CYB561A3 and CLDN7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CYB561A3	CLDN7
Description		cytochrome b561 family member A3	claudin 7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleolus Lysosome Lysosomal Membrane Endosome Membrane Late Endosome Membrane	Plasma Membrane Bicellular Tight Junction Membrane Basolateral Plasma Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane Anchoring Junction
	Molecular Function	Protein Binding Oxidoreductase Activity Metal Ion Binding Transmembrane Ascorbate Ferrireductase Activity	Structural Molecule Activity Protein Binding Identical Protein Binding
	Biological Process	Intracellular Iron Ion Homeostasis Transmembrane Transport	Cell Adhesion Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Bicellular Tight Junction Assembly
Pathways			Tight junction interactions
Drugs
Diseases
GWAS			Birth weight ( 27680694 31043758) FEV1 ( 30804560) Lung function (FVC) ( 30804560) Multiple sclerosis ( 31604244) Offspring birth weight ( 31043758)
Interacting Genes		23 interacting genes: AGPAT5 AOC1 AQP6 CD40 CD79A CLDN5 CLDN7 CREB3L3 EHHADH FFAR2 GPR101 GPR152 GPR37L1 GPX8 HERPUD2 KLRC1 LAPTM4B PVR RNF185 RNF5 SHISAL1 TM4SF18 TMEM31	77 interacting genes: AIG1 ANKRD46 APOD AQP2 ASGR1 BCL2L2 BET1 BMP10 C3orf52 CD53 CD72 CLN6 CMTM5 CNIH1 COL4A5 CXCL16 CXCL9 CYB561A3 CYB561D2 CYB5B CYBC1 EDDM3B EMP3 EPCAM ERG28 ERMP1 FAXDC2 FXYD6 GIMAP5 GLP1R GPR37L1 HGD IGFBP5 ITM2A JAGN1 LAT LEPROTL1 LPAR3 LSMEM2 MAL MALL MS4A13 NDUFB11 NIPAL4 NKG7 OLFM4 PGAP2 PLN RHOXF2 RPRM RTP2 SCAMP4 SCARF1 SEC22B SERTM1 SLC38A7 SLC61A1 SYNE4 TJP1 TMEM100 TMEM11 TMEM128 TMEM140 TMEM147 TMEM44 TMEM60 TMEM97 TNF TRARG1 TSPAN33 UBIAD1 UNC93B1 UPK1B UPK2 VAMP3 VAMP5 VSTM1
Entrez ID		220002	1366
HPRD ID		11316	07633
Ensembl ID		ENSG00000162144	ENSG00000181885
Uniprot IDs		F5H1Q2 Q8NBI2	A0A384ME58 F5H496 O95471
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Ubiquitin-like Protein Conjugating Enzyme Binding Positive Regulation Of Immune Response Positive Regulation Of Immune Effector Process Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Apicolateral Plasma Membrane Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Defense Response Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Protein Alpha-1,2-demannosylation Response To Endoplasmic Reticulum Stress Endoplasmic Reticulum Mannose Trimming Endoplasmic Reticulum Quality Control Compartment Protein Deglycosylation Bicellular Tight Junction Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Diamine Oxidase Activity Putrescine Oxidase Activity Histamine Oxidase Activity Nitrate Transmembrane Transporter Activity Regulation Of Immune Response Immune Response-activating Signaling Pathway Positive Regulation Of Natural Killer Cell Mediated Immunity Inhibitory MHC Class Ib Receptor Activity B Cell Proliferation G Protein-coupled Receptor Activity Plasma Membrane PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Positive Regulation Of Immune System Process Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Lymphocyte Mediated Immunity Activation Of Immune Response Bicellular Tight Junction Assembly Tight Junction Organization Tight Junction Assembly Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Intramolecular Oxidoreductase Activity, Transposing C=C Bonds Innate Immune Response-activating Signaling Pathway Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Regulation Of Innate Immune Response Activation Of Innate Immune Response Regulation Of Acute Inflammatory Response HLA-E Specific Inhibitory MHC Class Ib Receptor Activity Receptor Complex Regulation Of T Cell Mediated Cytotoxicity	Membrane Protein Binding Endoplasmic Reticulum Membrane Endoplasmic Reticulum Plasma Membrane Localization Within Membrane Transmembrane Ascorbate Ferrireductase Activity
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