AGL and NHLRC1

Number of citations of the paper that reports this interaction (PubMedID 17908927)
36

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		AGL	NHLRC1
Description		amylo-alpha-1,6-glucosidase and 4-alpha-glucanotransferase	NHL repeat containing E3 ubiquitin protein ligase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Inclusion Body Sarcoplasmic Reticulum Secretory Granule Lumen Isoamylase Complex Ficolin-1-rich Granule Lumen	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Catalytic Activity 4-alpha-glucanotransferase Activity Amylo-alpha-1,6-glucosidase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Carbohydrate Binding Polysaccharide Binding Polyubiquitin Modification-dependent Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Carbohydrate Metabolic Process Glycogen Metabolic Process Glycogen Biosynthetic Process Glycogen Catabolic Process Response To Nutrient Response To Hormone Response To Glucocorticoid	Protein Polyubiquitination Glycogen Metabolic Process Glycogen Biosynthetic Process Autophagy Regulation Of Gene Expression Protein Ubiquitination Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Response To Endoplasmic Reticulum Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization To Plasma Membrane
Pathways		Neutrophil degranulation Glycogen breakdown (glycogenolysis)	Glycogen synthesis Myoclonic epilepsy of Lafora
Drugs
Diseases		Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)	Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Carotid intima media thickness ( 26343869) Incident chronic kidney disease ( 30955190) White matter integrity (bipolar disorder risk interaction) ( 23218918)	Intrinsic epigenetic age acceleration ( 29374233)
Interacting Genes		3 interacting genes: APPL1 NHLRC1 PRKAB1	8 interacting genes: AGL GYS1 NNAT PPP1R3C UBE2D1 UBE2D3 UBE2E1 UBE2H
Entrez ID		178	378884
HPRD ID		01984	06995
Ensembl ID		ENSG00000162688	ENSG00000187566
Uniprot IDs		A0A0S2A4E4 P35573	Q6VVB1
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Localization To Cell Periphery Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Macropinocytosis Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Protein Localization To Membrane Macropinosome Nucleotide-activated Protein Kinase Complex Nail Development Response To Hepatocyte Growth Factor Regulation Of Melanin Biosynthetic Process Positive Regulation Of Pinocytosis Early Phagosome Regulation Of Cellular Localization Positive Regulation Of Melanin Biosynthetic Process Cellular Response To Hepatocyte Growth Factor Stimulus Protein Kinase B Binding Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Adiponectin-activated Signaling Pathway Glycogen Biosynthetic Process Intracellular Vesicle Negative Regulation Of Phagocytosis Polysaccharide Biosynthetic Process Maintenance Of Synapse Structure Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of D-glucose Import Vesicle Membrane	Ubiquitin Conjugating Enzyme Activity Glycogen Biosynthetic Process Polysaccharide Biosynthetic Process Protein K48-linked Ubiquitination Glycogen Metabolic Process Ubiquitin-protein Transferase Activity Energy Reserve Metabolic Process Polysaccharide Metabolic Process Protein Polyubiquitination Carbohydrate Biosynthetic Process Transferase Activity Inclusion Body Macromolecule Catabolic Process Macromolecule Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein K11-linked Ubiquitination Protein Modification By Small Protein Conjugation Protein Monoubiquitination Generation Of Precursor Metabolites And Energy Protein Modification Process Post-translational Protein Modification Negative Regulation Of BMP Signaling Pathway Isoamylase Complex 4-alpha-glucanotransferase Activity Amylo-alpha-1,6-glucosidase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Carbohydrate Metabolic Process Catabolic Process Glycogen Synthase Activity, Transferring Glucose-1-phosphate Proteasomal Protein Catabolic Process Regulation Of BMP Signaling Pathway Proteolysis Alpha-1,4-glucan Glucosyltransferase (UDP-glucose Donor) Activity Negative Regulation Of Cellular Response To Growth Factor Stimulus Cytosol Protein Lipoylation ISG15 Transferase Activity Protein Catabolic Process ATP Binding Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway ISG15-protein Conjugation Glycosyltransferase Activity Glycogen Binding D-glucose Binding Protein Metabolic Process Nucleotide Binding
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