EEF1A2 and TTLL12

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		EEF1A2	TTLL12
Description		eukaryotic translation elongation factor 1 alpha 2	tubulin tyrosine ligase like 12
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Eukaryotic Translation Elongation Factor 1 Complex Membrane Synapse Cytoplasmic Side Of Lysosomal Membrane	Nucleus Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Plasma Membrane Midbody
	Molecular Function	Nucleotide Binding Translation Elongation Factor Activity GTPase Activity Protein Binding GTP Binding Translation Factor Activity, RNA Binding Hydrolase Activity Protein Kinase Binding Metal Ion Binding	Nucleotide Binding Tubulin-tyrosine Ligase Activity Protein Binding ATP Binding Histone H4K20me2 Reader Activity Histone H4K20 Trimethyltransferase Activity
	Biological Process	Translation Translational Elongation Positive Regulation Of Apoptotic Process Positive Regulation Of Lipid Kinase Activity Regulation Of Chaperone-mediated Autophagy	Immune System Process Chromatin Organization Regulation Of Mitotic Cell Cycle Innate Immune Response Negative Regulation Of Type I Interferon-mediated Signaling Pathway
Pathways		Eukaryotic Translation Elongation	Carboxyterminal post-translational modifications of tubulin
Drugs		Plitidepsin
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Prostate cancer ( 23535732) Serum metabolite levels ( 33031748)	Molar-incisor hypomineralization ( 23918034) Monocyte count ( 27863252 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		12 interacting genes: CHRM4 ERG HUNK LINC00941 MAPK6 PKNOX1 SMN1 STK11 SUMO2 TSPY1 TTLL12 UBE3A	10 interacting genes: CEBPA CSNK2A2 DNAJB1 EEF1A1 EEF1A2 FAM222B FILNC1 LCOR PRR35 SUMO2
Entrez ID		1917	23170
HPRD ID		04265	13782
Ensembl ID		ENSG00000101210	ENSG00000100304
Uniprot IDs		Q05639	Q14166
PDB IDs		3C5J 8B6Z
Enriched GO Terms of Interacting Partners?			Regulation Of Protein Catabolic Process Eukaryotic Translation Elongation Factor 1 Complex Regulation Of Chaperone-mediated Autophagy Cytoplasmic Side Of Lysosomal Membrane Translation Elongation Factor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Animal Organ Regeneration RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Translational Elongation Positive Regulation Of Lipid Kinase Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Response To Vitamin B2 C/EBP Complex Regulation Of Protein Metabolic Process Regulation Of Autophagy Kinase Binding CHOP-C/EBP Complex Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Liver Development Protein Kinase CK2 Complex Positive Regulation Of Protein Folding Positive Regulation Of Proteasomal Protein Catabolic Process White Fat Cell Proliferation Regulation Of Lipid Kinase Activity Histone Deacetylase Binding Regeneration Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex
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