C4orf46 and HUS1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		C4orf46	HUS1
Description		chromosome 4 open reading frame 46	HUS1 checkpoint clamp component
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Checkpoint Clamp Complex Site Of Double-strand Break
	Molecular Function	Protein Binding	Protein Binding
	Biological Process		DNA Damage Checkpoint Signaling Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Repair Nucleotide-excision Repair DNA Damage Response Response To Radiation Response To UV Embryo Development Ending In Birth Or Egg Hatching Mitotic Intra-S DNA Damage Checkpoint Signaling Mitotic DNA Replication Checkpoint Signaling Meiotic DNA Integrity Checkpoint Signaling Cellular Response To Ionizing Radiation
Pathways			Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
Drugs
Diseases
GWAS			Gut microbiota alpha diversity (Shannon index) ( 33208821) Obstructive sleep apnea during REM sleep (apnea hypopnea index) ( 29077507)
Interacting Genes		10 interacting genes: APP BLOC1S6 CDR2 CDR2L HSF2BP HUS1 KXD1 PICK1 SRPK2 TFPT	28 interacting genes: C4orf46 CD200 DCUN1D5 DNAJC7 FEN1 GRIP1 HDAC1 HUS1B MSH2 MSH3 MSH6 NEIL1 NTAQ1 OGG1 PCNA POLB RAD1 RAD17 RAD9A RAD9B RHNO1 RPA1 RPA2 SDCBP SIRT6 TDG TOPBP1 YWHAQ
Entrez ID		201725	3364
HPRD ID		17319	04787
Ensembl ID		ENSG00000205208	ENSG00000136273
Uniprot IDs		Q504U0	A4D2F2 O60921
PDB IDs			3A1J 3G65 3GGR 6J8Y 7Z6H 8GNN 8WU8
Enriched GO Terms of Interacting Partners?		Cytoskeleton-dependent Intracellular Transport Transport Along Microtubule Microtubule-based Transport Organelle Transport Along Microtubule BLOC-1 Complex Microtubule-based Movement Positive Regulation Of Receptor Internalization Amyloid-beta Complex Presynapse Growth Cone Lamellipodium Neuron Projection Organization Intracellular Transport Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Receptor-mediated Endocytosis Bradykinin Biosynthetic Process Vesicle Cytoskeletal Trafficking Vesicle Transport Along Microtubule Establishment Of Organelle Localization Circadian Sleep/wake Cycle Glial Cell Development Positive Regulation Of Neuron Apoptotic Process G Protein-coupled Receptor Binding Microtubule-based Process Regulation Of Receptor Internalization Axo-dendritic Transport Cellular Localization Establishment Of Localization In Cell Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Meiotic DNA Integrity Checkpoint Signaling PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Telomere Maintenance Intracellular Nitric Oxide Homeostasis Establishment Of Vesicle Localization Golgi To Secretory Granule Transport Trans-Golgi Network Membrane Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus	DNA Repair Damaged DNA Binding DNA Damage Response DNA Metabolic Process Base-excision Repair Cellular Response To Stress DNA Damage Checkpoint Signaling Response To Radiation Signal Transduction In Response To DNA Damage DNA Recombination Nucleic Acid Metabolic Process Mismatch Repair Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Checkpoint Clamp Complex Mitotic Intra-S DNA Damage Checkpoint Signaling Double-strand Break Repair Negative Regulation Of Cell Cycle Phase Transition DNA Replication Checkpoint Signaling Site Of Double-strand Break Oxidized Purine DNA Binding Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Process Protein Localization To Site Of Double-strand Break Response To Stress Mismatched DNA Binding Chromosome Organization Response To Ionizing Radiation Negative Regulation Of Cell Cycle Single Guanine Insertion Binding Dinucleotide Insertion Or Deletion Binding Base-excision Repair, Gap-filling Nucleoplasm Chromosome, Telomeric Region Guanine/thymine Mispair Binding Intracellular Signal Transduction Chromatin-protein Adaptor Activity Protein Localization To Chromosome Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Macromolecule Metabolic Process Recombinational Repair Regulation Of Cell Cycle Process Maintenance Of DNA Repeat Elements MutLalpha Complex Binding Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Response To UV Nucleus Enzyme Binding Depyrimidination
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