DPH2 and CRYGA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DPH2	CRYGA
Description		diphthamide biosynthesis 2	crystallin gamma A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Protein-containing Complex 2-(3-amino-3-carboxypropyl)histidine Synthase Complex
	Molecular Function	Protein Binding Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding 2-(3-amino-3-carboxypropyl)histidine Synthase Activity	Structural Constituent Of Eye Lens
	Biological Process	Protein Histidyl Modification To Diphthamide	Eye Development Lens Development In Camera-type Eye Visual Perception
Pathways		Synthesis of diphthamide-EEF2
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026)
Interacting Genes		7 interacting genes: CRYGA FARS2 IL17A MAGOH MISP NEK6 TNK2	5 interacting genes: AGR2 DPH2 HSPA13 PSMB9 TRAF1
Entrez ID		1802	1418
HPRD ID		16023	00433
Ensembl ID		ENSG00000132768	ENSG00000168582
Uniprot IDs		B3KRB8 Q9BQC3	A0A0S2A4T3 P11844
PDB IDs
Enriched GO Terms of Interacting Partners?			2-(3-amino-3-carboxypropyl)histidine Synthase Complex Protein Histidyl Modification To Diphthamide 2-(3-amino-3-carboxypropyl)histidine Synthase Activity Threonine-type Endopeptidase Activity Spermatoproteasome Complex Proteasome Core Complex, Beta-subunit Complex Thioesterase Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Muscle Atrophy Ripoptosome Positive Regulation Of Cell Proliferation Involved In Kidney Development Negative Regulation Of Hepatocyte Apoptotic Process Skeletal Myofibril Assembly Negative Regulation Of Myoblast Fusion Negative Regulation Of Syncytium Formation By Plasma Membrane Fusion Death-inducing Signaling Complex Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Skeletal Muscle Atrophy CD95 Death-inducing Signaling Complex Skeletal Muscle Adaptation Regulation Of Glomerular Mesangial Cell Proliferation Striated Muscle Atrophy Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Glomerular Mesangial Cell Proliferation Lung Goblet Cell Differentiation Dystroglycan Binding Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Skeletal Muscle Cell Proliferation Cellular Response To Nitric Oxide Death Receptor Binding Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Hepatocyte Proliferation Regulation Of Skeletal Muscle Satellite Cell Proliferation Cellular Response To Reactive Nitrogen Species Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of IRE1-mediated Unfolded Protein Response Regulation Of PERK-mediated Unfolded Protein Response Mucus Secretion
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