EEF1A2 and CHRM4

Number of citations of the paper that reports this interaction (PMID 12048193)
4

Data Source:
HPRD (in vivo, in vitro)

		EEF1A2	CHRM4
Gene Name		eukaryotic translation elongation factor 1 alpha 2	cholinergic receptor, muscarinic 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Eukaryotic Translation Elongation Factor 1 Complex Neuronal Cell Body	Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Postsynaptic Membrane
	Molecular Function	Translation Elongation Factor Activity GTPase Activity GTP Binding Translation Factor Activity, Nucleic Acid Binding	G-protein Coupled Acetylcholine Receptor Activity
	Biological Process	Translational Elongation Response To Inorganic Substance Positive Regulation Of Apoptotic Process	Signal Transduction Cell Surface Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Acetylcholine Receptor Signaling Pathway G-protein Coupled Acetylcholine Receptor Signaling Pathway Cell Proliferation Regulation Of Locomotion
Pathways		Translation Eukaryotic Translation Elongation	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) Muscarinic acetylcholine receptors Amine ligand-binding receptors G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Ziprasidone Amitriptyline Olanzapine Metixene Clozapine Trihexyphenidyl Procyclidine Promazine Hyoscyamine Imipramine Darifenacin Nortriptyline Atropine Nicardipine Paroxetine Homatropine Methylbromide Scopolamine Benzquinamide Propiomazine Cryptenamine Tropicamide Brompheniramine Maprotiline Tolterodine Promethazine Doxepin Desipramine Quetiapine Aripiprazole Chlorprothixene Methotrimeprazine Solifenacin Isopropamide Fesoterodine Aclidinium
Diseases
GWAS		Prostate cancer ( 23535732)
Protein-Protein Interactions		5 interactors: ABTB1 CHRM4 ERG MAPK6 TSPY1	3 interactors: EEF1A2 GPRASP1 GRB2
Entrez ID		1917	1132
HPRD ID		04265	00330
Ensembl ID		ENSG00000101210	ENSG00000180720
Uniprot IDs		Q05639	P08173
PDB IDs		3C5J
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Potassium Ion Export Cell Proliferation Regulation Of Heart Rate By Hormone Adenylate Cyclase-inhibiting G-protein Coupled Acetylcholine Receptor Signaling Pathway Signal Transduction By Phosphorylation Gonadal Mesoderm Development Regulation Of Heart Rate By Chemical Signal Peptidyl-histidine Phosphorylation Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Potassium Ion Export Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Membrane Repolarization Negative Regulation Of Potassium Ion Transmembrane Transport G-protein Coupled Acetylcholine Receptor Signaling Pathway Potassium Ion Homeostasis Phosphorelay Signal Transduction System Positive Regulation Of Potassium Ion Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Potassium Ion Transport Regulation Of Membrane Repolarization Regulation Of Heart Rate By Cardiac Conduction Synaptic Transmission Cardiac Muscle Cell Action Potential Involved In Contraction Positive Regulation Of Potassium Ion Transport Membrane Depolarization During Action Potential Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport	Receptor Metabolic Process G-protein Coupled Receptor Catabolic Process
Tagcloud ?		2a akt axis cascade chimeric corroborated de elongation eukaryotic hcc hepatocellular homolog lowered mdm4 mechanistic minute mtor oncogene phosphoinositide pi3k protease proteasomal rapamycin strong subset thymoma ubiquitination upregulation
Tagcloud (Difference) ?		2a akt axis cascade chimeric corroborated de elongation eukaryotic hcc hepatocellular homolog lowered mdm4 mechanistic minute mtor oncogene phosphoinositide pi3k protease proteasomal rapamycin strong subset thymoma ubiquitination upregulation
Tagcloud (Intersection) ?