VAMP4 and PACS1

Number of citations of the paper that reports this interaction (PMID 14608369)
20

Data Source:
HPRD (in vivo, in vitro)

		VAMP4	PACS1
Gene Name		vesicle-associated membrane protein 4	phosphofurin acidic cluster sorting protein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Lysosome Endosome Golgi Apparatus Trans-Golgi Network Cell Surface Integral Component Of Membrane SNARE Complex	Cytosol COPI-coated Vesicle
	Molecular Function	SNARE Binding SNAP Receptor Activity	Protein Binding Ion Channel Binding
	Biological Process	Microtubule Cytoskeleton Organization Exocytosis ER To Golgi Vesicle-mediated Transport SNARE Complex Assembly Regulation Of Golgi To Plasma Membrane Protein Transport Golgi To Plasma Membrane Protein Transport Golgi Ribbon Formation	Protein Targeting To Golgi Viral Process Regulation Of Defense Response To Virus By Virus Protein Targeting To Plasma Membrane
Pathways			Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Nef mediated downregulation of MHC class I complex cell surface expression
Drugs
Diseases
GWAS			Bipolar disorder ( 21926972) Obesity (early onset extreme) ( 23563609)
Protein-Protein Interactions		9 interactors: AP1M1 BCL2L13 CCDC155 CSNK2A1 PACS1 SNAP29 STX16 STX4 STX6	10 interactors: CLCN7 CSNK2A1 FURIN GGA3 IGF2R JUN PKD2 PPP2CA PPP2CB VAMP4
Entrez ID		8674	55690
HPRD ID		06070	06320
Ensembl ID		ENSG00000117533	ENSG00000175115
Uniprot IDs		O75379 Q6IAZ3	Q6VY07
PDB IDs
Enriched GO Terms of Interacting Partners?		Vesicle Fusion Vesicle Organization Organelle Fusion Golgi Vesicle Transport Membrane Fusion Membrane Organization Establishment Of Localization In Cell Golgi Ribbon Formation Protein Transport Cellular Localization Vesicle-mediated Transport Establishment Of Protein Localization Synaptic Vesicle Fusion To Presynaptic Membrane Intracellular Protein Transport Protein Localization Regulation Of Defense Response To Virus By Virus Endosomal Transport Cellular Protein Localization Intracellular Transport Intra-Golgi Vesicle-mediated Transport Synaptic Vesicle Exocytosis Establishment Of Organelle Localization Retrograde Transport, Endosome To Golgi Organelle Organization Golgi Organization Chromosome Localization To Nuclear Envelope Involved In Synapsis Organelle Localization Vesicle Docking Regulation Of Defense Response To Virus Endomembrane System Organization Post-Golgi Vesicle-mediated Transport Membrane Docking Neurotransmitter Secretion Synaptic Vesicle Transport Positive Regulation Of Eosinophil Degranulation Regulation Of Neurotransmitter Levels Neurotransmitter Transport Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Establishment Of Vesicle Localization Regulation Of Cysteine-type Endopeptidase Activity Vesicle Localization Positive Regulation Of Protein Localization To Cell Surface Autophagic Vacuole Fusion Pigment Granule Maturation Endosome To Melanosome Transport Positive Regulation Of Immunoglobulin Secretion Synaptic Vesicle Priming Transport Cellular Pigment Accumulation SNARE Complex Assembly	Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Protein Catabolic Process Liver Development Cell Death Death Cell Surface Receptor Signaling Pathway Response To Reactive Oxygen Species Regulation Of Protein Autophosphorylation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Response To Organic Substance Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Endothelial Cell Proliferation Negative Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Apoptotic Mitochondrial Changes Phosphate-containing Compound Metabolic Process Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Metanephric Cortex Development Metanephric Cortical Collecting Duct Development Cellular Response To Potassium Ion Starvation Negative Regulation Of Cellular Protein Catabolic Process Apoptotic Process Cellular Response To Organic Substance Programmed Cell Death Regulation Of Endothelial Cell Proliferation Response To Oxidative Stress Regulation Of Signaling Regulation Of Cellular Protein Metabolic Process Establishment Of Localization In Cell Cellular Protein Modification Process Response To Inorganic Substance Protein Kinase D Signaling Leading Edge Cell Differentiation Nerve Growth Factor Production Metanephric Smooth Muscle Tissue Development Detection Of Nodal Flow Renal Artery Morphogenesis Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Gland Development Regulation Of Receptor Activity Positive Regulation Of Metabolic Process Negative Regulation Of Protein Catabolic Process Transport Response To Hydrogen Peroxide Negative Regulation Of Transforming Growth Factor Beta1 Production
Tagcloud ?		adm adriamycin arrb2 bigger cblb chip cryopreservation doubling effectors endoperoxide exocytosis exudation gliomas impulse ingestion mdr medip ontology pard6b pgp pkcalpha rh123 sgh snap47 tgfb1 vamp3 verify vps4b wizened	acidic adaptor adaptors amyloidogenic app breakdown breaks cathepsin cation cytosolic endosomes golgi hallmark impairs inability investigating mannose phosphofurin prevents proper repeats routing shuttles sorla sort sorting studying tgn unexplored
Tagcloud (Difference) ?		adm adriamycin arrb2 bigger cblb chip cryopreservation doubling effectors endoperoxide exocytosis exudation gliomas impulse ingestion mdr medip ontology pard6b pgp pkcalpha rh123 sgh snap47 tgfb1 vamp3 verify vps4b wizened	acidic adaptor adaptors amyloidogenic app breakdown breaks cathepsin cation cytosolic endosomes golgi hallmark impairs inability investigating mannose phosphofurin prevents proper repeats routing shuttles sorla sort sorting studying tgn unexplored
Tagcloud (Intersection) ?