EMX1 and ALX4

Number of citations: 41 (PubMedID 20211142)
Data Source: BioGRID (two hybrid)

		EMX1	ALX4
Name		empty spiracles homeobox 1	ALX homeobox 4
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Chromosome Nucleolus Cytoplasm	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	In Utero Embryonic Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Brain Development Response To Xenobiotic Stimulus Post-embryonic Development Telencephalon Development Cerebral Cortex Regionalization Cerebral Cortex Neuron Differentiation Cerebral Cortex Development Neuron Differentiation Brain Morphogenesis Homeostasis Of Number Of Cells Radial Glial Cell Differentiation Neuroepithelial Cell Differentiation Regulation Of Oligodendrocyte Progenitor Proliferation Neuron Projection Extension	Skeletal System Development Hair Follicle Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Muscle Organ Development Post-embryonic Development Anterior/posterior Pattern Specification Limb Morphogenesis Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development Digestive Tract Development Neuron Development Embryonic Skeletal System Morphogenesis Skeletal System Morphogenesis Roof Of Mouth Development
Diseases		None	Enlarged parietal foramina/cranium bifidum Frontonasal dysplasia
GWAS		Malaria ( 31844061 ) Schizophrenia ( 28991256 30285260 )	Blood pressure measurement (high sodium intervention) ( 24165912 ) Brain morphology (MOSTest) ( 32665545 ) Cadmium levels ( 26025379 ) Excessive hairiness ( 29895819 ) ghrelin levels ( 33852427 ) Gout ( 22179738 ) Male-pattern baldness ( 27182965 29146897 ) Monobrow ( 27182965 ) Response to antidepressants in depression ( 29998114 ) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355 )
Interacting Genes		8 interacting genes: ALX4 ELK1 GTF2A1L HOXA10 LINC00839 POLR2D PRDM4 TP63	14 interacting genes: ALX1 CEBPE EMX1 FOXA3 GATA4 HOXA3 HOXB13 HOXB6 HOXD3 IQUB LEF1 PARVG SOX10 SOX2
Entrez ID		2016	60529
HPRD ID		08963	05661
Ensembl ID		ENSG00000135638	ENSG00000052850
Uniprot IDs		Q04741	Q9H161
PDB IDs		Not available	2M0C 8OSB
GO Terms Enriched among Interactors		DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Embryonic Limb Morphogenesis Transcription By RNA Polymerase II Limb Morphogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Prostate Gland Development DNA-templated Transcription Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Skeletal System Development Proximal/distal Pattern Formation Embryonic Hindlimb Morphogenesis Sequence-specific Double-stranded DNA Binding Embryonic Forelimb Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Hindlimb Morphogenesis Forelimb Morphogenesis Response To Testosterone Hair Follicle Development Gland Development Macromolecule Biosynthetic Process Regionalization Transcription Initiation At RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Nucleobase-containing Compound Biosynthetic Process Ectoderm And Mesoderm Interaction Epidermal Cell Division DNA-templated Transcription Initiation Hair Cycle Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Pattern Specification Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Embryonic Morphogenesis Chromatin RNA Polymerase Complex Positive Regulation Of Somatic Stem Cell Population Maintenance Cloacal Septation Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Sequence-specific DNA Binding Neuron Apoptotic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Hippocampal Neuron Apoptotic Process Female Genitalia Morphogenesis	Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Regulation Of Transcription By RNA Polymerase II Regionalization DNA Binding Anterior/posterior Pattern Specification Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Pattern Specification Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Anatomical Structure Morphogenesis Regulation Of RNA Metabolic Process Gland Development Regulation Of Nucleobase-containing Compound Metabolic Process Embryonic Skeletal System Morphogenesis Embryonic Morphogenesis Sequence-specific DNA Binding Transcription Cis-regulatory Region Binding Skeletal System Morphogenesis Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Morphogenesis Regulation Of Macromolecule Biosynthetic Process Embryonic Organ Morphogenesis Glossopharyngeal Nerve Morphogenesis Regulation Of Primary Metabolic Process Developmental Process Animal Organ Development Regulation Of Macromolecule Metabolic Process DNA-templated Transcription Cellular Developmental Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription Regulator Complex Positive Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Radial Glial Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Developmental Process Cranial Nerve Morphogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Glial Cell Differentiation Nucleus System Development Morphogenesis Of An Epithelium RNA Polymerase II Transcription Regulator Complex