APOBEC3A and HAGH

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		APOBEC3A	HAGH
Name		apolipoprotein B mRNA editing enzyme catalytic subunit 3A	hydroxyacylglutathione hydrolase
Structure
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	RNA Binding Catalytic Activity Cytidine Deaminase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Hydroxyacylglutathione Hydrolase Activity Protein Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Immune System Process Transposable Element Silencing Cytidine To Uridine Editing Positive Regulation Of Gene Expression Via Chromosomal CpG Island Demethylation Clearance Of Foreign Intracellular DNA Negative Regulation Of Viral Genome Replication Innate Immune Response Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Defense Response To Virus DNA Cytosine Deamination	Glutathione Metabolic Process Glutathione Biosynthetic Process Methylglyoxal Catabolic Process To D-lactate Via S-lactoyl-glutathione
Pathways		mRNA Editing: C to U Conversion Formation of the Editosome	None
Drugs		None	Glutathione S-(N-hydroxy-N-bromophenylcarbamoyl)glutathione
GWAS		Bladder cancer ( 20972438 24163127 ) Breast cancer ( 29059683 ) Red cell distribution width ( 32888494 )	No GWAS studies recorded
Novel Interactors		None recorded	1 novel interactors: TIMM10
Interacting Genes		3 interacting genes: HAGH STAMBP TRIB3	6 interacting genes: APOBEC3A APP BST2 MYOC SHANK3 TERF2IP
Entrez ID		200315	3029
HPRD ID		06168	00731
Ensembl ID		ENSG00000128383	ENSG00000063854
Uniprot IDs		A0A0K0MJ49 B7ZLZ1 P31941	H3BPQ4 Q16775
PDB IDs		2M65 4XXO 5KEG 5SWW 7D3V 7D3W 7D3X 8FII 8FIJ 8FIK 8FIL 8FIM	1QH3 1QH5
GO Terms Enriched among Interactors		Hydroxyacylglutathione Hydrolase Activity Methylglyoxal Catabolic Process To Lactate Cellular Detoxification Of Methylglyoxal Methylglyoxal Catabolic Process To D-lactate Via S-lactoyl-glutathione Regulation Of Hippocampal Neuron Apoptotic Process Negative Regulation Of Hippocampal Neuron Apoptotic Process Hippocampal Neuron Apoptotic Process Ubiquitin-protein Transferase Regulator Activity Methylglyoxal Metabolic Process Lactate Metabolic Process Glutathione Biosynthetic Process Aldehyde Catabolic Process Ketone Catabolic Process Cellular Detoxification Of Aldehyde K63-linked Deubiquitinase Activity Metal-dependent Deubiquitinase Activity Mitogen-activated Protein Kinase Kinase Binding Ubiquitin Ligase Activator Activity Negative Regulation Of Fatty Acid Biosynthetic Process Peptide Biosynthetic Process Protein K63-linked Deubiquitination Deubiquitinase Activity Negative Regulation Of Ras Protein Signal Transduction Protein Serine/threonine Kinase Inhibitor Activity	Positive Regulation Of Gene Expression, Epigenetic Amyloid-beta Complex Regulation Of Neuronal Synaptic Plasticity Growth Cone Lamellipodium Neuron Projection Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Response To Calcium Ion Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Cell Communication Amylin Binding Positive Regulation Of Signaling Regulation Of Supramolecular Fiber Organization Positive Regulation Of Toll Signaling Pathway Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Frizzled Binding Modulation Of Excitatory Postsynaptic Potential Regulation Of Viral Genome Replication Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Negative Regulation Of Viral Process Negative Regulation Of Viral Genome Replication Negative Regulation Of Plasmacytoid Dendritic Cell Cytokine Production Negative Regulation Of Actin Filament Bundle Assembly Skeletal Muscle Hypertrophy Mitochondrial Intermembrane Space Acetylcholine Receptor Activator Activity Protein-folding Chaperone Binding Positive Regulation Of Cellular Component Organization Associative Learning Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Membrane Potential Positive Regulation Of JNK Cascade Neuron Projection Development Positive Regulation Of Intracellular Signal Transduction Lipoprotein Particle Mitochondrial Inner Membrane Positive Regulation Of Protein Import Negative Regulation Of Intracellular Transport Of Viral Material Negative Regulation Of Dendritic Cell Cytokine Production Regulation Of Organelle Organization Negative Regulation Of DNA Recombination At Telomere Guanylate Kinase-associated Protein Clustering Regulation Of Viral Life Cycle Regulation Of Cellular Component Organization PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import