VAMP4 and PTGES

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		VAMP4	PTGES
Description		vesicle associated membrane protein 4	prostaglandin E synthase
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosome Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Cell Surface Membrane Transport Vesicle Endocytic Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane SNARE Complex Trans-Golgi Network Membrane Phagocytic Vesicle Bounding Membrane Of Organelle Presynaptic Endosome Membrane Glutamatergic Synapse	Nuclear Envelope Lumen Cytoplasm Endoplasmic Reticulum Membrane Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Glutathione Transferase Activity Glutathione Peroxidase Activity Prostaglandin-D Synthase Activity Protein Binding Oxidoreductase Activity Transferase Activity Isomerase Activity Glutathione Binding Prostaglandin-E Synthase Activity
	Biological Process	Synaptic Vesicle To Endosome Fusion Vesicle-mediated Transport Endocytic Recycling SNARE Complex Assembly Regulation Of Golgi To Plasma Membrane Protein Transport Golgi To Plasma Membrane Protein Transport Cellular Response To Type II Interferon Golgi Ribbon Formation Vesicle-mediated Transport To The Plasma Membrane Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Vesicle-mediated Transport In Synapse Regulation Of Synaptic Vesicle Endocytosis	Prostaglandin Biosynthetic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Prostaglandin Metabolic Process Signal Transduction Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Sensory Perception Of Pain Regulation Of Fever Generation Positive Regulation Of Prostaglandin Secretion Regulation Of Inflammatory Response Cellular Oxidant Detoxification
Pathways		Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872) Hippocampal atrophy ( 25625606) Metabolite levels ( 23823483) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Asthma ( 27611488) Pars orbitalis volume ( 31530798) Type 1 diabetes (age at diagnosis) ( 33179336)
Interacting Genes		50 interacting genes: ANKS6 AP1M1 AQP6 ARL13B BCL2L13 BIK CD79A CFTR CISD2 CPLX4 CSNK2A1 CYB5R3 DNAJC5 EBP ELOVL4 ERGIC3 EVI2B FAM209A FAM210B GPR152 GPX8 HSD17B13 KASH5 LDLRAD1 LEUTX MFF MGST3 MTIF3 PACS1 PSCA PTGES REEP4 RETREG3 SAR1A SCN3B SEC11C SLC10A6 SLC35H1 SSMEM1 STOM STX16 STX1A STX4 STX6 SYT2 TM4SF19 TMEM205 TMEM51 TMX2 TRIM54	18 interacting genes: ARLN BET1 EHHADH GIMAP1 GIMAP5 PLP2 PTGER1 PTGER2 SEC22A SERP2 SMCO4 TMEM19 TMEM222 TMEM65 VAMP3 VAMP4 VAPB YIF1A
Entrez ID		8674	9536
HPRD ID		06070	05528
Ensembl ID		ENSG00000117533	ENSG00000148344
Uniprot IDs		O75379 Q6IAZ3	O14684
PDB IDs			3DWW 4AL0 4AL1 4BPM 4WAB 4YK5 4YL0 4YL1 4YL3 5BQG 5BQH 5BQI 5K0I 5T36 5T37 5TL9 6VL4 8PYV
Enriched GO Terms of Interacting Partners?		Membrane SNARE Binding SNARE Complex Vesicle Docking Endoplasmic Reticulum Membrane Organelle Localization By Membrane Tethering Endoplasmic Reticulum SNAP Receptor Activity Membrane Docking Glutathione Peroxidase Activity Synaptic Vesicle Membrane Protein Binding Steroid Biosynthetic Process Synaptic Vesicle Exocytosis Cholesterol Biosynthetic Process Chloride Channel Inhibitor Activity Unsaturated Fatty Acid Metabolic Process ATP-dependent Protein Binding Mitochondrial Membrane Vesicle Fusion Chromaffin Granule Membrane Sterol Biosynthetic Process Organelle Membrane Fusion Small Molecule Biosynthetic Process Vesicle Organization Mitochondrial Outer Membrane Syntaxin Binding Vesicle-mediated Transport SNARE Complex Assembly Organelle Fusion Intracellular Protein Transport Endomembrane System Membrane Fusion	Golgi Vesicle Transport Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum To Golgi Vesicle-mediated Transport SNAP Receptor Activity Prostaglandin E Receptor Activity SNARE Complex Endoplasmic Reticulum SNARE Complex Assembly Transport Vesicle Vesicle Organization Organelle Fusion Response To Prostaglandin E Membrane Fusion Golgi To Plasma Membrane Protein Transport Vesicle-mediated Transport Intracellular Transport Establishment Of Protein Localization To Plasma Membrane Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Intramolecular Oxidoreductase Activity, Transposing C=C Bonds Presynaptic Endosome Membrane Golgi To Plasma Membrane Transport Negative Regulation By Virus Of Viral Protein Levels In Host Cell Endoplasmic Reticulum Unfolded Protein Response Clathrin-coated Endocytic Vesicle Membrane Cellular Response To Type II Interferon Synaptic Vesicle To Endosome Fusion FFAT Motif Binding Organelle Localization By Membrane Tethering Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Delta(3)-delta(2)-enoyl-CoA Isomerase Activity Prostaglandin Receptor Activity Cellular Localization Protein Transport Golgi Membrane Phagocytic Vesicle Establishment Of Localization In Cell Membrane Organization Response To Unfolded Protein Membrane Docking Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Response To Type II Interferon Post-Golgi Vesicle-mediated Transport COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Organelle Membrane Fusion Vesicle Fusion (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Trans-Golgi Network Membrane Host-mediated Perturbation Of Viral RNA Genome Replication
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