RPL22L1 and SDCBP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RPL22L1	SDCBP2
Description		ribosomal protein L22 like 1	syndecan binding protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ribosome Ribonucleoprotein Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Nuclear Speck Extracellular Exosome
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Lipid Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Cytoplasmic Translation Translation	Nervous System Development Cell Population Proliferation Intracellular Signal Transduction Intracellular Transport
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases
GWAS			Estimated glomerular filtration rate ( 31152163) Metabolite levels ( 23823483)
Interacting Genes		2 interacting genes: PTEN SDCBP2	66 interacting genes: ADAP1 AKAP17A AP1M1 ARF4 BEND7 C1orf35 CHCHD1 CRCT1 CRY2 CT45A1 CT45A10 CT45A3 CT45A5 CTH DMC1 DPPA2 EIF1AD FAM133A FAM13C FAM9B FBXO28 GABRA3 HSBP1 LGALS14 LGALS2 LYAR MED4 NFASC NFU1 NKAPD1 NOP56 NPM2 NRXN1 NUF2 PAFAH1B3 PDCD6IP PHC1 PRM2 PRPF38A PRPF40A PRR13 PTMS RNF111 RNPS1 RPL22 RPL22L1 RPL41 SDCBP SEC23A SREK1IP1 SYT17 TCP11L1 TDO2 THAP6 TIFA TM4SF1 TNNT1 TNP1 TRAF1 VAX1 VPS25 YTHDC1 ZCCHC10 ZCCHC17 ZNF581 ZRSR2
Entrez ID		200916	27111
HPRD ID		19507	18032
Ensembl ID		ENSG00000163584	ENSG00000125775
Uniprot IDs		C9JYQ9 Q6P5R6	Q9H190
PDB IDs
Enriched GO Terms of Interacting Partners?		Locomotor Rhythm Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Cellular Response To Electrical Stimulus Lipid Binding Ubiquitin Ligase Activator Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Spindle Assembly Involved In Female Meiosis Nervous System Development Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Synaptic Vesicle Clustering Postsynaptic Specialization Assembly Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Neuron-neuron Synaptic Transmission Phosphatidylinositol Phosphate Phosphatase Activity Central Nervous System Myelin Maintenance Negative Regulation Of Cell Size Presynaptic Membrane Organization Schmidt-Lanterman Incisure Rhythmic Synaptic Transmission Anaphase-promoting Complex Binding Postsynaptic Density Assembly Forebrain Morphogenesis Negative Regulation Of Excitatory Postsynaptic Potential Presynaptic Membrane Assembly Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Phosphatidylinositol-3-phosphate Phosphatase Activity Prepulse Inhibition Meiotic Spindle Assembly Maternal Behavior Myelin Maintenance Parental Behavior Synapse Maturation Negative Regulation Of Epithelial Cell Migration Postsynaptic Density Organization Negative Regulation Of Focal Adhesion Assembly Dendritic Spine Morphogenesis Ubiquitin-specific Protease Binding Circadian Behavior Meiotic Spindle Organization Rhythmic Behavior Phosphatidylinositol Dephosphorylation Negative Regulation Of Cellular Senescence Postsynaptic Specialization Organization Dentate Gyrus Development Regulation Of Peptidyl-serine Phosphorylation System Development	Protein Binding
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