KCNJ9 and ATP6V1A

		KCNJ9	ATP6V1A
Description		potassium inwardly rectifying channel subfamily J member 9	ATPase H+ transporting V1 subunit A
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GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Monoatomic Ion Channel Complex Presynaptic Membrane Parallel Fiber To Purkinje Cell Synapse Inward Rectifier Potassium Channel Complex	Golgi Membrane Vacuolar Proton-transporting V-type ATPase, V1 Domain Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Plasma Membrane Microvillus Endosome Membrane Membrane Apical Plasma Membrane Proton-transporting Two-sector ATPase Complex Transport Vesicle Secretory Granule Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Proton-transporting V-type ATPase Complex Proton-transporting V-type ATPase, V1 Domain Extracellular Exosome Extrinsic Component Of Synaptic Vesicle Membrane ATPase Complex
	Molecular Function	Inward Rectifier Potassium Channel Activity Protein Binding G-protein Activated Inward Rectifier Potassium Channel Activity Ligand-gated Monoatomic Cation Channel Activity	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Proton-transporting ATPase Activity, Rotational Mechanism
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Presynaptic Membrane Potential Potassium Ion Import Across Plasma Membrane	Monoatomic Ion Transport Intracellular Iron Ion Homeostasis Vacuolar Acidification Lysosomal Lumen Acidification Regulation Of Macroautophagy Cellular Response To Increased Oxygen Levels Homeostatic Process ATP Metabolic Process Endosomal Lumen Acidification Intracellular PH Reduction Golgi Lumen Acidification Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport
Pathways		Activation of G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
Drugs		Ethanol Isavuconazole	Alendronic acid Etidronic acid Tiludronic acid Bafilomycin A1 Bafilomycin B1
Diseases
GWAS		Alcohol consumption over the past year ( 29058377)	Prostate cancer ( 23535732)
Interacting Genes		6 interacting genes: ADRB2 DRD2 DRD4 KCNJ3 KCNJ6 TMEM201	7 interacting genes: ANXA7 CDC42 CDKN1A SMN1 TK1 TUFM UBC
Entrez ID		3765	523
HPRD ID		02959	06120
Ensembl ID		ENSG00000162728	ENSG00000114573
Uniprot IDs		Q92806	P38606
PDB IDs		6X23	6WLZ 6WM2 6WM3 6WM4 7U4T 7UNF
Enriched GO Terms of Interacting Partners?		Potassium Channel Regulator Activity Norepinephrine Binding Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission G-protein Activated Inward Rectifier Potassium Channel Activity Dopamine Neurotransmitter Receptor Activity Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Dopamine Binding Positive Regulation Of Neurotransmitter Uptake Regulation Of Dopamine Uptake Involved In Synaptic Transmission Phospholipase C-activating Dopamine Receptor Signaling Pathway Behavioral Response To Ethanol Response To Histamine Regulation Of Monoatomic Ion Transport Regulation Of Membrane Potential Synaptic Transmission, Dopaminergic Behavioral Response To Cocaine Regulation Of Neurotransmitter Uptake Arachidonate Secretion G Protein-coupled Dopamine Receptor Signaling Pathway Inward Rectifier Potassium Channel Activity Import Into Cell Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Response To Amphetamine Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Inorganic Ion Transmembrane Transport Temperature Homeostasis Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Regulation Of Transport Potassium Ion Import Across Plasma Membrane Response To Amine Negative Regulation Of Blood Pressure Long-chain Fatty Acid Transport Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Smooth Muscle Contraction Monoatomic Ion Transport Regulation Of Multicellular Organism Growth G Protein-coupled Receptor Activity Regulation Of Sodium Ion Transport Negative Regulation Of Protein Secretion Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Regulation Of Receptor Internalization Intracellular Monoatomic Cation Homeostasis Regulation Of Amine Transport Voltage-gated Potassium Channel Complex Intracellular Monoatomic Ion Homeostasis Inorganic Ion Homeostasis
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