Localization
Regulation Of Cell Fate Commitment
Positive Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Intracellular Protein Transport
Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Epithelial Cell-cell Adhesion
Regulation Of Oligodendrocyte Differentiation
Myoblast Differentiation
Adherens Junction Assembly
Muscle Cell Differentiation
Regulation Of Myelination
Positive Regulation Of Protein Transport
Positive Regulation Of Stem Cell Differentiation
Genitalia Development
Regulation Of Cellular Localization
Regulation Of Epithelial To Mesenchymal Transition
Digestive Tract Morphogenesis
Regulation Of Glial Cell Differentiation
Regulation Of Intracellular Transport
Negative Regulation Of Cell Cycle
Adherens Junction Organization
Response To Organic Substance
Canonical Wnt Signaling Pathway
Positive Regulation Of Muscle Cell Differentiation
Pancreas Development
Single Organismal Cell-cell Adhesion
Regulation Of Fibroblast Proliferation
Regulation Of Gliogenesis
Positive Regulation Of Cellular Metabolic Process
Regulation Of Signal Transduction
Positive Regulation Of Metabolic Process
Regulation Of Signaling
Cell Surface Receptor Signaling Pathway
Cellular Response To Stimulus
Positive Regulation Of Gene Expression
Signaling
Cell Communication
Signal Transduction
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Biosynthetic Process
Anatomical Structure Development
Multicellular Organismal Development
Regulation Of Metabolic Process
Response To Stimulus
Developmental Process
Negative Regulation Of Signaling
Wnt Signaling Pathway
Anatomical Structure Morphogenesis
Cell Differentiation
Negative Regulation Of Signal Transduction
System Development
Regulation Of Cell Proliferation
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Gene Expression
Organ Development
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Tissue Development
Negative Regulation Of Cellular Metabolic Process
Cell Development
Regulation Of Wnt Signaling Pathway
Regulation Of Cell Differentiation
Regulation Of Cellular Process
Regulation Of Nitrogen Compound Metabolic Process
Response To Organic Substance
Regulation Of Protein Metabolic Process
Cellular Protein Modification Process
Regulation Of Cellular Protein Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Epithelium Development
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Signal Transduction
Regulation Of RNA Metabolic Process
Cellular Response To Organic Substance
Negative Regulation Of Biosynthetic Process
Enzyme Linked Receptor Protein Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Tagcloud
?
acc
acquires
adrenal
adrenocortical
altering
came
centripetal
compr
cortex
detail
examining
exome
gland
igf2
landscape
medulla
mutational
opening
perspectives
physiol
played
prognostication
progress
steroidogenic
subcapsular
summarizes
tracing
zonation
zones
Tagcloud (Difference)
?
acc
acquires
adrenal
adrenocortical
altering
came
centripetal
compr
cortex
detail
examining
exome
gland
igf2
landscape
medulla
mutational
opening
perspectives
physiol
played
prognostication
progress
steroidogenic
subcapsular
summarizes
tracing
zonation
zones
Tagcloud (Intersection)
?