DPH2 and IL17A

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		DPH2	IL17A
Name		diphthamide biosynthesis 2	interleukin 17A
Structure		No pdb structure
GO Annotations	Cellular Component	Cytosol Protein-containing Complex 2-(3-amino-3-carboxypropyl)histidine Synthase Complex	Extracellular Region Extracellular Space External Side Of Plasma Membrane
	Molecular Function	Protein Binding Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding 2-(3-amino-3-carboxypropyl)histidine Synthase Activity	Cytokine Activity Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Protein Histidyl Modification To Diphthamide	Positive Regulation Of Antimicrobial Peptide Production Adaptive Immune Response Immune System Process Apoptotic Process Inflammatory Response Immune Response Notch Signaling Pathway Cell-cell Signaling Cell Death Response To Wounding Gene Expression Positive Regulation Of Keratinocyte Proliferation Keratinocyte Differentiation Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-16 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Interleukin-17A-mediated Signaling Pathway Keratinocyte Proliferation Innate Immune Response Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Intestinal Epithelial Structure Maintenance Cellular Response To Interleukin-1 Fibroblast Activation Regulation Of Primary Metabolic Process Interleukin-17-mediated Signaling Pathway Granulocyte Migration Negative Regulation Of Inflammatory Response To Wounding Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Bicellular Tight Junction Assembly Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Negative Regulation Of Interleukin-17-mediated Signaling Pathway Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production
Pathways		Synthesis of diphthamide-EEF2	Interleukin-17 signaling Interleukin-4 and Interleukin-13 signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs		None	Secukinumab Ixekizumab Bimekizumab
GWAS		Autism spectrum disorder or schizophrenia ( 28540026 )	Height ( 28552196 )
Novel Interactors		1 novel interactors: BEST4	None recorded
Interacting Genes		7 interacting genes: CRYGA FARS2 IL17A MAGOH MISP NEK6 TNK2	3 interacting genes: DPH2 IL17RA KCNIP4
Entrez ID		1802	3605
HPRD ID		16023	04396
Ensembl ID		ENSG00000132768	ENSG00000112115
Uniprot IDs		B3KRB8 Q9BQC3	Q16552
PDB IDs		Not available	2VXS 4HR9 4HSA 4QHU 5HHV 5HHX 5HI3 5HI4 5HI5 5N7W 5N92 5NAN 5VB9 6WIO 6WIR 7AMA 7AMG 7UWM 7UWN 7WKX 7Z2M 7ZAN 8B7W 8CDG 8DY1 8DY5 8DYF 8DYG 8DYH 8DYI 8USR 8USS 9FKX 9FL3 9H4D 9H4O
GO Terms Enriched among Interactors		None	2-(3-amino-3-carboxypropyl)histidine Synthase Complex Protein Histidyl Modification To Diphthamide 2-(3-amino-3-carboxypropyl)histidine Synthase Activity Fibroblast Activation Positive Regulation Of Interleukin-23 Production Interleukin-17 Receptor Activity T-helper 17 Type Immune Response Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Interleukin-17A-mediated Signaling Pathway Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Regulation Of Interleukin-23 Production Interleukin-17-mediated Signaling Pathway Positive Regulation Of Interleukin-5 Production Positive Regulation Of Interleukin-13 Production Regulation Of Interleukin-5 Production Positive Regulation Of Cytokine Production Involved In Inflammatory Response