DPH2 and BEST4

		DPH2	BEST4
Description		diphthamide biosynthesis 2	bestrophin 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Protein-containing Complex 2-(3-amino-3-carboxypropyl)histidine Synthase Complex	Plasma Membrane Membrane Chloride Channel Complex
	Molecular Function	Protein Binding Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding 2-(3-amino-3-carboxypropyl)histidine Synthase Activity	Intracellularly Calcium-gated Chloride Channel Activity Chloride Channel Activity Channel Activity Metal Ion Binding Bicarbonate Channel Activity
	Biological Process	Protein Histidyl Modification To Diphthamide	Monoatomic Ion Transport Chloride Transport Bicarbonate Transport Monoatomic Ion Transmembrane Transport Chloride Transmembrane Transport
Pathways		Synthesis of diphthamide-EEF2	Stimuli-sensing channels
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026)
Interacting Genes		7 interacting genes: CRYGA FARS2 IL17A MAGOH MISP NEK6 TNK2
Entrez ID		1802	266675
HPRD ID		16023	09549
Ensembl ID		ENSG00000132768	ENSG00000142959
Uniprot IDs		B3KRB8 Q9BQC3	Q8NFU0
PDB IDs
Enriched GO Terms of Interacting Partners?			2-(3-amino-3-carboxypropyl)histidine Synthase Complex 2-(3-amino-3-carboxypropyl)histidine Synthase Activity Protein Histidyl Modification To Diphthamide 4 Iron, 4 Sulfur Cluster Binding Iron-sulfur Cluster Binding
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