APOBEC3A

Description		apolipoprotein B mRNA editing enzyme catalytic subunit 3A
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GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Binding Catalytic Activity Cytidine Deaminase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Immune System Process Transposable Element Silencing Cytidine To Uridine Editing Positive Regulation Of Gene Expression Via Chromosomal CpG Island Demethylation Clearance Of Foreign Intracellular DNA Negative Regulation Of Viral Genome Replication Innate Immune Response Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Defense Response To Virus DNA Cytosine Deamination
Pathways		mRNA Editing: C to U Conversion Formation of the Editosome
Drugs
Diseases
GWAS		Bladder cancer ( 20972438 24163127) Breast cancer ( 29059683) Red cell distribution width ( 32888494)
Interacting Genes		3 interacting genes: HAGH STAMBP TRIB3
Entrez ID		200315
HPRD ID		06168
Ensembl ID		ENSG00000128383
Uniprot IDs		A0A0K0MJ49 B7ZLZ1 P31941
PDB IDs		2M65 4XXO 5KEG 5SWW 7D3V 7D3W 7D3X 8FII 8FIJ 8FIK 8FIL 8FIM
Enriched GO Terms of Interacting Partners?		Hydroxyacylglutathione Hydrolase Activity Methylglyoxal Catabolic Process To Lactate Cellular Detoxification Of Methylglyoxal Methylglyoxal Catabolic Process To D-lactate Via S-lactoyl-glutathione Regulation Of Hippocampal Neuron Apoptotic Process Negative Regulation Of Hippocampal Neuron Apoptotic Process Hippocampal Neuron Apoptotic Process Ubiquitin-protein Transferase Regulator Activity Methylglyoxal Metabolic Process Lactate Metabolic Process Glutathione Biosynthetic Process Aldehyde Catabolic Process Ketone Catabolic Process Cellular Detoxification Of Aldehyde K63-linked Deubiquitinase Activity Metal-dependent Deubiquitinase Activity Mitogen-activated Protein Kinase Kinase Binding Ubiquitin Ligase Activator Activity Negative Regulation Of Fatty Acid Biosynthetic Process Peptide Biosynthetic Process Protein K63-linked Deubiquitination Deubiquitinase Activity Negative Regulation Of Ras Protein Signal Transduction Protein Serine/threonine Kinase Inhibitor Activity
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